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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | lntensity correlation functions for the colored gain-noisc model of dye lasers显示文摘 | TORAL R SAN MIGUEL M | 1990 | Phys Rev1990，42，11： | 1 |
| 3 | Enhanced plasmid maintenance in a CSRT upon square-wave oscillations in the dilution rate显示文摘 | Weber A E San K Y | 1988 | Biotechnology Letters1988，10，8： | 1 |
| 4 | Design details and characterization of all digital closed-loop interferometrie fiber optic gyroscope with superluminescent light emitting diode显示文摘 | elikel O San S E | 2009 | Optical Review2009，16，1： | 1 |
| 5 | Temperature activated ionic conductivity in gallium and indium phthalocyanines显示文摘 | SAN S E OKUTAN M NYOKONG T | 2011 | Polyhedron2011，30，6： | 1 |
| 6 | The antifungal drug ampho- tericin B promotes inflammatory cytokine release by a Tall-like receptor-and CD14-dependent mechanism显示文摘 | San K Mambula SS Latz E | 2003 | J Biol Chem2003，278，37： | 1 |
| 7 | Establishment of All Digital Closed-Loop Interferometric Fiber-Optic Gyroscope and Scale Factor Comparison for Open-Loop and All Digital Closed-Loop Configurations显示文摘 | Celikel O San S E | 2009 | IEEE Sensors Journal2009，9，2： | 1 |
| 8 | Mode of action of two inhibitory peptides from beptad repeat domains of the fusion protein of Newcastle disease virus显示文摘 | San Román K Villar E Munoz-Barroso I | 2002 | International Journal of Biochemistry & Cell Biology2002，34，10： | 1 |
| 9 | Tuberculous pleurisy:a study of 254 patients显示文摘 | Valdés L Alvarez D San José E | 1998 | Arch Intern Med1998，158，18： | 1 |
| 10 | A European perspective on intravascular catheter-related infections:report on the microbiology workload,aetiology and antimicrobial susceptibility显示文摘 | Bouza E San Juan R Munoz P | 2004 | Clin Microbiol Infect2004，10，9： | 1 |
| 11 | Automatic source camera identification using the intrinsic lens radial distortion 显示文摘 | San Choi K Lain E Y Wong K K Y | 2006 | Optics ex- press2006，14，11： | 1 |
| 12 | Effects of high energy milling on some functional properties of jicama starch ( Pachyrrhizus erosus L Urban) and cassava starch (Manihot esculenta Crantz ) 显示文摘 | Marttnez-Bustos F Lepez-Soto M San Martin-Martinez E | 2007 | Journal of Food Engineering2007，78，4： | 1 |
| 13 | Changes in the serum levels of interleukin-17/interleukin-23 during acute rejection in liver transplantation显示文摘 | Fabrega E Lopez-Hoyos M San Segundo D | 2009 | Liver transpl2009，15，6： | 1 |
| 14 | Crohn?s Disease Patients Carrying Nod2/CARD15 Gene Variants Have an Increased and Early Need for First Surgery due to Stricturing Disease and Higher Rate of Surgical Recurrence显示文摘 | Manuel Alvarez-Lobos Juan I. Arostegui Miquel Sans Dolors Tassies Susana Plaza Salvadora Delgado Antonio M. Lacy Josep M. Pique Jordi Yagüe Julián Panés | 2005 | Annals of Surgery2005，，5： | 1 |
| 15 | Mi- croRNA expression profi ling in imatinib-resistant chronic myeloid leukemia patients without clinically signifi cant ABLI-mutations显示文摘 | San Jose-Eneriz E Roman-Gomez J Jimenez-Velasco A | 2009 | Molecular Cancer2009，8，： | 1 |
| 16 | Diagnosis of tuberculousp leurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon 显示文摘 | Valdes L San Jose E Alvarez D | 1993 | Chest1993，103，： | 1 |
| 17 | Influence of Al and Ni concentration on the martensitic transformation in Cu Al Ni shape-memory alloys 显示文摘 | RECARTE V PEREZ-SAEZ R B BOCANEGRA E H NO M L SAN JUAN J | 2002 | Metall Mater Trans A2002，33，： | 1 |
| 18 | The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina显示文摘 | San Giovanni J P Chew E Y | 2005 | Progress in Retina and Eye Research2005，24，1： | 1 |
| 19 | Diagnostic value of aden-osine deaminase and ysozyme in tuberculous pleurisy 显示文摘 | San Jose E Valdes L Sarandeses A | 1992 | Clin Chem Acta1992，209，12： | 1 |
| 20 | Diagnosis of tuberculous pleurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon-gamma显示文摘 | Valdes L San Jose E Alvarez D | 1993 | Chest1993，103，： | 1 |
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