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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 3 | Confocal mi-croscopy study of phase morphology evolution in epoxy/polysiloxanethermosets显示文摘 | Cabanelas J C Serrano B Gonzalez M G | 2005 | Polymer2005，46，： | 1 |
| 4 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 显示文摘 | SERRANO M HANNON G J BEACH D | 2003 | Nature2003，366，6456： | 1 |
| 5 | Pea protein as a substi- tute of soya bean protein in diets for young pigs:Effects on productivity and digestive traits显示文摘 | Valencia D G Serrano M P Centeno C L | 2008 | Livestock Science2008，118，： | 1 |
| 6 | A CMOS photodiode array with in-pixel data acquisition system for computed tomography 显示文摘 | STEADMAN R SERRANO F M VOGTMEIER G | 2004 | IEEE J Sol Sta Circ2004，39，7： | 1 |
| 7 | Competive sorption of cadmium and lead in acid soils of centml spain显示文摘 | Serrano S Garrido F Campbell C G | 2005 | Geoderma2005，124，： | 1 |
| 8 | Beneficial effects of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta显示文摘 | Serrano M A Brites D Larena M G | 1998 | J Hepatol1998，28，： | 1 |
| 9 | A new regulatory motif in cell -cycle control causing specific inhibition of cycle D/CDK4显示文摘 | Serrano M Hannon G J Beach D | 1993 | Nature1993，366，： | 1 |
| 10 | Yeast plasma membrane ATPase is essential for growth and has homology with (Na^+┼K+) , K+ and Ca^2+-ATPase显示文摘 | Serrano R Kielland - Brandt M C Fink G R | 1986 | Nature1986，319，： | 1 |
| 11 | New evidence on international R&D spillovers, human capital and productivity in the OECD 显示文摘 | T Barrio - Castro E Lopez - Bazo G Serrano - Domingo | 2002 | Economics Letters2002，，77： | 1 |
| 12 | Molecular and meso-and macroscopic properties of hierarchical nanocrystalline ZSM-5 zeolite prepared by seed silanization显示文摘 | Serrano D P Aguado J Morales G | | 0，，04： | 1 |
| 13 | Influence of sex and terminal sire line on performance and carcass and meat quality of Iberian pigs reared under intensive production systems 显示文摘 | Serrano M P Valencia D G Nieto M | 2008 | Meat Science2008，，78： | 1 |
| 14 | Surgi- cal position, cause of extraeranial internal carotid artery dissection, presenting as pourfour du petit syndrome: ease report and literature re- view 显示文摘 | Villalba Martinez G Navalpotro Gomez I Serrano Perez L | 2015 | Turk Neurosurg2015，25，4： | 1 |
| 15 | A glimpse of the mechanisms of ion homeostasis during salt stress显示文摘 | Serrano R Mulet J M Rios G Marquez J A de Larrinoa I D Leube M P Mendizabal I Pascual - Ahuir A Proft M Ros R Montesions C | 1999 | Journal of Experimental Botany1999，50，： | 1 |
| 16 | Comparative biochemical and functional studies of family Ⅰ soluble inorganic pyrophosphatases from photosynthetic bacteria显示文摘 | Gómez-García M R Losada M Serrano A | | 0，，15： | 1 |
| 17 | Co-gasification of biomass wastes and coal-coke blends in an entrained flow gasifier:an experimental study显示文摘 | Hemandez J J Almansa G A Serrano C | | 0，，04： | 1 |
| 18 | Cooperative Optical Wireless Transmission for Improving Performance in Indoor Scenarios for Visible Light Communications 显示文摘 | GUZMAN B G SERRANO A L Jimenez V P G | 2015 | IEEE Transactions on Consumer Electronics2015，61，4： | 1 |
| 19 | Disparity for the minor histocompatibility antigen HA-1 is associated with an increased risk of acute graft-versus-host disease(GvHD)but it does not affect chronic GvHD incidence,disease-free survival or overall survival after allogeneic human leucocyte antigen-identical sibling donor transplantation显示文摘 | Arostegui JI Balas A Torres A Caballero D Carreras E Brunet S Jimenez A Mataix R Serrano D Vallejo C Sanz G Solano C Rodriguez-Luaces M Marin J Baro J Sanz C Roman J Gonzalez M Martorell J Sierra J Martin C de la Camara R Granena A | 2001 | Br J Haematol2001，114，4： | 1 |
| 20 | Frequency of cognitive impairment without dementia in patientswith stroke: a two-year follow-up study 显示文摘 | Serrano S Domingo J Rodriguez G E | 2007 | Stroke2007，38，1： | 1 |
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