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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Mapping autism risk loci using genetic linkage and chromosomal rearrangements 显示文摘 | Autism Genome Project Consortium Szatmari P Paterson A D | 2007 | Nature Gene2007，39，3： | 1 |
| 3 | Meta-analysis of pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy显示文摘 | Xiong J J Tan C L Szatmary P | 2014 | Br J Surg2014，101，10： | 1 |
| 4 | Petroleum formation by Fischer-Tropsch synthesis in plate tectonics显示文摘 | Szatmari P | 1989 | AAPG Bull1989，73，8： | 1 |
| 5 | Motor coordination and emotional-behavioral problems in children显示文摘 | Cairney J Veldhuizen S Szatmari P | 2010 | Curr Opin Psychiatry2010，23，4： | 1 |
| 6 | The prevalence of anxiety and mood problems among children with autism and Asperger syndrome显示文摘 | Kim JA Szatmari P Bryson SE | 2000 | Autism2000，4，2： | 1 |
| 7 | Generation of input signals for ArF Amplifers显示文摘 | S Szatmari F P Schafer | 1989 | Opt Soc Am B1989，6，10： | 1 |
| 8 | Interferometric multiplexing scheme for excimer lasers显示文摘 | Szatmari S Simon P | 1993 | Opt Commun1993，88，98： | 1 |
| 9 | Optimized operation of s hort-pulse KrF amplifiers by off-axis amplification显示文摘 | Almasi G Szatmari S and Simon P | 1992 | Opt Commun1992，88，23： | 1 |
| 10 | The classification of autism显示文摘 | Szatmari P | 2007 | Foreign Medical Sciences Clinical Radiological Fascicle2007，830，6： | 1 |
| 11 | Style and pattern of salt diapirs due to thin-skinned gravitational gliding, Campos and Santos basins, offshore Brazil显示文摘 | Demercian S Szatmari P Cobbold P R | 1993 | Teetonophysics1993，228，34： | 1 |
| 12 | A chart review of schizotypal personality disorders in children显示文摘 | Nagy J Szatmari P | | 0，，： | 1 |
| 13 | Mapping autism risk loci using genetic linkage and chromosomal rearrangements 显示文摘 | Szatmari P | 2007 | Nature Genetics2007，39，： | 1 |
| 14 | Vinpocetine for cognitive impairment and dementia显示文摘 | Szatmari S Whitehouse P | | 0，，01： | 1 |
| 15 | PPAR regulated ABCG2 expression confers cytoprotection to human dendritic cells 显示文摘 | SZATMARI I V MOSI G BRAZDA P | 2006 | J Biol Chem2006，281，23： | 1 |
| 16 | Overflow movements and behaviour problems:scoring and using a modification of Fogs' test显示文摘 | Szatmari P Taylor DC | 1984 | Dev Med Child Neurol1984，26，： | 1 |
| 17 | Radial gravitational gliding on passive margins 显示文摘 | Cobbold P R Szatmari P | 1991 | Tectonophysics1991，188，： | 1 |
| 18 | Single-crystal 40Ar-39Ar dating of pyrite:No fool's clock显示文摘 | Smith P E Evensen York N M Szatmari D de Oliveira P D C | 2001 | Geology2001，29，5： | 1 |
| 19 | A single-shout autocorrelator for ultraviolet with a variable time window显示文摘 | Schafer F P Jethwa J | 1990 | Rev Sci Instrum1990，61，： | 1 |
| 20 | Simiplified laser system for the generation of 60 fs pulses at 248nm显示文摘 | Szatmari S Schafer F P | 1988 | Opt Commun1988，68，： | 1 |
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