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| 1 | Effect of contrast-enhanced ultrasound on differential diagnosis of intrahepatic cholangiocarcinoma and arterial phase enhanced hepatic inflammatory lesions显示文摘Objective: To investigate differential diagnosis between intrahepatic cholangiocarcinoma(ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound(CEUS).Methods: ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging features of conventional ultrasound and CEUS were analyzed. The parameters of time intensity curve(TIC), including the arrival time, peak intensity(PI) in the lesions, the starting time for washout, and the intensity difference at 3 min(ΔI_3) after contrast agent infection between the lesion and the liver parenchyma, were compared between ICC and hepatic inflammatory lesions.Results: Twenty-five ICC and fifteen inflammatory patients were included in this study. Seventeen ICC(68.0%)and two inflammatory cases(13.3%) showed bile duct dilatation on conventional ultrasound. Using CEUS, three ICC cases(12.0%) were misdiagnosed as inflammatory lesions and three inflammatory lesions(20.0%) as ICC; two ICC(8.0%) and one inflammatory case(6.7%) could not be made definite diagnosis. Washout started at 34.5±3.5 s and 61.5±12.9 s for ICC and inflammatory lesions respectively(P<0.001). The intensity difference between lesion and liver parenchyma at 3 min after contrast agent injection was 10.8±3.1 dB in ICC and 4.2±2.3 dB in inflammatory group(P<0.001). The sensitivity and specificity differentiating ICC and inflammatory lesions were76% and 87% if the cut-off value of the intensity difference was 7.7 d B.Conclusions: Combined with TIC analysis, and particularly with the characteristic of the early-starting and obvious washout in ICC, CEUS can be useful in differential diagnosis between hepatic inflammatory lesions and ICC. | Shanshan Yin Qiuli Cui Kun Yan Wei Yang Wei Wu Liping Bao Minhua Chen | 2017 | Chinese Journal of Cancer Research2017，29，3： | 13 |
| 2 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 3 | Gold immunochromatographic sensor for the rapid detection of twenty-six sulfonamides in foods显示文摘一个金 immunochromatographic 传感器(GICS ) 在蜂蜜样品为 26 硫安类药剂的快速的察觉被开发。传感器基于能认出所有 26 硫安类药剂的组特定的 monoclonal 抗体(mAb ) 。三 haptens (1 与 thiazole 包围的 hapten, 2 与苯包围的 hapten,和 3 与直碳锁住的 hapten ) 被用于抗原准备。与 hybridoma 技术,组特定的 mAb 与 50% 最大的禁止的集中被屏蔽(对 sulfathizole (STZ ) 和从 0.08 ~ 90.18 ng/mL 的另外的 25 类似物的 IC 50) 。单音分散金 nanoparticles 与 mAb 被结合开发侧面的 immunochromatographic 长带。0.1 g/mL 的标记的抗体集中和在测试线的 0.2 g/mL 的涂层抗原集中为长带准备被选择。在优化条件,为 STZ 的集中的察觉( vLOD )的视觉限制, sulfamethoxazole , sulfamethizole ,磺胺嘧啶, sulfamerazine , sulfadimethoxine , sulfamonomethoxine , sulfameter , sulfamethoxypyridazine ,和 sulfachloropyridazine 下面是 5 , 0.25 , 0.25 , 10 , 5 , 10 , 25 , 2.5 , 5 , 0.25 ,和 10 g/kg 分别地。在蜂蜜样品的扫描仪分析为 26 硫安类药剂的察觉揭示了好性能。商业蜂蜜样品与传感器被测试,积极结果与高效的液体层析被证实。建议脱衣传感器在爱人样品为硫安类药剂污染物质的快速、可靠的决心提供一个方便方法。 | Yanni Chen Liqiang Liu Liguang Xu Shanshan Song Hua Kuang Gang Cui Chuanlai Xu | 2017 | Nano Research2017，10，8： | 11 |
| 4 | Gold nanoparticle-based paper sensor for ultrasensitive and multiple detection of 32 (fluoro)quinolones by one monoclonal antibody显示文摘为快速、同时的察觉(fluoro ) quinolones,认出 32 的广泛地特定的 monoclonal 抗体(mAb )(fluoro ) quinolone 抗菌素作为 hapten 用 norfloxacin 衍生物和 sarfloxacin 衍生物的混合物被准备。基于黄金, nanoparticles (AuNPs ) 当时是的 immunochromatographic 脱衣与山羊反老鼠抗体和抗原(联合到 ovalbumin 的 sarfloxacin ) 集合了,过去常分别地形成 C 线和 T 线。这抗原与竞争(fluoro ) 在与 mAbs 孵化的一件样品的 quinolones 用 AuNPs 标记。长带能检测 32 ( fluoro ) quinolones 包括 oxolinic 酸, nalidixic 酸, miloxacin , pipemidic 酸, piromidic 酸, rosoxacin , cinoxacin , norfloxacin , pefloxacin , lomfloxacin , enofloxacin , fleroxacin , ciprofloxacin , enrofloxacin , dafloxacin , orbifloxacin , sparfloxacin , gemifloxacin , besifloxacin , balofloxacin , gatifloxacin ,在在 10 mi 以内的牛奶的 moxifloxacin , nadifloxacin , ofloxacin , marbofloxacin , flumequine , pazufloxacin , prulifloxacin , sarafloxacin , difloxacin , trovafloxacin ,和 tosufloxacin 从 1 ~ 100 ng/mL 和察觉的限制的长带范围的截止价值是 0.1-10 ng/mL。长带不包括四圜素, sulfamethazine,氨比西林,抗生素的一种,黄麴毒素 B1,或 gentamicin 与抗菌素做跨 react。简言之,这 immunochromatographic 脱衣是为主要屏蔽的一个很有用的工具(fluoro ) 在牛奶的 quinolones。 | Juan Peng Liqiang Liu Liguang Xu Shanshan Song Hua Kuang Gang Cui Chuanlai Xu | 2017 | Nano Research2017，10，1： | 9 |
