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| 1 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 2 | Lovastatin and phenylacetate inhibit the induction ofnitric oxide synthase and eytokines in rat primary astrocytes, microglia and macrophages 显示文摘 | Pahan K Sheikh FG Namboodiri AM | 1997 | ] Clin Invest1997，100，11： | 1 |
| 3 | Tainted blood: Probing safety practices in the Danish blood system 显示文摘 | Deleuran I Sheikh ZA Hoeyer K | 2015 | Health (London)2015，19，5： | 1 |
| 4 | Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model显示文摘 | Wakabayashi K Nagai A Sheikh AM | 2010 | J Neurosci Res2010，88，5： | 1 |
| 5 | A Reliability Model For Fatigue Life Characterization显示文摘 | | 1995 | International Journal of Fatigue1995，17，2： | 1 |
| 6 | Papillary thyroid carcinoma: evidence for intracytoplasmic formation of precursor substance for calcification and its release from well preserved neoplastic cells 显示文摘 | DAS D K SHEIKH Z A GEORGE S S | 2008 | Diagn Cytopathol2008，36，： | 1 |
| 7 | A probabilistic approach to the maintenance of heat-transfer equipment subject to fouling显示文摘 | Zubair S M Sheikh A K Shaik M N | 1992 | Energy1992，17，8： | 1 |
| 8 | What Do We Know Abom Confinement in Reinforccd Concrele Columns (a Cril ical Review of Previous Work and Codc Provisions)显示文摘 | SAKAI K SHEIKH S A | 1989 | ACI Structural Journal1989，86，19： | 1 |
| 9 | Bernstein reliability model:derivation and estimation of parameters显示文摘 | Ahmad M Sheikh A K | 1984 | Reliability Engineering1984，，8： | 1 |
| 10 | Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, mieroglia, and macrophages显示文摘 | Pahan K Sheikh FG Namboodiri AM | 1997 | J Clin Invest1997，100，11： | 1 |
| 11 | A maintenance strategy for heat-transfer subject to fouling:a probabilistic approach显示文摘 | Zubair S M Sheikh A K Budair M O | 1997 | ASME J Heat Transfer1997，119，3： | 1 |
| 12 | No-reference quality assessment using natural secne statistics: JPEG2000 显示文摘 | Sheikh H R Bovik A C Cormack L K | 2005 | IEEE Trans Image Process2005，14，1： | 1 |
| 13 | Autonomic dysfunction in obstructive sleep apnea is associated with impaired glucose regulation显示文摘 | Peltier AC Consens FB Sheikh K | | 0，，： | 1 |
| 14 | Determination of op timum parameters using grey relational analysis for multi per- formance characteristics in CO2 laser joining of dissimilar materi- als显示文摘 | Tamrin K F Nukman Y Sheikh N A | 2014 | Optics and Lasers in Engineering2014，57，1： | 1 |
| 15 | Comparison of MRI alpha angle meas- urement planes in fersoroacetabular im- pingement显示文摘 | Rakhra K S Sheikh A M Allen D | 2009 | Clin Orthop Relat Res2009，467，3： | 1 |
| 16 | Chaparral-associated hepatotoxicity显示文摘 | Sheikh N K Philen R M Love L A | 1997 | Arch Intern Med1997，157，： | 1 |
| 17 | Statistical modeling of pitting corrosion and pipeline reliability显示文摘 | Sheikh A K Boah J K Hansen D A | 1990 | Corrosion1990，46，3： | 1 |
| 18 | Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia and macrophages 显示文摘 | Pahan K Sheikh FG Namboodiri AM | 1997 | J Clin Invest1997，100，： | 1 |
| 19 | Statistical modeling of pitting corrosion and pipeline reliability显示文摘 | Sheikh A K Boah J K Hansen D A | 1990 | Corrosion1990，46，3： | 1 |
| 20 | Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes显示文摘 | Pahan K Namboodiri A M Sheikh F G | 1997 | J Biol Chem1997，272，12： | 1 |
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