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| 1 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 2 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 3 | Recent advances and perspectives of nucleic acid detection for coronavirus显示文摘The recent pneumonia outbreak caused by a novel coronavirus(SARS-CoV-2)is posing a great threat to global public health.Therefore,rapid and accurate identification of pathogenic viruses plays a vital role in selecting appropriate treatments,saving people's lives and preventing epidemics.It is important to establish a quick standard diagnostic test for the detection of the infectious disease(COVID-19)to prevent subsequent secondary spread.Polymerase chain reaction(PCR)is regarded as a gold standard test for the molecular diagnosis of viral and bacterial infections with high sensitivity and specificity.Isothermal nucleic acid amplification is considered to be a highly promising candidate method due to its fundamental advantage in quick procedure time at constant temperature without thermocycler opera-tion.A variety of improved or new approaches also have been developed.This review summarizes the currently available detection methods for coronavirus nucleic acid.It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coro-navirus infection. | Minzhe Shen Ying Zhou Jiawei Ye Abdu Ahmed Abdullah AL-maskri Yu Kang Su Zeng Sheng Cai | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 27 |
| 4 | Effect of Substructure on Toughness of Lath Martensite/Bainite Mixed Structure in Low-Carbon Steels显示文摘The quantitative analysis of substructure in the martensite/bainite mixed structure, which is obtained from low-carbon NiCrMoV steels under different cooling conditions, was made by means of optical microscope (OM), scanning electron microscope (SEM), electron backscatter diffraction (EBSD), and transmission electron microscope (TEM), in order to research the effect on toughness. The test results indicate that the toughness of the steel is enhanced with the decrease in the packet and block size under the condition of the same prior austenite grain size mixed with different ratios of martensite and bainite while the lath width is about 0.38 μm. The calculation shows that both the packet and block boundaries have the same hindering effect on crack extension. Furthermore, the effect of the block width on impact energy is much larger than that of the packet. Therefore, the block can be used as microstructural substructure to affect the toughness in low-carbon martensite steels, suggesting that the block size is 'the effective grain size' for controlling toughness. | LUO Zhi-jun SHEN Jun-chang SU Hang DING Yue-hua YANG Cai-fu ZHU Xing | 2010 | Journal of Iron and Steel Research(International)2010，17，11： | 24 |
| 5 | NEW METHOD OF SIMULATING CONCENTRATED DRAIN HOLES IN SEEPAGE CONTROL ANALYSIS显示文摘In this paper, based upon the basic solution of sink, the approximate solution of single drain hole in finite elements is derived by use of the superposition principle. Then, the theoretical solution is extended to the case of some drain holes in one finite element, and the method is used in seepage control analysis with quick convergence and high accuracy. On the other hand, if the positions of the drain holes are changed, only some control factors of drain holes are changed, but the finite element grid need not to be reformed. Therefore, the method is more suitable in optimal research of seepage control. | Zhan Mei li, Su Bao yu , Liu Jun yong, Shen Zhen zhong College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing 210098, P.R.China (Received Aug.1, 1998) | 1999 | Journal of Hydrodynamics1999，11，3： | 22 |
| 6 | Optimization of regularization parameter of inversion in particle sizing using light extinction method显示文摘In particle sizing by light extinction method, the regularization parameter plays an important role in applying regularization to find the solutionto ill-posed inverse problems. We combine the generalized cross-validation (GCV) and L-curve criteria with the Twomey-NNLS algorithmin parameter optimization. Numerical simulation and experimental validation show that the resistance of the newly developed algorithms tomeasurement errors can be improved leading to stable inversion results for unimodal particle size distribution. | Mingxu Su Feng Xu Xiaoshu Cai Kuanfang Ren Jianqi Shen | 2007 | China Particuology2007，5，4： | 22 |
| 7 | Subcellular localization of the stripe disease-specific protein encoded by rice stripe virus (RSV) in its vector,the small brown planthopper,Laodel-phax striatellus显示文摘The stripe disease-specific protein (SP) encoded by the rice stripe virus (RSV) was successfully used as a localization signal of the virus in its vector, the small brown lanthopper, Laodelphax striatellus Fallen. Immunogold particles in large numbers were detected in various parts of the viruliferous females: the ovum, surface of chorion, the mid-gut lumen, and the columnar cells. Whereas there was noneof these particles in the non-viruliferous females and males, and testis of viruliferous males. Endosymbionts (mycetocytes) were abundant, harboring ovaries of both viruliferous and non-viruliferous females, but none in the testis of males. The results provided us with the direct proof that RSV is a ciruculative and propagative plant virus and it was transovarially transmitted alongside with endosymbionts of its vector. Therefore, we deem it a nice lead for future studies on the mechanism of RSV transmission and functioning of its viral proteins. | WU Aizhong ZHAO Yan QU Zhicai SHEN Daleng PAN Chongguang SU Deming | 2001 | Chinese Science Bulletin2001，46，21： | 23 |
