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| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | Age-related changes in seminal polymorphonuclear elastase in men with asymptomatic inflammation of the genital tract显示文摘瞄准:在男生殖道调查年龄相关的煽动性的事件。方法:总共 4 265 随机收集了出席的中心的 andrologicaloutpatient 诊所的病人皮肤学和 Andrology , Giessen 的大学,德国,精液体积,pH值,精子集中,总数和进步精子活动性, polymorphonuclear ( PMN )的集中弹性硬蛋白酶,peroxidase积极的房间和fructose 的数字被测量并且与病人的年龄相关。结果:当精液体积,活动性和 fructose 都与年龄否定地相关时,精子集中, PMN 弹性硬蛋白酶和 pH 值显示出积极关联。男生殖道发炎的流行(是由 PMN 弹性硬蛋白酶 >
250ng/mL 定义) 并且它的严厉显著地增加了。PMN 弹性硬蛋白酶没与精子活动性相关。尽管精囊功能的一个标记与 PMN 弹性硬蛋白酶层次 Fructose, peroxidase 积极的房间的数字和精子活动性显示出一种重要否定关系。结论:PMN 弹性硬蛋白酶层次的 Thesignificant 增加作为在老人的男生殖道发炎的标记看起来在本地免疫的年龄相关的变化指示规章的机制。Becausethere 不是有精子活动性的 PMN 弹性硬蛋白酶的协会,这酶的直接禁止的效果能被排除。 | Raft Henkel Gesa Maaβ Andreas Jung Gerhard Haidl Wolf-Bernhard Schill Hans-Christian Schuppe | 2007 | Asian Journal of Andrology2007，9，3： | 16 |
| 3 | 青藏高原北部异常SKS分裂成因的初步探讨——被熔体强化的岩石圈各向异性显示文摘当人们试图解释青藏高原异常的剪切波分裂成因时 ,以下的问题让人们感到困惑 :( 1 )为什么异常大的SKS分裂延时 ( 1 .91— 2 .4s)出现在青藏高原北部Sn波缺失区 ;( 2 )为什么分裂延时突变 ( 1 .47s和 1 .0 9s)出现在Sn波缺失区的边缘 ;( 3)为什么快波极化方向(FPD)与地表大规模的构造走向之间存在约 2 0°— 30°的偏差 .本文在综合分析流变学实验和岩石物理学实验研究成果、青藏高原地质和地球物理资料的基础上 ,提出青藏高原北部地震波各向异性受岩石圈地幔主要矿物的晶格优选方位 (LPO)和熔体的定向分布 (MPO)的双重控制 ,并模拟计算了MPO对青藏高原北部岩石圈地幔各向异性强度的贡献 .研究结果表明 ,由MPO强化的青藏高原北部岩石圈地幔各向异性强度可达 1 0 % ,相应的各向异性层厚度平均为 94km .该结果为研究区SKS分裂的成因解释以及造山带深部地质过程的研究提供了新的约束条件 . | 杨晓松 金振民 马瑾 E. Huenges F. Schilling | 2002 | 地球物理学报2002，45，6： | 15 |
| 4 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 5 | HIGH-ORDER WENO SIMULATIONS OF THREE-DIMENSIONAL RESHOCKED RICHTMYER-MESHKOV INSTABILITY TO LATE TIMES:DYNAMICS,DEPENDENCE ON INITIAL CONDITIONS,AND COMPARISONS TO EXPERIMENTAL DATA显示文摘The dynamics of the reshocked multi-mode Richtmyer-Meshkov instability is investigated using 513×257 2three-dimensional ninth-order weighted essentially nonoscillatory shock-capturing simulations.A two-mode initial perturbation with superposed random noise is used to model the Mach 1.5 air/SF6 Vetter-Sturtevant shock tube experiment. The mass fraction and enstrophy isosurfaces,and density cross-sections are utilized to show the detailed flow structure before,during,and after reshock.It is shown that the mixing layer growth agrees well with the experimentally measured growth rate before and after reshock.The post-reshock growth rate is also in good agreement with the prediction of the Mikaelian model.A parametric study of the sensitivity of the layer growth to the choice of amplitudes of the short and long wavelength initial interfacial perturbation is also presented.Finally,the amplification effects of reshock are quantified using the evolution of the turbulent kinetic energy and turbulent enstrophy spectra,as well as the evolution of the baroclinic enstrophy production,buoyancy production,and shear production terms in the enstrophy and turbulent kinetic transport equations. | Oleg Schilling Marco Latini | 2010 | Acta Mathematica Scientia2010，30，2： | 9 |
