|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 3 | Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating fact or gene in intramuscular DNA immunization显示文摘 | Cho J H Lee S W Sung Y C | 1999 | Vaccine1999，17，910： | 2 |
| 4 | Optimal induction of hepatitis C virus envelope-specific immunity by bicistronic plasmid DNA inoculation with the granulocyte-macrophage-colony stimulating factor gene显示文摘 | Lee S W Cho J H Sung Y C | 1998 | J Virol1998，72，10： | 2 |
| 5 | CD24 expression predicts distant metastasis in extrahepatic bile duct cancer显示文摘AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer. | Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young Jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang Ja-June Jang Sung W Ha | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 6 | Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo显示文摘 | Xia Q Sung J Chowdhury W | 2006 | Cancer Res2006，66，14： | 1 |
| 7 | Management of stress urinary incontinence显示文摘 | Ward R M Sung V W | 2008 | Minerva Urol Nefrol2008，60，2： | 1 |
| 8 | The methodology to improve the performance of a selective catalytic reduction system installed in HRSG using computational fluid dynamics analysis显示文摘 | Jin M C Jeong W C Sung H H | 2006 | Environmental Engineering Science2006，23，5： | 1 |
| 9 | Numerical and experimental analysis of spray atomization characteristics of a GDI injector 显示文摘 | Sung W P Hyung J K | 2003 | KSME International Journal2003，17，3： | 1 |
| 10 | 显示文摘 | Sung H M Chen C J Ko W S | 1994 | IEEE Trans Magn1994，30，6： | 1 |
| 11 | Fixation of biological tissues with a naturally occurring erosslinking agent: Fixation rate and effects of pH, temperature, and initial fixative concentration显示文摘 | Sung H W Chang Y Liang I-L | 2000 | J Biomed Mater Res2000，52，： | 1 |
| 12 | A statistical model-based voice activity detection显示文摘 | Sohn J Kim N S Sung W | 1999 | IEEE Signal Process1999，16，： | 1 |
| 13 | Experimental study on transmission efficiency of a rubber V-belt CVT 显示文摘 | Chen T F Lee D W Sung C K | 1998 | Mechanism and Machine Theory1998，33，4： | 1 |
| 14 | Defense system in the biliaey tract against bacterial infection显示文摘 | Sung J Y Costerton J W Shaffer E A | 1992 | Dig Dis Sci1992，37，： | 1 |
| 15 | Dietary conjugated linoleic acid influnces the immune response of young and old C57BL/6NCrIBR mice显示文摘 | Michael G H Sung N H Dayong W | 1999 | Nutrition1999，129，： | 1 |
| 16 | Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent显示文摘 | Sung H W Chang Y Chiu C T | 1999 | Biomaterials1999，20，： | 1 |
| 17 | Effects of lamivudine on disease progression and development of liver cancer in advanced chronic hepatitis B:a prospective double-blined placebocontrolled trial显示文摘 | Liaw Y F Sung J J Y Chow W C | 2003 | Hepatology2003，，： | 1 |
| 18 | Second Flow Velocity Patterns in a Pulmonary Artery Model with Varying Degrees of Valvular Pulmonic Stenosis: Pulsatile in Vitro Studies 显示文摘 | H W Sung Ajit P Yoganathan | 1990 | J Biomech Eng (SO 148-0731)1990，112，2： | 1 |
| 19 | Feasibility study of a natural crosslinking reagent for biological tissue fixation 显示文摘 | Sung H W Huang R N Huang L H | 1995 | J Biomed Mater Res1995，42，： | 1 |
| 20 | Stability characteristics of Pt1Ni1/C as cathode catalysts in membrane electrode assembly of polymer electrolyte membrane fuel cell显示文摘 | CHO Y H JEON T Y YOO S J LEE K S AHN M KIM O H CHO Y H LIM J W JUNG N YOON W S CHOE H SUNG Y E | 2012 | Electrochim Acta2012，59，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员