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| 1 | Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway显示文摘绝经后的骨质疏松症严重地使受危险人的健康。没有副作用,寻找治疗学的药必要性大。我们的学习被设计调查是否 resveratrol, SIRT1 的收缩筋,能在骨质疏松症上并且到有有利效果探索内在的机制。老鼠骨质疏松症模型(卵巢切除术组, OVX ) 被双边的卵巢切除术建立。resveratrol 的三不同剂量被使用:5 mg/kg/d (低剂量,物件 LD ), 25 mg/kg/d (开媒介,物件 MD ), 和 45 mg/kg/d (开高度,物件 HD ) 。结果显示出那物件 LD 没在 OVX 改变上显示出任何重要效果,当时物件 MD 和物件 HD 显著地提高了骨质疏松症导致的减少的骨头矿物质密度(物件 MD 0.205 吗? | Jing Feng Shuai Liu Sai Ma Jian Zhao Wei Zhang Wei Qi Pengchong Cao Zheng Wang Wei Lei | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 70 |
| 2 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 3 | A comprehensive review on proppant technologies显示文摘The main function of traditional proppants is to provide and maintain conductive fractures during well production where proppants should meet closure stress requirement and show resistance to diagenesis under downhole conditions.Many different proppants have been developed in the oil&gas industry,with various types,sizes,shapes,and applications.While most proppants are simply made of silica or ceramics,advanced proppants like ultra-lightweight proppant is also desirable since it reduces proppant settling and requires low viscosity fluids to transport.Additionally,multifunctional proppants may be used as a crude way to detect hydraulic fracture geometry or as matrices to slowly release downhole chemical additives,besides their basic function of maintaining conductive hydraulic fractures.Different from the conventional approach where proppant is pumped downhole in frac fluids,a revolutionary way to generate in-situ spherical proppants has been reported recently.This paper presents a comprehensive review of over 100 papers published in the past several decades on the subject.The objectives of this review study are to provide an overview of current proppant technologies,including different types,compositions,and shapes of proppants,new technologies to pump and organize proppants downhole such as channel fracturing,and also in-situ proppant generation.Finally,the paper sheds light on the current challenges and emphasizes needs for new proppant development for unconventional resources. | Feng Liang Mohammed Sayed Ghaithan A.Al-Muntasheri Frank F.Chang Leiming Li | 2016 | Petroleum2016，2，1： | 15 |
| 4 | Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway显示文摘oncostatin M (OSM ) 能在 vivo 并且在 vitro 开始 cardiomyocyte dedifferentiation,这被报导了。导致 OSM 的 cardiomyocyte dedifferentiation 可能是为糖尿病的心肌症(DCM ) 的处理的一个新目标。这研究被设计在 cardiomyocyte dedifferentiation 和 DCM 的前进决定 OSM 的角色。一个老鼠 DCM 模型被建立在 vivo 评估 OSM 的效果。Echocardiography 被使用决定心脏的功能。染色的天狼星红被用来检测纤维变性区域。传播电子显微镜学被用来评估线粒体缺陷。实时聚合酶链反应和西方的污点分析被执行检测相对 mRNA 表情和 cardiomyocyte dedifferentiation 相关的蛋白质表情分别地。OSM 处理导致了类似的损害心脏的功能和心脏的超微结构缺陷到在 DCM 鼠标检测的那些。cardiomyocyte 的 dedifferentiation 标记的表达式(Runx1,和 -SM-actin) 与在控制组的那些相比在对待 OSM 的鼠标是起来调整的。为了推进,表明 OSM 的重要角色, OSM 受体大美人(O ko ) 老鼠被使用。在 O ko 老鼠, c 工具包的 cardiomyocytes dedifferentiation 标记, Runx1,和 atrial natriuretic 肽是下面调整的,与稀释 DCM 损害和废除 OSM/B-Raf/Mek/Erk 发信号小径。在结论,导致 OSM 的 cardiomyocyte dedifferentiation 在 DCM 的前进起一个关键作用。导致 OSM 的 cardiomyocyte dedifferentiation 的机制与通过 OSM 受体 O 表明小径的 B-Raf/Mek/Erk 被联系。 | Xiaotian Zhang Sai Ma Ran Zhang Shuang Li Di Zhu Dong Han Xiuiuan Li Congye Li Wei Yan Dongdong Sun Bin Xu Yabin Wang Feng Cao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 7 |