| 6 | 297例视网膜母细胞瘤的临床病理研究显示文摘目的探讨视网膜母细胞瘤(retinoblastoma,Rb)脉络膜浸润的形态学分期标准,为在统一的标准下进一步对该肿瘤进行临床病理研究。方法对摘除的297例原发性Rb患者的眼球组织标本,进行光镜观察。结果肿瘤侵犯球壁组织在形态学上可分为4期(色素上皮脉络膜分期):Ⅰ期,仅为视网膜色素上皮层受侵犯,玻璃体膜结构完整。Ⅱ期,玻璃体膜结构被破坏,脉络膜毛细血管层尚未被侵犯。Ⅲ期,肿瘤浸润深达脉络膜,靠近毛细血管层的中血管层内的小范围区域。Ⅳ期,大范围脉络膜浸润,巩膜可同时受累。Ⅳ期病死率为115%,Ⅰ~Ⅲ期的病死率为04%。结论色素上皮脉络膜分期可作为研究不同个体肿瘤细胞浸润程度进行比较的统一标准。 | 杨红 HARALD SCHILLING RUDOLF EFFERT ACHIM WESSING | 1999 | 中华眼科杂志1999，35，4： | 9 |
| 7 | Fertility and sexual life of men after their forties and in older age显示文摘Owing to the demographic development, the aging male will require more consideration in future. In contrast to a rapid decline of estradiol during menopause in women, the process of aging in the male is retarded and subject to high individual variations. Impairment of spermatogenesis is observed as a continuous process occurring over decades. However, only about 50% of men in their eighties show complete loss of fertility. In principle, spermatogenesis may be retained well into senescence. Of importance for the individual health condition is the fact that the number of Leydig cells declines with advancing age. Thus, altered sex hormone concentrations in aging men result from both functional disturbances and a gradual reduction in Leydig cells. Furthermore, an impaired feed-back mechanism of the pituitary-gonadal axis occurs, with disappearance of the circadian testosterone (T) rhythm. LH and FSH levels are increased, and a reduced bioavailability of sex hormones is observed. Lower total testosterone concentrations in men over 60 years are accompanied by clinical signs of reduced virility, such as decreased muscle mass and strength as well as reduced sexual hair growth and libido. An age-related decline in androgen secretion and plasma testosterone levels therefore suggests the use of androgen supplementation. However, there is a lack of risk-benefit long-term studies. Increased research in the male is mandatory to meet the requirements of the aging population. This should include the availability of precise epidemiological data about the frequency of partial androgen deficiency in aging males (PADAM). | Wolf-Bernhard Schill | 2001 | Asian Journal of Andrology2001，3，1： | 8 |
| 8 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 9 | IL-8在食管癌中表达对肿瘤血管形成及患者预后的影响显示文摘目的研究白细胞介素8(IL8)在食管癌组织中的表达变化,以及此变化对肿瘤血管形成、患者预后的影响。方法利用实时逆转录聚合酶链反应(realtimeRT PCR)和免疫组织化学技术检测食管癌及正常组织中IL8mRNA和蛋白表达,并采用Ⅷ因子相关抗原(FⅧRAg)检测微血管密度。结果食管癌组织中IL8mRNA及蛋白表达显著高于正常组织。IL8mRNA高表达与远处淋巴结转移、微血管高密度、生存时间短(<26个月)、早期复发(<16个月)有关(均P<0.05)。癌组织中微血管密度比周围正常组织高(P<0.01)。结论在食管癌中,IL8mRNA高表达的患者发生转移机率高,复发早,生存时间短;IL8可以作为一个判定食管癌预后的指标。 | 苏铁芬 Bettina Tilton 袁永辉 李娜萍 Martin Schilling 吴人亮 | 2005 | 华中科技大学学报(医学版)2005，34，4： | 7 |
