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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 3 | Full survival of paraquat-exposed rats after treatment with sodium salicylate显示文摘 | R.J. Dinis-Oliveira C. Sousa F. Remi?o J.A. Duarte A. Sánchez Navarro M.L. Bastos F. Carvalho | 2007 | Free Radical Biology and Medicine2007，，7： | 2 |
| 4 | A distribu- ted concurrency control mechanism for XML data 显示文摘 | Moreura L O SOUSA F R C MACHADO J C | 2011 | Journal of Compute and System Science2011，38，9： | 1 |
| 5 | Corticosteroid receptors and neuroplasticity显示文摘 | Sousa N Cerqueira J J Almeida O F X | 2008 | Brain Research Reciews2008，57，2： | 1 |
| 6 | Smooth muscle alpha actin expression and myofibroblast differentiation by TGF beta are dependent upon MK2显示文摘 | Sousa AM Lin T Guevara O | 2007 | J Cell Biochem2007，100，6： | 1 |
| 7 | Raman spectroscopic investigation of maghemite ferrofluids modified by the adsorption of zinc tetrasulfonated phthalocyanine显示文摘 | Jean C O Silva Marcelo H Sousa Francisco A Tourinho | 2002 | Langmuir2002，18，14： | 1 |
| 8 | Motion of the shoulder complex in individuals with isolated acromioelavieular osteoarthritis and associated with rotator cuff dysfunction: part 2-muscle activity显示文摘 | Sousa Cde O Michener LA Ribeiro IL | 2015 | J Sports Med2015，25，1： | 1 |
| 9 | Acetylcysteine for the prevention of renal outcomes in patients with diabetes mellitus undergoing coronary and peripheral vascular angiography: a sub- study of the acetylcysteine for contrast-induced nephropathy trial显示文摘 | Berwanger O Cavalcanti AB Sousa AM | 2013 | Cire Cardiovasc Interv2013，6，2： | 1 |
| 10 | The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production显示文摘 | Fabiola C. Nunes Jacqueline A. Leite Louise H. G. Oliveira Patrícia A. P. S. Sousa Márcio C. Menezes Jo?o P. S. Moraes Sandra R. Mascarenhas Valdir A. Braga | 2015 | Parasitology Research2015，，2： | 1 |
| 11 | Phenolic profile of Douro wines and evaluation of their NO scavenging capacity in LPS-stimulated RAW 264.7 macrophages显示文摘 | Manuel J. Rebelo Carla Sousa Patrícia Valent?o Rosa Rego Paula B. Andrade | 2014 | Food Chemistry2014，，： | 1 |
| 12 | Determining the Stress-crack Opening Curve of Concrete by Inverse Analysis显示文摘 | Sousa J L A O Gettu R | 2006 | Journal of Engineering Mechanics2006，132，2： | 1 |
| 13 | Generalization to square lattice of Sznajd sociophysics model显示文摘 | STAUFFER D SOUSA A O de OLIVERIRA S M | 2000 | International Journal of Modern Physics C2000，11，6： | 1 |
| 14 | Massively LDPC de- coding on muhicore architectures 显示文摘 | Gabriel Falc~o Leonel Sousa Vitor Silva | 2011 | IEEE Transactions on Parallel and Distributed Systems2011，22，2： | 1 |
| 15 | Activation of mouse oocytes requires multiple sperm factors but not sperm PLCgammal 显示文摘 | Heyers S Sousa M Cangir O | 2000 | Mol Cell Endocrinol2000，166，1： | 1 |
| 16 | Carbapenem-hydmlysing beta-lactamase from clinical isolates of Pseudomonas aeruginose in Portugal显示文摘 | Cardoso O Sousa JC Leitao R | 1999 | J Antimicrob Chemother1999，44，1： | 1 |
| 17 | Generalization to square lattice of SZNAJD sociophysics model显示文摘 | Stauffer D Sousa A O de Oliveira S M | 2000 | Internation- al Journal of Modem Physics C2000，11，6： | 1 |
| 18 | Industrial application of AISI 4340 steels treated in cathodic cage plasma nitriding technique显示文摘 | RIBEIRO K J B de SOUSA R R M de ARAJO F O | 2008 | Materials Science and Engineering:2008，479，： | 1 |
| 19 | Sexual dysfunction in uraemic patients undergoing haemodialysis:predisposing and related conditions显示文摘 | Le(e)o R Sousa L Azinhais P | | 0，，： | 1 |
| 20 | Consensus formation on a triad scale-free net- work显示文摘 | Sousa A O | 2005 | Physica A: Statistical Mechanics and its Applica- tions2005，，348： | 1 |
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