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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation显示文摘 | During M J Kaplitt M G Stern M B | 2001 | Hum Gene Ther2001，12，12： | 1 |
| 3 | Compound specific δ13C analyses of leaf lipids from plants with differing carbon dioxide metabolisms显示文摘 | Collister J W Rieley G Stern B | 1994 | Organic Geochemistry1994，21，： | 1 |
| 4 | Cerebral infarction in young adults 显示文摘 | Kittner SJ Stern B J Wozniak M | 2004 | Neurology2004，50，9： | 1 |
| 5 | Maternal ast hma and microRNA regulation of soluble HLA-G in the airway 显示文摘 | Nicodemus-Johnson J Laxman B Stern RK | 2013 | J Allergy Clin Immunol2013，131，6： | 1 |
| 6 | Impact of human cytomegalovirus latent infection on myeloid progenitor cell gene expression显示文摘 | Slobedman B Stern J L Cunningham A L Abendroth A Abate D A Mocarski E S | 2004 | J Virol2004，78，8： | 1 |
| 7 | Geochemistry, geochronology and petrology of Monte Mucrone: An example of Eo-alpine eclogitization of Permian granitoids in the Sesia-Lanzo zone, western Alps, Italy显示文摘 | Hunziker J C Martinotti G,Stern W B | 1985 | Chemical Geology1985，52，： | 1 |
| 8 | Compound-specific δ13C analyses of leaf lipids from plants with differing carbon dioxide metabolisms显示文摘 | Collister J W Rieley G Stern B | 1994 | Org Geochem1994，21，： | 1 |
| 9 | Maternal asthma and microRNA regulation of soluble HLA-G in the airway显示文摘 | Nicodemus-Johnson J Laxman B Stern RK | 2013 | Allergy Clin Immunol2013，131，6： | 1 |
| 10 | Effect of initially limited resuscitation in a combined model of fluid - percussion brain injury and severe uncontrolled hemorrhagic shock 显示文摘 | Stern SA Zink B J Mertz M | 2013 | J Neurosurg2013，93，： | 1 |
| 11 | Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance 显示文摘 | Pollett J B Trudel S Stern D | 2002 | Blood2002，100，10： | 1 |
| 12 | Pulmonary hemo- dynamics in advanced COPD candidates for lung volume reduction surgery or transplantation 显示文摘 | THABUT G DAURIAT C STERN J B | 2005 | Chest2005，127，5： | 1 |
| 13 | MDS clinical diagnostic criteria for Parkinson's disease 显示文摘 | Postuma RB Berg D Stern M Poewe W Olanow CW Oertel W Obeso J Marek K Litvan I Lang AE Halliday G Goetz CG Gasser T Dubois B Chan P Bloem BR Adler CH Deuschl G | 2015 | Mov Disord2015，30，12： | 1 |
| 14 | Giant magnetoresistance in Co-Ag granular films preparedby low-energy cluster beam deposition显示文摘 | Parent F Tuaillon J Stern L B | 1997 | Phys Rev B1997，55，： | 1 |
| 15 | Adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted reproductive technology treatment显示文摘 | Stern J E Luke B Tobias M | 2015 | Fertility and sterility2015，103，6： | 1 |
| 16 | Combined marginal folate and riboflavin status affect homocysteine methylation in cuhured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation 显示文摘 | Lathrop Stern L Shane B Bagley P J | 2003 | J Nutr2003，133，9： | 1 |
| 17 | The Chlamydomonas reinhardtii plastid chromosome:islands of genes in a sea of repeats显示文摘 | MAUL J E LILLY J W CUI L DE PAMPHILIS C W MILLER W HARRIS E H STERN D B | 2002 | Plant Cell2002，14，11： | 1 |
| 18 | Combinatorial libraries, epitope structure and the prediction of protein conformations 显示文摘 | Gershoni J M Stern B Venisova G | 1997 | Immunol Today1997，18，3： | 1 |
| 19 | Giant magnetoresistance in Co-Ag granular films prepared by low-energy cluster beam deposition显示文摘 | J Tuaillon L B Stern | 1997 | Phys Rev B1997，55，3： | 1 |
| 20 | Solubility of carbon dioxide,methane,and propane in silicone polymers:Effect of polymer side chains显示文摘 | Hardy B J Stern S A | 1986 | J Polym Sci(Part B)1986，24，： | 1 |
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