| 10 | 偏光显微镜在壁画颜料分析中的应用显示文摘近年来偏光显微镜在文物保护上的应用越来越广泛 ,尤其是在壁画地仗、颜料成分及病害分析等方面 ,本文列举了偏光显微镜在颜料分析中多方面的应用。 | 马赞峰 李最雄 苏伯民 Michael R Schilling 林博明 | 2002 | 敦煌研究2002，，4： | 6 |
| 11 | Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study显示文摘High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures.Here,we demonstrate that an all-optical ultrasound transducer,through which light guided by optical fibers is used to generate and receive ultrasound,is suitable for real-time invasive medical imaging in vivo.Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser.The interrogation of a high-finesse Fabry–Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception.This transducer was integrated within a custom inner transseptal needle(diameter 1.08 mm;length 78 cm)that included a metallic septum to acoustically isolate the two optical fibers.The use of this needle within the beating heart of a pig provided unprecedented realtime views(50 Hz scan rate)of cardiac tissue(depth:2.5 cm;axial resolution:64μm)and revealed the critical anatomical structures required to safely perform a transseptal crossing:the right and left atrial walls,the right atrial appendage,and the limbus fossae ovalis.This new paradigm will allow ultrasound imaging to be integrated into a broad range of minimally invasive devices in different clinical contexts. | Malcolm C Finlay Charles A Mosse Richard J Colchester Sacha Noimark Edward Z Zhang Sebastien Ourselin Paul C Beard Richard J Schilling Ivan P Parkin Ioannis Papakonstantinou Adrien E Desjardins | 2017 | Light(Science & Applications)2017，6，1： | 6 |
| 12 | 纸条检测法对第85窟壁画空鼓灌浆脱盐效果的评估显示文摘实验得出不损伤壁画的纸条检测法与壁画表面盐分含量的关系,并以此为根据,采用纸条法测定壁画表面盐分的含量状态,评价壁画空鼓灌浆后脱盐的效果。结果表明壁画空鼓灌浆所带入的水分激活了地仗中的盐分,使盐分运移并大量地富集到壁画的表面。保护笔的脱盐效果十分显著,纸条法测得保护笔脱盐后Cl-浓度降低约10个ppm,相当于保护笔脱盐可以减少了壁画表面地仗中所含1.6%的Cl-的量,即可以去除掉未灌浆区域壁画表面盐分的80%。实验证明纸条法可以应用于壁画脱盐效果的检验。 | 陈港泉 Michael Schilling 李燕飞 Neville Agnew Joy Keeney Stephen Rickerby 于宗仁 Lisa Shekede | 2007 | 敦煌研究2007，，5： | 5 |
| 13 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 14 | 脉络膜恶性黑色素瘤中Ki-67的表达和肿瘤主要组织病理特性的关系显示文摘目的:利用抗Ki-67单克隆抗体对石蜡包埋的葡萄膜黑色素瘤组织作免疫组化染色,研究细胞增殖活性和肿瘤重要的组织病理特性之间的关系。方法:对1988~1997年间57例葡萄膜黑色素瘤眼球摘除眼作组织病理检查和Ki-67免疫组化染色。所有患眼在接受眼球摘除术前均没有接受过其他治疗。结果:Ki-67指数分布范围为0~4.89,平均(0.75±1.02)。含有上皮样细胞肿瘤的Ki-67指数高于梭形细胞肿瘤,差异具显著性(P=0.037)。大肿瘤组的Ki-67指数比中等大肿瘤组高,两者比较差异有高度显著性(P=0.007)。肿瘤大小和细胞类型间存在内在的相关性(X2=4.528,P<0.05),大肿瘤多为上皮样细胞肿瘤而中等大肿瘤则多为恶性度较低的梭形细胞肿瘤。未发现Ki-67表达与肿瘤位置,肿瘤巩膜外蔓延及年龄有关。结论:Ki-67表达与肿瘤的组织细胞类型及大小有关。眼科学报2001;17:114~117。 | 梁建宏 黎晓新 易长贤 Harald Schilling | 2001 | 眼科学报2001，17，2： | 5 |