| 5 | A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells显示文摘 | Yujia Mao Shanshan Yin Jianmin Zhang Yu Hu Bo Huang Lianxian Cui Ning Kang Wei He | 2016 | Cellular & Molecular Immunology2016，13，2： | 8 |
| 6 | Mathematical Model and Experiment Validation of Fluid Torque by Shear Stress under Influence of Fluid Temperature in Hydro-viscous Clutch显示文摘The current design of hydro-viscous clutch(HVC)in tracked vehicle fan transmission mainly focuses on high-speed and high power.However,the fluid torque under the influence of fluid temperature can not be predicted accurately by conventional mathematical model or experimental research.In order to validate the fluid torque of HVC by taking the viscosity-temperature characteristic of fluid into account,the test rig is designed.The outlet oil temperature is measured and fitted with different rotation speed,oil film thickness,oil flow rate,and inlet oil temperature.Meanwhile,the film torque can be obtained.Based on Navier-Stokes equations and the continuity equation,the mathematical model of fluid torque is proposed in cylindrical coordinate.Iterative method is employed to solve the equations.The radial and tangential speed distribution,radial pressure distribution and theoretical flow rate are determined and analyzed.The models of equivalent radius and fluid torque of friction pairs are introduced.The experimental and theoretical results indicate that tangential speed distribution is mainly determined by the relative rotating speed between the friction plate and the separator disc.However,the radial speed distribution and pressure distribution are dominated by pressure difference at the lower rotating speed.The oil film fills the clearance and the film torque increases with increasing rotating speed.However,when the speed reaches a certain value,the centrifugal force will play an important role on the fluid distribution.The pressure is negative at the outer radius when inlet flow rate is less than theoretical flow,so the film starts to shrink which decreases the film torque sharply.The theoretical fluid torque has good agreement with the experimental data.This research proposes a new fluid torque mathematical model which may predict the film torque under the influence of temperature more accurately. | CUI Hongwei YAO Shouwen YAN Qingdong FENG Shanshan LIU Qian | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 6 |
| 7 | Additivity of pore structural parameters of granular activated carbons derived from different coals and their blends显示文摘A series of granular activated carbons(GACs) were prepared by briquetting method from Chinese coals of different ranks and their blends,with coal pitch as the binder.Pore structural parameters including BET specific surface area(SBET),total pore volume(VT) and average pore diameter(da) were measured and calculated as well as process parameters such as yield of char(CY) and burn-off(B).The relationship between the pore structural parameters of the GAC from coal blend(BC-GAC) and the ones of the GACs from corresponding single coals(SC-GACs) was analyzed,in which an index,the relative error(d),was presented to define the bias between fitted values and experimental values of these parameters of the BC-GACs.The results show that the BC-GAC keeps qualitatively the pore structural features of the SC-GACs;as concerned as the quantitative relationship,the pore structural parameters of the BC-GAC from coal blend consisting of non-caking coals can be obtained by adding proportionally the pore structural parameters of the SC-GACs with d less than 10%.Meanwhile,for the BC-GAC from coal blend containing weak caking bituminous coal,the d increases up to 25% and the experimental pore size distribution differs greatly from the fitted one. | Yao Xin Xie Qiang Yang Chuan Zhang Bo Wan Chaoran Cui Shanshan | 2016 | International Journal of Mining Science and Technology2016，26，4： | 6 |
