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1Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients.Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein 2017World Journal of Gastroenterology2017,23,16:3
2Catalysis at the metal-support interface exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘BOWKER M JAMES D STONE P BENNETT R PERKINS N MILLARD L GREAVES J DICKINSON A 2003J Catal2003,217,2:1
3The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M 2010Science2010,330,6010:1
4Arabidopsis ovule is the target for Agrobactefium in planta vacuum infiltration transformation显示文摘Ye G N Stone D Pang S Z 1999Plant J1999,19,3:1
5Interferometric observations on far infra-red stimulated emissioin sources显示文摘GEBBIE H A STONE N W B FINDLAY F D 1964Nature1964,202,:1
6A survey method for characterizing daily life experience: The day reconstruction method (DRM) 显示文摘KAHNEMAN D KRUEGER A B SCHKADE D A SCHWARZ N STONE A A 2004Science2004,306,:1
7A Survey Method for Characterizing Daily Life Experience: The Day Reconstruction Method显示文摘Kahneman D Krueger A B Schkade D A Schwarz N Stone A A 2004Science2004,306,17:1
8Apolipoprotein J inhibits the migration,adhesion,and proliferation of vascular smooth muscle cells显示文摘Sivamurthy N Stone D H Logerfo F W 2001J Vasc Surg2001,34,:1
9Incidence and predictors of coronary stent thrombosis: Evidence from an international collaborative meta-analysis including 30 studies, 221,066 patients, and 4276 thromboses显示文摘Fabrizio D’Ascenzo Mario Bollati Fabrizio Clementi Davide Castagno Bo Lagerqvist Jose M. de la Torre Hernandez Juri?n M. ten Berg Bruce R. Brodie Philip Urban Lisette Okkels Jensen Gabriel Sardi Ron Waksman John M. Lasala Stefanie Schulz Gregg W. Stone Fl 2013International Journal of Cardiology2013,,:1
10Altered ubiquitin/proteasome expression in anastomotic intimal hyperplasia显示文摘Stone D H Sivamurthy N Contreras M A 2001J Vasc Surg2001,34,:1
11A Survey Method for Characterizing Daily Life Experience: The Day Reconstruction Method显示文摘Kahneman D Krueger A B Schkade D A Schwarz N Stone A A 2004Science2004,306,17:1
12A Survey Method for Characterizing Daily Life Experience: The Day Reconstruction Method显示文摘Kahneman D Krueger A B Schkade D A Sehwarz N Stone A A 2004Science2004,306,5702:1
13Simple estimates for the effects of mid-spatial-frequency surface errors on image quality 显示文摘YOUNGWORTH R N STONE B D 2000Applied Optics2000,39,13:1
14Application of FDTD to the prediction of RF radiation from heat- sinks显示文摘RYAN N J STONE D A CHAMBERS B Electronics Letters0,33,17:1
15Application of FD-TD to the prediction of RF radiation from heatsinks显示文摘N J Ryan D A Stone and B Chambers 1997Electronics Letters1997,33,17:1
16Arabidopsis ovule is the target for Agrobacterium in planta vacuum infiltration transformetion显示文摘Ye G N Stone D Pang S Z 1999Plant J1999,19,:1
17Attribution of polar warming to human influence显示文摘Gillett N P Stone D A Stott P A 2008Nat Geosci2008,1,:1
18The climate change risk management matrix for the grazing industry of northern Australia显示文摘Cobon D H Stone G S Carter J O Scanlan J C Toombs N R Zhang X K Willcocks J Mckeon G M 2009The Rangeland Journal2009,31,:1
19Altered ubiquitin/proteasome expression in anastomotic intimal hyperplasia显示文摘STONE D H SIVAMURTHY N CONTRERAS M A FITZGERALD L LOGERFO F W QUIST W C 2001J Vasc Surg2001,34,6:1
20The climate change risk management matrix for the grazing industry of northern Australia显示文摘Cobon D H Stone G S Carter J O Scanlan J C Toombs N R Zhang X Willcocks J McKeon G M 2009The Rangeland Journal2009,31,1:1
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