| 5 | Combined Effect of Smoking and Obesity on Coronary Heart Disease Mortality in Male Veterans:A 30-year Cohort Study显示文摘Objective Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans.This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.Methods A cohort of 1,268 male veterans from 22 veteran centers in Xi’an(Shaanxi Province,China)were followed up once every 2 years from February 1,1987 to October 30,2016.The endpoint was death from any cause.The hazard ratio(HR)of each risk factor and the 95%confidence interval(CI)were calculated using a multivariate Cox proportional hazard model.Results The total follow-up was 24394.21 person-years;each subject was followed up for a mean duration of 19.24 years.By the end of the study,of the 1,268 veterans,889 had died,363 were alive,and 16 were lost to follow-up.Cox regression analysis results revealed that current smoking(HR:1.552,95%CI:1.074–2.243),obesity(HR:1.625,95%CI:1.024–2.581),and the combined effect of the two factors(HR:2.828,95%CI:1.520–5.262)were associated with coronary heart disease mortality.Conclusion Our results suggest that obese veterans who smoke might be an important target population for coronary heart disease mortality control. | SAI Xiao Yong GAO Feng ZHANG Wen Yu GAO Meng YOU Jing SONG Yu Jian LUO Ting Gang SUN Yuan Yuan | 2021 | Biomedical and Environmental Sciences2021，34，3： | 5 |
| 6 | Defects engineering for high-performance perovskite solar cells显示文摘Metal halide perovskites have achieved great success in photovoltaic applications during the last few years.The solar to electrical power conversion efficiency(PCE)of perovskite solar cells has been rapidly improved from 3.9%to certified 22.7%due to the extensive efforts on film deposition methods,composition and device engineering.Further investigation on eliminating the defect states in perovskite absorbers is necessary to push forward the PCE of perovskite solar cells approaching the Shockley-Queisser limit.In this review,we summarize the defect properties in perovskite films and present methodologies to control the defects density,including the growth of large size crystals,photo-curing method,grain boundary and surface passivation,and modification of the substrates.We also discuss the defects-related stability and hysteresis issues and highlight the current challenges and opportunities in defects control of perovskite films. | Feng Wang Sai Bai Wolfgang Tress Anders Hagfeldt Feng Gao | 2018 | npj Flexible Electronics2018，2，1： | 4 |
| 7 | Analysis of formation and slope stability in Caofeidian Channel in Bohai Bay显示文摘In this paper, by studying bathymetric survey and shallow seismic detection data over multiple periods of history, the authors outline the geomorphic features of the Caofeidian Channel. The results of our studies indicate that the channel at the front end is dominated by erosion. The maximum water depth reaches 42.2 m, which sets the highest record for the water depth in Bohai Bay;the authors preliminarily conclude that the formation of the early channel occurred because the subsidence rate of the deep structure is slightly smaller than the deposition rate of the upper strata, and the Caofeidian Channel has existed for a long time, over 20 ka. The trending of the channel experienced a transition from the NS to the NE and then NW direction;the authors conclude that endogenic and exogenic processes, such as geological structures, the evolution of the ancient Luanhe River Delta, marine hydrodynamics, and human activity, jointly control the development and evolution of the geographic system in the Caofeidian sea area. The slope stabilities under the extreme conditions of a heavy storm and an earthquake are analyzed by performing simulations. | Hong-xian Chu Sai Mei Xiao-hui Gao Zhong-hua Fang Jing Feng | 2019 | China Geology2019，2，2： | 3 |