| 8 | Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration显示文摘Macrophages play an important role in material-related immune responses and bone formation,but the functionality of macrophage-derived extracellular vesicles(EVs)in material-mediated bone regeneration is still unclear.Here,we evaluated intracellular communication through small extracellular vesicles(sEVs)and its effects on endogenous bone regeneration mediated by biomimetic intrafibrillarly mineralized collagen(IMC).After implantation in the bone defect area,IMC generated more neobone and recruited more mesenchymal stem cells(MSCs)than did extrafibrillarly mineralized collagen(EMC).More CD63+CD90+and CD63+CD163+cells were detected in the defect area in the IMC group than in the EMC group.To determine the functional roles of sEVs,extracellular vesicles from macrophages cultured on different mineralized collagen were isolated,and they showed no morphological differences.However,macrophage-derived sEVs in the IMC group showed an enhanced Young’s modulus and exerted beneficial effects on the osteogenic differentiation of bone marrow MSCs by increasing the expression of the osteoblastic differentiation markers BMP2,BGLAP,COL1,and OSX and calcium nodule formation.Mechanistically,sEVs from IMC-treated macrophages facilitated MSC osteogenesis through the BMP2/Smad5 pathway,and blocking sEV secretion with GW4869 significantly impaired MSC proliferative,immunomodulative and osteogenic potential.Taken together,these findings show that macrophage-derived sEVs may serve as an emerging functional tool in biomaterial-mediated endogenous bone regeneration. | Anqi Liu Shanshan Jin Cuicui Fu Shengji Cui Ting Zhang Lisha Zhu Yu Wang Steve G.F.Shen Nan Jiang Yan Liu | 2020 | International Journal of Oral Science2020，12，4： | 5 |
| 9 | A fast and effective method to perform paternity testing for Wolong giant pandas显示文摘Captive populations provide a precious genetic resource for endangered animals and a source of individuals for reintroduction to depleted habitats. Therefore, accuracy in determining paternity is of vital importance for managing captive populations and in selecting representative individuals of known genetic characteristics for release. In this study, we established a fast and effective method to conduct paternity testing for captive giant pandas in the Wolong population. This technique uses two highly polymor phic microsatellites initially, subsequent use of five less polymorphic markers and then paternity exclusion testing carried out using the giant panda paternity exclusion program we have developed. Our results revealed that (1) both sets of markers success- fully identified the real fathers in 25 cases of paternity testing and (2) the success rate of paternity exclusion varied with the degree of polymorphism of the markers used. Subsequently, we conducted correlation analysis between the success rates of paterni- ty identification with these markers, parameters of genetic diversity and tests of neutrality. We found that the paternity exclusion power of microsatellites was significantly correlated with the number of alleles (Na), expected heterozygosity (HE) and observed homozygosity statistic (FO) (all P < 0.05). From this, we developed a new variable, Na?HE/FO, showing a highly significant positive correlation with the resolution power of