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| 1 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 2 | Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging显示文摘AIM: To assess how ascites and alpha-fetoprotein(AFP) added to the Barcelona Clinic Liver Cancer(BCLC) staging predict hepatocellular carcinoma survival.METHODS: The presence of underlying cirrhosis, ascites and encephalopathy, Child-Turcotte-Pugh(CTP) score, the number of nodules, and the maximum diameter of the largest nodule were determined at diagnosis for 1060 patients with hepatocellular carcinoma at a tertiary referral center for liver disease in Egypt. Demographic information, etiology of liver disease, and biochemical data(including serum bilirubin, albumin, international normalized ratio, alanine and aspartate aminotransferases, and AFP) were evaluated. Staging of the tumor was determined at the time of diagnosis using the BCLC staging system; 496 patients were stage A and 564 patients were stage B. Patients with mild ascites on initial ultrasound, computed tomography, or clinical examination, and who had a CTP score ≤ 9 were included in this analysis. All patients received therapy according to the recommended treatment based on the BCLC stage, and were monitored from the time of diagnosis to the date of death or date of data collection. The effect of the presence of ascites and AFP level on survival was analyzed.RESULTS:At the time the data were censored,123/496(24.8%)and 218/564(38.6%)patients with BCLC stages A and B,respectively,had died.Overall mean survival of the BCLC A and B patients during a three-year follow-up period was 31 mo[95%confidence interval(95%CI):29.7-32.3]and 22.7mo(95%CI:20.7-24.8),respectively.The presenceof ascites,multiple focal lesions,large tumor size,AFP level and CTP score were independent predictors of survival for the included patients on multivariate analysis(P<0.001).Among stage A patients,18%had ascites,33%had AFP≥200 ng/m L,and 8%had both.Their median survival in the presence of ascites was shorter if AFP was≥200 ng/m L(19 mo vs 24 mo),and in the absence of ascites,patients with AFP≥200 ng/m L had a shorter survival(28mo vs 39 mo).For stage B patients,survival for the corresponding groups was 12,18,19 and 22 mo.The one-,two-,and three-year survival rates for stage A patients without ascites and AFP<200 ng/m L were94%,77%,and 71%,respectively,and for patients with ascites and AFP≥200 ng/m L were 83%,24%,and 22%,respectively(P<0.001).Adding ascites and AFP≥200 ng/m L improved the discriminatory ability for predicting prognosis(area under the curve,0.618vs 0.579 for BCLC,P<0.001).CONCLUSION:Adding AFP and ascites to the BCLC staging classification can improve prognosis prediction for early and intermediate stages of hepatocellular carcinoma. | Asmaa I Gomaa Alzhraa Al-Khatib Wael Abdel-Razek Mohammed Saad Hashim Imam Waked | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 3 | 6-Min walk- test data in severe obstructive-sleep-apnea-hypopnea-syndrome ( OSAHS ) under continuous-positive-airway-pressure ( CPAP ) treatment显示文摘 | Ben Saad H Ben Hassen I Ghannouchi I | 2015 | Respiratory Medicine2015，109，5： | 1 |
| 4 | The use of Kleihauer-Betke stain in pregnant patients with abdominal trauma显示文摘 | Van den Veyver I Saade G Lockett L | 1993 | Am J Obstet Gynecol1993，168，： | 1 |
| 5 | Protective effect of grape seed proanthocyanidin extract against oxidativestress induced by cisplatin in rats显示文摘 | Yousef M I Saad A A EI-Shnawy L K | 2009 | Food and Chemical Toxicology2009，47，6： | 1 |
| 6 | Biopreservation by Lactobacillus paracasei in coculture with Streptococcus thermophilus in potentially probiotic and synbiotic fresh cream cheeses显示文摘 | BURITI F C A CARDARELLI H R SAAD S M I | 2007 | J Food Protect2007，70，1： | 1 |
| 7 | Giant dilatation of the umbilical vein显示文摘 | Fuster JS Benasco C Saad I | | 0，，： | 1 |
| 8 | Increased survival with enzalutamide in prostate cancer after chemotherapy 显示文摘 | Scher H I Fizazi K Saad F | 2012 | N EnglJMed2012，367，13： | 1 |
| 9 | Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats显示文摘 | YOUSEF M I SAAD A A EL-SHENNAWY L K | 2009 | Food and Chemical Toxicology2009，47，6： | 1 |
| 10 | Open partial nephrectomy for tumor in a solitary kidney:experience with 400 cases显示文摘 | FERGANY A F SAAD I R WOO L | 2006 | J Urol2006，175，16： | 1 |
| 11 | Cisplafin induced damage in kidney genomic DNA and nephrotoxicity in male rats: the protective effect of grape seed proanthocyanidin extract显示文摘 | SAAD A A YOUSSEF M I EL-SHENNAWY L K | 2009 | Food and Chemical Toxicology2009，47，7： | 1 |
| 12 | Coalitional game theory for com- munication networks 显示文摘 | Saad W Han Z I)ebbah M | 2009 | IEEE Signal Processing Magazine2009，26，5： | 1 |
| 13 | Simultane ous determination of preservatives in foodstuffs using high-performance liquid chromatography显示文摘 | SAAD B BARI M F SALEH M I | 2005 | J Chrom- atogr A2005，1073，39： | 1 |
| 14 | Increased survival with enzalu- tamide in prostate cancer after chemotherapy 显示文摘 | Scher H I Fizazi K Saad F | 2012 | N Engl J Med2012，367，13： | 1 |
| 15 | The main indications and techniques for vascular exclusion of the liver 显示文摘 | Chaib E Saad WA Fujimura I | 2003 | Am Gastroenterol2003，40，2： | 1 |
| 16 | Retrograde intrarenal surgery monotherapy versus shock wave lithotripsy for stones 10to 20 mm in preschool children:aprospective,randomized study显示文摘 | Mokhless I A Abdeldaeim H M Saad A | 2014 | J Urol2014，191，5： | 1 |
| 17 | Lumbar disc herniation in young children显示文摘 | Haidar R Ghanem I Saad S | 2010 | Acta Paediatr2010，99，1： | 1 |
| 18 | Lumbar disc herniation in young children显示文摘 | Haidar R Ghanem I Saad S | 2010 | Acta paediatr2010，99，1： | 1 |
| 19 | Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats显示文摘 | Yousef M I Saad A A EI-Shennawy L K | 2009 | Food Chem Toxicol2009，47，6： | 1 |
| 20 | Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats显示文摘 | YOUSEF M I SAAD A A EL-SHENNAWY L K | 2009 | Food and Chemical Toxicology2009，47，： | 1 |
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