| 8 | Effects of cannabinoid receptor type 2 on endogenous myocardial regeneration by activating cardiac progenitor cells in mouse infarcted heart显示文摘Cannabinoid receptor type 2(CB2)activation is recently reported to promote proliferation of some types of resident stem cells(e.g.,hematopoietic stem/progenitor cell or neural progenitor cell).Resident cardiac progenitor cell(CPC)activation and proliferation are crucial for endogenous cardiac regeneration and cardiac repair after myocardial infarction(MI).This study aims to explore the role and possible mechanisms of CB2receptor activation in enhancing myocardial repair.Our results revealed that CB2receptor agonist AM1241 can significantly increase CPCs by c-kit and Runx1 staining in ischemic myocardium as well as improve cardiomyocyte proliferation.AM1241 also decreased serum levels of MDA,TNF-αand IL-6 after MI.In addition,AM1241 can ameliorate left ventricular ejection fraction and fractional shortening,and reduce fibrosis.Moreover,AM1241 treatment markedly increased p-Akt and HO-1 expression,and promoted Nrf-2 nuclear translocation.However,PI3K inhibitor wortmannin eliminated these cardioprotective roles of AM1241.In conclusion,AM1241 could induce myocardial regeneration and improve cardiac function,which might be associated with PI3K/Akt/Nrf2 signaling pathway activation.Our findings may provide a promising strategy for cardiac endogenous regeneration after MI. | WANG YaBin MA Sai WANG Qiang HU WenXing WANG DongJuan LI XiuJuan SU Tao QIN Xing ZHANG XiaoTian MA Ke CHEN JiangWei XIONG LiZe CAO Feng | 2014 | Science China(Life Sciences)2014，57，2： | 3 |
| 9 | Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway显示文摘BackgroundThe 导致了 pluripotent 干细胞(iPSC ) 在心肌的梗塞(MI ) 的细胞的治疗显示出大潜力,当它的申请被 cardiomyocyte 区别的低效率妨碍时。现在的学习被设计从老鼠在 cardiomyocyte 区别上调查 cardiotrophin-1 ( CT-1 )的效果导致的 pluripotent 干细胞( miPSCs )和内在的机制 involved.MethodsThe 为从 miPSCs 的 cardiomyocyte 区别的最佳的治疗状况与理想的集中( 10 ng/mL )和持续时间被建立(从到白天的白天 3 14 ) CT-1 管理。说明了胚胎的 cardiogenesis 的心脏的特定的基因的起来调整的表示被量的 RT-PCR 观察。 α 的提高的数量;肌浆球蛋白重链( α ;-MHC)和心脏的 troponin 我( cTn 我)积极房间被 immunofluorescence 在显微镜的分析揭示了的 CT-1 group.ResultsTransmission 电子染色和流动 cytometry 分析检测与 CT-1 对待的房间更好出现了,这组织了 sacromeric 结构和更多线粒体,它是成熟 cardiomyocytes 的词法特征。当与控制 group.ConclusionsThese 相比调查结果建议 CT-1 能提高 cardiomyocyte 区别以及导致的 pluripotent 干细胞导出的老鼠的成熟,西方的污点证明 CT-1 经由 JAK2/STAT3/Pim-1 小径部分从 miPSCs 支持 cardiomyocyte 区别由调整 JAK2/STAT3/Pim-1signaling 的 cardiomyocytes 小径。 | Tong LIU Ran ZHANG Tao GUO Sai MA Dong HAN Xiu-Juan LI Yan JIN Miao-Miao FAN Ya-Bin WANG Yun-Dai CHEN Feng CAO | 2015 | Journal of Geriatric Cardiology2015，12，6： | 2 |
| 10 | Novel sesquiterpenoids isolated from Chimonanthus praecox and their antibacterial activities显示文摘In the present study,four new sesquiterpenoids,chimonols A–D(compounds 1–4),together with four known compounds(5–8) were isolated from the Et OAc extract of Chimonanthus praecox Link.The structures of these new compounds were elucidated on the basis of spectroscopic techniques(UV,IR,MS,and 1 D and 2 D NMR),and their absolute configurations were established by comparing experimental and calculated electronic circular dichroism(ECD) spectra.Compounds 1–8 were evaluated for antimicrobial activities and the minimum inhibitory concentrations(MICs) were determined by the broth microdilution method in 96-well culture plates.Compounds 1,2,and 7 exhibited weak antibacterial effects for S.aureus(ATCC 6538),E.coli(ATCC 11775),and P.aeruginosa(ATCC 10145) with MIC values being 158–249 μg·mL^(-1).Compounds 3–7 showed activities against C.glabrata(ATCC 2001) and S.aureus(ATCC 43300) with MIC values being 128–197 μg·mL^(-1).Compounds 1–4 showed activity against S.aureus(ATCC 25923) with MIC values being 162–254 μg·mL^(-1).The present study provided a basis for future evaluation of these compounds as antibacterial agents. | LOU Hua-Yong ZHANG Yu MA Xiao-Pan JIANG Sai WANG Xiang-Pei YI Ping LIANG Guang-Yi WU Hong-Mei FENG Jing JIN Feng-Yun PAN Wei-Dong | 2018 | Chinese Journal of Natural Medicines2018，16，8： | 2 |