microsatellites (P = 0.001). Moreover, the first two highly polymorphic loci gave a 100% success rate of excluding non-paternal males because they yielded higher values of Na?HE/FO than the other five less pol- ymorphic markers. Thus, the Na?HE/FO parameter appears suitable to serve as a criterion for selecting microsatellite markers, which could be used for high-resolution molecular techniques of paternity determination among a range of captive animals besides giant pandas. | LI DeSheng CUI HengMin WANG ChengDong LING ShanShan HUANG Zhi ZHANG HeMin | 2011 | Chinese Science Bulletin2011，56，24： | 4 |
| 10 | Biocompatibility of nano-hydroxyapatite/Mg-Zn-Ca alloy composite scaffolds to human umbilical cord mesenchymal stem cells from Wharton's jelly in vitro显示文摘Seeding cells and scaffolds play pivotal roles in bone tissue engineering and regenerative medicine.Wharton’s jelly-derived mesenchymal stem cells(WJCs)from human umbilical cord represent attractive and promising seeding cells in tissue regeneration and engineering for treatment applications.This study was carried out to explore the biocompatibility of scaffolds to seeding cells in vitro.Rod-like nano-hydroxyapatite(RN-HA)and flake-like micro-hydroxyapatite(FM-HA)coatings were prepared on Mg-Zn-Ca alloy substrates using micro-arc oxidation and electrochemical deposition.WJCs were utilized to investigate the cellular biocompatibility of Mg-Zn-Ca alloys after different surface modifications by observing the cell adhesion,morphology,proliferation,and osteoblastic differentiation.The in vitro results indicated that the RN-HA coating group was more suitable for cell proliferation and cell osteoblastic differentiation than the FM-HA group,demonstrating better biocompatibility.Our results suggested that the RN-HA coating on Mg-Zn-Ca alloy substrates might be of great potential in bone tissue engineering. | GUAN FangXia MA ShanShan SHI XinYi MA Xun CHI LianKai LIANG Shuo CUI YuanBo WANG ZhiBin YAO Ning GUAN ShaoKang YANG Bo | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 11 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 12 | An Optimization Approach for Stiffener Layout of Composite Stiffened Panels Based on Moving Morphable Components(MMCs)显示文摘An explicit topology optimization method for the stiffener layout of composite stiffened panels is proposed based on moving morphable components(MMCs).The skin and stiffeners are considered as panels with different bending stiffnesses,with the use of equivalent stiffness method.Then the location and geometric properties of composite stiffeners are determined by several MMCs to perform topology optimization,which can greatly simplify the finite element model.With the objective of maximizing structural stiffness,several typical cases with various loading and boundary conditions are selected as numerical examples to demonstrate the proposed method.The numerical examples illustrate that the proposed method can provide clear stiffener layout and explicit geometry information,which is not limited within the framework of parameter and size optimization.The mechanical properties of composite stiffened panels can be fully enhanced. | Zhi Sun Ronghua Cui Tianchen Cui Chang Liu Shanshan Shi Xu Guo | 2020 | Acta Mechanica Solida Sinica2020，33，5： | 2 |