| 15 | Drought Adaptation and Coping Strategies Among the Turkana Pastoralists of Northern Kenya显示文摘This study highlights drought characteristics and the many responses to drought stresses employed by Turkana pastoralists of northwestern Kenya. Multiple data sources, including socioeconomic interviews with 302 households, focus group discussions, and informal interviews with pastoralists were used to capture various aspects of drought and drought adaptation and coping practices.Standardized precipitation index derived from long-term rainfall data obtained from the Kenya Meteorological Service was used to quantify different degrees of drought intensity between 1950 and 2012. Results revealed that extreme drought events were increasingly frequent, and have impacted negatively on pastoral livelihoods. In order to adapt to or cope with climatic anomalies, households are using a variety of strategies. In addition to the traditional short-term coping mechanisms, the long-term adaptation strategies used include diversification of livelihood sources; livestock mobility to track forage and water resources;diversification of herd composition to benefit from the varied drought and disease tolerance, as well as fecundity of diverse livestock species; and sending children to school for formal education as a long term investment expected to pay back through income from employment. Policies anddevelopment interventions that reduce risks, diminish livelihood constraints, and expand opportunities for increased household resilience to drought are critical complements to the existing pastoral strategies. | Francis Opiyo Oliver Wasonga Moses Nyangito Janpeter Schilling Richard Munang | 2015 | International Journal of Disaster Risk Science2015，6，3： | 5 |
| 16 | Diagnosis of obscure gastrointestinal bleeding by intraoperative enteroscopy in 81 consecutive patients显示文摘瞄准:为了由与流血调查一系列选择病人分析 intra 起作用的肠寄生物(IOE ) 的结果和复杂并发症,怀疑了从小肠发源。方法:81 个病人(吝啬的年龄:65 年) 包括 40,男性(49.4%) 和有阴暗胃肠的流血的 41 女性(50.6%) 经历了在 1990 和 2004 之间的 IOE。病人从一个数据库被识别,数据回顾地从病人的图表被选择。所有病人在 IOE 前经历了至少一非诊断的 esophagogastroduodenoscopy,结肠镜检查,标准肠寄生物和否定腹的超声扫描。结果:在病人的中部的最小的血红素水平是 59 + 15 g/L 并且 72.8% 病人以前要求了包装红血球的输送。流血来源在 68 被检测(84%) 病人在 IOE 期间。Angiodysplasiae 在 44 个病人(54.3%) 被发现, 9 个病人(11.1%) 被溃疡在小肠影响。在小肠的一个肿瘤在另外一个被检测 6 个病人。治疗在大多数病人由 argon-plasma-coagulation,外科的缝术或有限切除术组成了。结论:Intra 起作用的肠寄生物仍然为怀疑的小肠流血的诊断被使用。最近的开发象无线的囊内视镜检查法和两倍汽球肠寄生物那样,以后可以导致 IOE 的代替。 | Ralf Jakobs Dirk Hartmann Claus Benz Dieter Schilling Uwe Weickert Axel Eickhoff Klaus Schoenleben Juergen F Riemann | 2006 | World Journal of Gastroenterology2006，12，2： | 5 |
| 17 | Testing semiochemicals from aphid, plant and conspecific: attraction of Harmonia axyridis显示文摘Harmonia axyridis 智慧女神雅典娜(翘目:Coccinellidae ) 是影响几个行业协会的动力学和作文的一个侵略硬币。现在,没有生物控制方法是可得到的减少这有害 coccinellid 的人口。引诱剂和 semiochemicals 似乎是到是最好的选择,但是仅仅很少研究在这亚洲女士甲壳虫上测试了 semiochemicals 的影响。在这个工作,通过风隧道实验,从蚜虫的 semiochemicals (Z, E-nepetalactone,[E ]-- 从 coccinellids 的 farnesene, -pinene 和 -pinene),([-]--caryophyllene) 并且从荨麻 Urtica dioica L。作为潜在的引诱剂被评估。荨麻不稳定的混合物([Z ]-3-hexenol 并且[E ]-2-hexenal) 用一台 Clevenger 仪器被提取?并且由 headspace 气体 chromatographymass 光谱学识别了。当时,在风隧道实验,蚜虫警报 pheromone 的主要部件以及蚜虫的一个部件,性 pheromone 强烈吸引了亚洲女士甲壳虫的两性(-)-- caryophyllene 仅仅吸引了很少个人并且没在男性上有影响。