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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | New way to guide light 显示文摘 | J C Night P St Russell | 2002 | Science2002，296，： | 2 |
| 3 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，96： | 1 |
| 4 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 5 | All si-lica single-mode optical fiber with photonic crystal cladding显示文摘 | Knight J C Birks T A Russell P St J | 1996 | Optics Letters1996，21，19： | 1 |
| 6 | All-silica single-mode optical fiber with photonic crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 7 | Adhesive small bowelobstruction after appendectomy in children:comparison between thelaparoscopic and open approach显示文摘 | Tsao K J St Peter S D Valusek P A | 2007 | Journal of Pediatric Surgery2007，42，6： | 1 |
| 8 | All-silica single-mode optic fiber with photonic with photonic Crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，15： | 1 |
| 9 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 10 | Demonstration of ultra-flattened dispersion in photonic crystal fibers显示文摘 | Reeves W H Knight J C P St J Russell | 2002 | Optics Express2002，10，14： | 1 |
| 11 | All-sillica single-mode optical fiber with photonic crystal cladding 显示文摘 | Knight J C Briks T A Russel P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 12 | Direct measurement of optical phase in the near field 显示文摘 | Knight J C Pottage J M Kakarantzas G Russell P St J | 2000 | Applied Physics Letters2000，76，5： | 1 |
| 13 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 14 | Anxiety and depression in sever chronic obstructive pulmonary disease; the effects of pulmonary rehabililation显示文摘 | Withers NJ Rudkin ST white P J | 1999 | J Cardopulm Rehabil1999，19，6： | 1 |
| 15 | End-lessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 16 | Effects of synthesis on electrochemical, structural and physical properties of solution phases of LiMnO3-LiNil-CoO2显示文摘 | Whitfield P St Niketic S Davidson I J | 2005 | Journal of Power Sources2005，146，12： | 1 |
| 17 | Giant fusiform aneurysm of the cerebral arteries 显示文摘 | LITTLE J R ST LOUIS P WEINSTEIN M | 1981 | Stroke1981，12，2： | 1 |
| 18 | Identification of heavy metal induced changes in the expression patterns of the translationally controlled tumour protein (TCTP) in the earth worm Lumbricus rubellus显示文摘 | Stürzenbaum S R Kille P Morgan A J | 1998 | Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression1998，1398，3： | 1 |
| 19 | All-Silica Single-Mode Optical Fiber with Photonic Crystal Cladding显示文摘 | Knight J C Birks T A Russell P St Jet ol | 1996 | Optics Letters1996，21，19： | 1 |
| 20 | Reversing click polarity may uncover auditory neuropathy in infants 显示文摘 | Berlin CI Bordelon J St John P | 1998 | Ear Hear1998，19，： | 1 |
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