| 13 | Graphene/RuO2 nanocrystal composites as sulfur host for lithium-sulfur batteries显示文摘An optimized graphene/RuO2/S composite is prepared by hydrothermal growth of RuO2 particles on graphene oxide sheets as the positive electrode for rechargeable lithium-sulfur batteries. The electrode with 6.1 wt% RuO2 nanocrystals and a high sulfur content of 79.0 wt% delivers an optimal electrochemical performance with high residual capacities of 508 mAh g-1 after 200 cycles and 389 m Ah g-1 after800 cycles at 1 C with a low capacity decay of 0.054%. The RuO2 nanocrystals promote the redox reaction kinetics and facilitate the transformation of sulfur chemistry, leading to large improvements in reversibility and rate capability of the composite electrode. The density functional theory calculations signify the formation of Li–O and Ru–S bonds through chemical interactions between RuO2 and Li polysulfides while the adsorption energies between graphene and polysulfide species are much higher in the presence of RuO2 than that of the neat graphene acting alone. These discoveries support the efficient entrapment of polysulfides by the composite electrode to the benefit of enhanced cyclic stability of the battery. | Jian-Qiu Huang Jiaqiang Huang Woon Gie Chong Jiang Cui Shanshan Yao Baoling Huang Jang-Kyo Kim | 2019 | Journal of Energy Chemistry2019，28，8： | 2 |
| 14 | Quantitative deconvolution of autocorrelations and cross correlations from two-dimensional lifetime decay maps in fluorescence lifetime correlation spectroscopy显示文摘Fluorescence correlation spectroscopy(FCS) is a widely used method for measuring molecular diffusion and chemical kinetics. However, when a mixture of fluorescent species is taken into account, the conventional FCS method has limitations in extracting autocorrelations for different species and cross correlations between different species. Recently developed fluorescence lifetime correlation spectroscopy(FLCS) based on time-tagged time-resolved(TTTR) photon recording, which can record the global and micro arrival time for each individual photon, has been used to discriminate different species according to fluorescence lifetime. Here, based on two-dimensional lifetime decay maps constructed from TTTR photon stream, we have developed a quantitative lifetime-deconvolution FCS model(LDFCS) to extract precise chemical rates for chemical conversions in multi-species systems. The key point of LDFCS model is separation of different species according to the global distribution of fluorescence lifetime and then deconvolution of autocorrelations and cross-correlations from the two-dimensional lifetime decay maps constructed by the micro arrival times of photon pairs at each delay time. | Shanshan Gao Menghua Cui Ruiru Li Ling Liang Ying Liu Liming Xie | 2017 | Science Bulletin2017，62，1： | 2 |
| 15 | Coil-levitated hybrid generator for mechanical energy harvesting and wireless temperature and vibration monitoring显示文摘The development of wireless monitoring is currently restricted by the short lifetime of batteries,requiring frequent replacement.Utilization of abundant mechanical energy from the surrounding environment has attracted increasing attention in real-time monitoring.Herein,a coil-levitated hybrid generator was developed for the efficient harvesting of mechanical energy from mechanical motion.The novel coil-levitated structure adapted to the metal and magnetic environment.The output currents were systematically analyzed at different operation modes based on the unique combination of triboelectrification,electromagnetic induction,and piezoelectric effect.Under the excitation of vibration frequency and amplitude of 8 Hz and 5 mm respectively,the as-constructed triboelectric nanogenerator delivered a peak power density of 11.40 W/m3 at 10 MΩ.Meanwhile,the middle electromagnetic part and bottom piezoelectric generator provided peak power densities of 6.97 and 79.93 W/m2 at 10000Ω,respectively.More importantly,the battery charging experiment was verified,in which a 30 mA h Li-ion battery can be charged from 2.57 to 3.27 V in about 90 min.In sum,a self-powered temperature and vibration monitoring system was successfully developed based on hybrid generator,promising for realizing wireless monitoring of mechanical equipment without any external power supply. | XUE XiaoBin ZHANG ZengXing WU Bin HE ShanShan WANG Qiang ZHANG WenJun BI RuiYu CUI Juan ZHENG YongQiu XUE ChenYang | 2021 | Science China(Technological Sciences)2021，64，6： | 2 |