| 11 | The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells显示文摘 | Song Li-Bing Li Jun Liao Wen-Ting Feng Yan Yu Chun-Ping Hu Li-Juan Kong Qing-Li Xu Li-Hua Zhang Xing Liu Wan-Li Li Man-Zhi Zhang Ling Kang Tie-Bang Fu Li-Wu Huang Wen-Lin Xia Yun-Fei Tsao Sai Wah Li Mengfeng Band Vimla Band Hamid Shi | 2009 | Journal of Clinical Investigation2009，，12： | 2 |
| 12 | Effect of Tongluojiunao injection made from Sanqi(Radix Notoginseng) and Zhizi(Fructus Gardeniae) on brain microvascular endothelial cells and astrocytes in an in vitro ischemic model显示文摘OBJECTIVE: To explore the effect of Tongluojiunao injection(TLJN) prepared with Sanqi(Radix Notoginseng) and Zhizi(Fructus Gardeniae) on the interaction between brain microvascular endothelial cells(BMECs) and astrocytes in an in vitro ischemic model.METHODS: First, an in vitro model of cerebral ischemia in BMECs or astrocytes was established by oxygen-glucose deprivation(OGD). TLJN was used as a medicine of intervention. The OGD-injuredBMECs were cultured in various astrocyte-conditioned media. Cell activity, alkaline phosphatase(AKP) and γ-glutamyl transpeptidase(γ-GT) activity,interleukin-1 beta(IL-1β), and tumor necrosis factor alpha(TNF-α) content in BMECs were determined.Additionally, OGD-injured astrocytes were cultured in various BMEC-conditioned media. Cell activity, as well as expression of brain-derived neurotrophic factor(BDNF) and glial cell-derived neurotrophic factor(GDNF) in astrocytes, were detected.RESULTS: The results of paracrine signaling of normal BMECs or astrocytes showed a protective effect on each other: conditioned media from normal astrocytes improved cell viability, AKP, and γ-GT activity, and reduced IL-1β and TNF-α content of injured BMECs; conditioned media from normal BMECs improved cell viability and expression of BDNF and GDNF in injured astrocytes. However, once the BMECs or astrocytes were injured by OGD, the protective effect decreased or disappeared. The above-mentioned protective induction was effectively recovered by TLJN intervention.CONCLUSION: The therapeutic benefit of TLJN was achieved by recovering two-way induction between BMECs and astrocytes, enhancing activity of injured BMECs and astrocytes, stabilizing enzymatic barriers, promoting expression of neurotrophic factors, and inhibiting inflammatory cytokines. | Weihong Li Xingguang Li Qinghong Du Feng Li Yuan zhu Yang Liu Jie Ma Liangqin Wan Fanghe Li Sai Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
| 13 | Factors Affecting Patient Satisfaction with Community Health Service under the Gatekeeper System:A Cross-sectional Study in Nanjing,China显示文摘The gatekeeper policy has been implemented for approximately ten years on a pilot population in China. It is necessary to assess the satisfaction of patients utilizing community health service(CHS) under the gatekeeper system. Our study showed that the cognition of gatekeeper policy was associated with four dimensions including doctor‐patient relationships, information and support, organization of care, and accessibility(P < 0.001). One or more factors such as gender and self‐perceived health scores also affected their satisfaction. General practitioners must be prepared to focus on these aspects of information and support, organization of care, and accessibility as indicators of potential opportunities for improvement. Additionally, policymakers can improve patients' satisfaction with CHS by strengthening their awareness of the gatekeeper policy. | LI Wen Zhen GAN Yong ZHOU Yan Feng CHEN Ya Wen LI Jing KKANDAWIRE Naomiem HU Sai QIAO Yan LU Zu Xun | 2017 | Biomedical and Environmental Sciences2017，30，9： | 2 |
