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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Lariat ethers-synthesis and cation binding of macrocyclic polyethers possessing axially disposed secondary donor groups 显示文摘 | Gokel G W Schultz R A Dishong D M | 1980 | J Chem Soc Chem Commun1980，，： | 2 |
| 3 | The role of policy in improving diets: experiences from the Pacific obesity prevention in communities food policy project显示文摘 | Thow A M Snowdon W Schultz J T | 2011 | Obesity Reviews2011，12，2： | 1 |
| 4 | Quantitative determination of fluorinated alkyl substances by large-volume-injection liquid chromatography tandem mass spectrometry-characterization of municipal wastewaters 显示文摘 | Schultz M M Barofsky D F Field J A | 2006 | Environment Science Technology2006，40，： | 1 |
| 5 | Glass formability and fragility of Fe61Co9-xZrsMosWxB17(x=0 and 2) bulk metallic zlassy alloys 显示文摘 | WANG W M GEBERT A ROTH S KUEHN U SCHULTZ L | 2008 | Intermetallics2008，16，： | 1 |
| 6 | Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10 deficient mice显示文摘 | SCHULTZ M VELTKAMP C DIELEMAN L A | | 0，，02： | 1 |
| 7 | Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans显示文摘 | Parikh S M Mammoto T Schultz A | 2006 | PLoS Med2006，3，3： | 1 |
| 8 | Bronchoalveolar coagulation and fibrinolysis in endotoxemia and pneumonia显示文摘 | Levi M Schultz M J Rijneveld A W | 2003 | Crit Care Med2003，31，4： | 1 |
| 9 | Characteristics and capabilities of the hyperspectral imaging microscope显示文摘 | Schultz R A Garner H R | 2002 | IEEE Engineering in Medicine and Biology2002，21，4： | 1 |
| 10 | Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evalua- tion of CDK1/cyelin B inhibition, and in vitro antitumor activity显示文摘 | SCHULTZ C LINK A LEOST M | 1999 | J Med Chem1999，42，： | 1 |
| 11 | Monitoring acetylsalicylic acid effects with the platelet function analyzer PFA-100 显示文摘 | Feuring M Schultz A Losel R | 2005 | Semin Thromb Hemost2005，31，4： | 1 |
| 12 | Regulation of stage-specific nuclear translocation of Dnmtl during preimplantation mouse development 显示文摘 | Doherty A S Bartolomei M S Schultz R M | 2002 | Developmental Biology2002，242，2： | 1 |
| 13 | Corrosion behaviour of Nd-Fe-B permanent magnetic alloys 显示文摘 | Schultz L El-Aziz A M Barkleit G | 1999 | Mater Sci & Eng A1999，267，： | 1 |
| 14 | Quantitative determination of fluorinated alkyl substances by large-volume-injection liquid chromatography tandem mass spectrometry-characterization of municipal wastewaters显示文摘 | SCHULTZ Melissa M BAROFSKY Douglas F FIELD Jennifer A | 2006 | Environmental Science & Technology2006，40，1： | 1 |
| 15 | Fluorochemical mass flowsin a municipal wastewater treatment facility显示文摘 | Schultz M M Higgins C P Huset C A | 2006 | Environmental Scienceand Technology2006，40，23： | 1 |
| 16 | Etiology and incidence of pressure ulcers insurgical patients 显示文摘 | Schultz A Bien M Dumond K etal | 1999 | AORN J1999，70，3： | 1 |
| 17 | RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse显示文摘 | Balboula A Z Stein P Schultz R M | 2015 | Biol Reprod2015，92，4： | 1 |
| 18 | Etiology and incidence of pres- sure ulcers in surgical patients显示文摘 | Schultz A Bien M Dumond K | 1999 | Aorn J1999，70，3： | 1 |
| 19 | BMP-2 but not VEGF or PDGF in fibrin matrix supports bone healing in a delayed-union rat model显示文摘 | Kaipel M Schutzenberger S Schultz A | 2012 | J Orthop Res2012，30，10： | 1 |
| 20 | Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites显示文摘 | Bahn A Ljubojevic M Lorenz H Schultz C Ghebremedhin E Ugele B | 2005 | Am J Physiol Cell Physiol2005，289，5： | 1 |
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