| 16 | TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target显示文摘Pulmonary fibrosis(PF)is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic strategies.We recently reported that the protein kinase glycogen synthase kinase-3β(GSK-3β)interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta(C/EBPβ)in alveolar macrophages(AMs),resulting in a profibrotic phenotype of AMs and promoting the development of PF.Here,we showed that chronic lung injury upregulated the stress response protein tribbles homolog 3(TRIB3),which interacted with GSK-3βand stabilized GSK-3βfrom ubiquitination and degradation.Elevated GSK-3βexpression phosphorylated A20 to inhibit its ubiquitin-editing activity,causing the accumulation of C/EBPβand the production of several profibrotic factors in AMs and promoting PF development.Activated C/EBPβ,in turn,increased the transcription of TRIB3 and GSK-3β,thereby establishing a positive feedback loop in AMs.The knockdown of TRIB3 expression or the pharmacologic disruption of the TRIB3-GSK-3βinteraction was an effective PF treatment.Our study reveals an intact profibrotic axis of TRIB3-GSK-3β-A20-C/EBPβin AMs,which represents a target that may provide a promising treatment strategy for PF. | Shanshan Liu Xiaoxi Lv Xupeng Wei Chang Liu Qiao Li Jiali Min Fang Hua Xiaowei Zhang Ke Li Pingping Li Yang Xiao Zhuowei Hu Bing Cui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 2 |
| 17 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 18 | Hierarchically Porous NaCoPO4–Co3O4 Hollow Microspheres for Flexible Asymmetric Solid‐State Supercapacitors显示文摘 | Chengzhen Wei Cheng Cheng Binbin Zhou Xin Yuan Tingting Cui Shanshan Wang Mingbo Zheng Huan Pang | 2015 | Part. Part. Syst. Charact2015，，8： | 1 |
| 19 | Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats显示文摘 | Rutao Cui Jinchun He Baoen Wang Fukui Zhang Guangyong Chen Shanshan Yin Hong Shen | 2003 | Cancer Chemotherapy and Pharmacology2003，，1： | 1 |
| 20 | ESCRT-Ⅲ component OsSNF7.2 modulates leaf rolling by trafficking and endosomal degradation of auxin biosynthetic enzyme OsYUC8 in rice显示文摘The endosomal sorting complex required for transport(ESCRT)is highly conserved in eukaryotic cells and plays an essential role in the biogenesis of multivesicular bodies and cargo degradation to the plant vacuole or lysosomes.Although ESCRT components affect a variety of plant growth and development processes,their impact on leaf development is rarely reported.Here,we found that OsSNF7.2,an ESCRT-Ⅲ component,controls leaf rolling in rice(Oryza sativa).The Ossnf7.2 mutant rolled leaf 17(rl17)has adaxially rolled leaves due to the decreased number and size of the bulliform cells.OsSNF7.2is expressed ubiquitously in all tissues,and its protein is localized in the endosomal compartments.OsSNF7.2 homologs,including OsSNF7,OsSNF7.3,and OsSNF7.4,can physically interact with OsSNF7.2,but their single mutation did not result in leaf rolling.Other ESCRT complex subunits,namely OsVPS20,OsVPS24,and OsBRO1,also interact with OsSNF7.2.Further assays revealed that OsSNF7.2 interacts with OsYUC8 and aids its vacuolar degradation.Both Osyuc8and rl17 Osyuc8 showed rolled leaves,indicating that OsYUC8 and OsSNF7.2 function in the same pathway,conferring leaf development.This study reveals a new biological function for the ESCRT-Ⅲcomponents,and provides new insights into the molecular mechanisms underlying leaf rolling. | Liang Zhou Saihua Chen Maohong Cai Song Cui Yulong Ren Xinyue Zhang Tianzhen Liu Chunlei Zhou Xin Jin Limin Zhang Minxi Wu Shuyi Zhang Zhijun Cheng Xin Zhang Cailin Lei Qibing Lin Xiuping Guo Jie Wang Zhichao Zhao Ling Jiang Shanshan Zhu Jianmin Wan | 2023 | Journal of Integrative Plant Biology2023，65，6： | 1 |
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