| 14 | Characterization and adsorption behaviors of a novel synthesized mesoporous silica coated carbon composite显示文摘A novel mesoporous silica coated carbon composite(denoted SEG) with hierarchical pore structure has been successfully prepared in an aqueous solution that contains triblock copolymer template, aluminum chloride, siliceous source and expanded graphite. Textural property and morphology of the SEG composite were characterized by the combination of X-ray diffraction, N_2 adsorption–desorption, scanning electron microscopy,transmission electron microscopy and Fourier transform infrared measurements. Results show that mesoporous silica is steadily and uniformly grown on the surface of the graphite slices and the thickness of the silica layer can be finely tuned according to the silica/C molar ratio in the initial reaction solution. This newly synthesized SEG composite shows greatly increased adsorption capacity to methylene blue than the pristine expanded graphite in the batch tests. Both Langmuir and Frendlich models were further used to evaluate the adsorption isotherms of methylene blue over expanded graphite and SEG samples with different silica contents. Finally, pseudosecond-order model was used to describe the kinetics of methylene blue over expanded graphite and the silica-carbon composites. | Sai Wang Songsong Xu Chengbao Liu Feng Chen Dongtian Wang Shouqing Liu Zhigang Chen Zhengying Wu | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 2 |
| 15 | Effects of the CVB -D on expression of the cerebral ischemia GAP -43 and Neurocan in the hypertensive rats 显示文摘 | Tan Feng Gu Wei Wan Sai ying | 2008 | Nerve Regeneration Research2008，3，04： | 1 |
| 16 | An ionic liquid-modified graphene based molecular imprinting electrochemical sensor for sensitive detection of bovine hemoglobin显示文摘 | Zonghua Wang Feng Li Jianfei Xia Lin Xia Feifei Zhang Sai Bi Guoyu Shi Yanzhi Xia Jingquan Liu Yanhui Li Linhua Xia | 2014 | Biosensors and Bioelectronics2014，，： | 1 |
| 17 | Separation of kaempferols in Impatiens balsamina flowers by capillary electrophoresis with electrochemical detection 显示文摘 | LIN Hua ZHAO Feng - peng L IAN Sai - chia | 2001 | Journal of- Chromatography A2001，，909： | 1 |
| 18 | An arginine derivative contained nanostructure lipid carriers with pH-sensitive membranolytic capability for lysosomolytic anti-cancer drug delivery显示文摘 | Sai Li Zhigui Su Minjie Sun Yanyu Xiao Feng Cao Aiwen Huang Hongying Li Qineng Ping Can Zhang | 2012 | International Journal of Pharmaceutics (-)2012，，1： | 1 |
| 19 | Real-time ultrasound-guided external intracerebral hemorrhage drain placement显示文摘We report a new minimally invasive technique utilizing interventional ultrasound for precise external intracerebral hemorrhage drain(EICHD) placement in pigs. | Cong Feng Sai Huang Li Chen Xuan Zhou Li-Li Wang Fa-Qin Lv Tan-Shi Li | 2021 | Military Medical Research2021，8，1： | 1 |
| 20 | Pedestrian Mortality between 2006 and 2010 in China: Findings from Non-police Reported Data显示文摘Pedestrian safety in China is an important but largely neglected issue,in part due to the substantial under-reporting within police data.In this study we aimed to examine changes in pedestrian fatality between 2006 and 2010 in China using non-police reported data.A multi-year study was conducted based on the mortality data | MA Sai HU Guo Qing LI Qing Feng ZHOU Mai Geng | 2013 | Biomedical and Environmental Sciences2013，26，10： | 1 |
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