象(Z)-3-hexenol 一样的荨麻摘录面向到气味的男性和女性采购原料。就算,(E)-2-hexenal 被显示没在女性上有效果这片绿叶不稳定的吸引的男性。因为 Z, E-nepetalactone 在风隧道实验作为最有效的引诱剂被识别,这不稳定也在一块土豆地里被测试在哪儿 H。axyridis 被显示了对这 semiochemical 作出回应。这研究加亮那 Z, E-nepetalactone 面向了亚洲女士甲壳虫 H。在天赋下面的 axyridis 调节,显示这不稳定的混合物能当然为有效生物控制帮助对这个侵略硬币来临。 | Pascal D. Leroy Thomas Schillings Julien Farmakidis Stephanie Heuskin Georges Lognay Francois J. Verheggen Yves Brostaux Eric Haubruge Frederic Francis | 2012 | Insect Science2012，19，3： | 5 |
| 18 | Drug treatment of male fertility disorders显示文摘Drug treatment remains an active domain in the therapy of male fertility disorders. Although there are only a few conditions that allow causal treatment, rational approaches are possible in many cases. Best results are obtained in cases requiring an anti-inflammatory treatment and in patients with an impaired sperm transport. High-dosage administration of FSH is a promising new development, aimed particularly at improving the disturbed sperm structures. A careful diagnostic work-up with elucidation of the underlying disease is essential to achieve a successful therapy. | Gerhard Haidl Frank-Michael Kohn Wolf-Bernhard Schill | 2000 | Asian Journal of Andrology2000，2，2： | 4 |
| 19 | CAD-VR geometry and meta data synchronization for design review applications显示文摘In this paper we present the MEMPHIS middleware framework for the integration of CAD geometries and assemblies with derived Virtual Reality (VR) models and its specific meta data and attributes. The goal of this work is to connect real time VR applications, especially for the Design Review, with enterprise software storing and managing CAD models (Product Data Man- agement—PDM). The preparation of VR models requires expert knowledge, is time consuming, and includes selection of required CAD data, tessellation, healing of unwanted gaps, applying materials and textures, and special surface and light effects. During the Design Review process, decisions are made concerning the choice of materials and surface forms. While materials can be switched directly on the VR model, the modification of part geometries must be made on the CAD model. Our system synchronizes modi- fications of the original CAD geometries and of attributes that are relevant for the realistic rendering using the PLM Services standard. Thus, repeated work for the VR preparation can be avoided. | SCHILLING Arne KIM Seokryul WEISSMANN Daniel TANG Ziying CHOI Sangsu | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，9： | 3 |
| 20 | Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: Patterns of failure显示文摘 | Nicolaus Andratschke Frank Zimmermann Eva Boehm Sabine Schill Christine Schoenknecht Reinhard Thamm Michael Molls Carsten Nieder Hans Geinitz | 2011 | Radiotherapy and Oncology2011，，2： | 3 |
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