| 8 | Isolation,characterization,and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province,China显示文摘Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients(2015–2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease(SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province. | Yanfang Zhang Shu Shen Junming Shi Zhengyuan Su Mingyue Li Wenjing Zhang Mengmeng Li Zhihong Hu Cheng Peng Xin Zheng Fei Deng | 2017 | Virologica Sinica2017，32，1： | 21 |
| 9 | Knockdown of survivin expression by siRNAs enhances chemosensitivity of prostate cancer cells and attenuates its tumorigenicity显示文摘Survivin, apoptosis 家庭蛋白质的禁止者的一个成员,为肿瘤房间生存能力在肿瘤房间和它的重要角色由于它的选择表示在癌症成为了一个吸引人的治疗学的目标。这里,我们在前列腺癌症房间显示出那基于向量的小介入 RNA (siRNAs ) silenced survivin 表情,导致显著地减少了房间增长并且提高了 apoptosis,并且增加了前列腺癌症房间(PC-3 ) 的敏感到导致 apoptosis 代理人, platinol。而且,有表示 siRNA 向量的 PC-3 房间 transfected 在 vivo 在裸体老鼠异种皮移植显示出更低的肿瘤形成。这些结果证明由 siRNA 的 survivin 表示的抑制稀释了前列腺癌症房间的恶意的显型,并且可以为雄激素无关的前列腺癌症的基因治疗提供一条新奇途径。 | Jianjun Shen Jiayun Liu Yin Long Yinye Miao Mingquan Su Qing Zhang Hua Han Xiaoke Hao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 19 |
| 10 | Manufacturing Technology and Application Trends of Titanium Clad Steel Plates显示文摘Some of the major manufacturing processes and corresponding mechanical properties of titanium clad steel plates were analyzed, and the consequences of research, manufacturing, and application of titanium clad steel plates in both markets of China and overseas were also summarized. As an economical and environmentally friendly technology, the roll bonding process is expected to become the next-generation mainstream process for the manufacturing of titanium clad steel plate. Some of the crucial and most important technical problems of this particular process, including vacuum sealing technology, surface treatment process technology, application of a transition layer, and rolling process, were discussed along with the advantageous mechanical properties and life-cycle economy of these plates processed by this technology. Finally, the market needs, application trends, and requirements of titanium clad steel plate were also considered from industries of petrochemical, shipbuilding, marine, and electric power. | Hang SU Xiao-bing LUO Feng CHAI Jun-chang SHEN Xin-jun SUN Feng LU | 2015 | Journal of Iron and Steel Research(International)2015，22，11： | 18 |
| 11 | Hyperbaric oxygen therapy improves cognitive functioning after brain injury显示文摘Hyperbaric oxygen therapy has been widely applied and recognized in the treatment of brain injury;however,the correlation between the protective effect of hyperbaric oxygen therapy and changes of metabolites in the brain remains unclear.To investigate the effect and potential mechanism of hyperbaric oxygen therapy on cognitive functioning in rats,we established traumatic brain injury models using Feeney’s free falling method.We treated rat models with hyperbaric oxygen therapy at 0.2 MPa for 60 minutes per day.The Morris water maze test for spatial navigation showed that the average escape latency was significantly prolonged and cognitive function decreased in rats with brain injury.After treatment with hyperbaric oxygen therapy for 1 and 2 weeks,the rats’spatial learning and memory abilities were improved.Hydrogen proton magnetic resonance spectroscopy analysis showed that the N-acetylaspartate/creatine ratio in the hippocampal CA3 region was significantly increased at 1 week,and the N-acetylaspartate/choline ratio was significantly increased at2 weeks after hyperbaric oxygen therapy.Nissl staining and immunohistochemical staining showed that the number of nerve cells and Nissl bodies in the hippocampal CA3 region was significantly increased,and glial fibrillary acidic protein positive cells were decreased after a 2-week hyperbaric oxygen therapy treatment.Our findings indicate that hyperbaric oxygen therapy significantly improves cognitive functioning in rats with traumatic brain injury,and the potential mechanism is mediated by metabolic changes and nerve cell restoration in the hippocampal CA3 region. | Su Liu Guangyu Shen Shukun Deng Xiubin Wang Qinfeng Wu Aisong Guo | 2013 | Neural Regeneration Research2013，8，35： | 16 |
| 12 | Object-oriented land cover classification using HJ-1 remote sensing imagery显示文摘The object-oriented information extraction technique was used to improve classification accuracy,and addressed the problem that HJ-1 CCD remote sensing images have only four spectral bands with moderate spatial resolution.We used two key techniques:the selection of optimum image segmentation scale and the development of an appropriate object-oriented information extraction strategy.With the principle of minimizing merge cost of merging neighboring pixels/objects,we used spatial autocorrelation index Moran's I and the variance index to select the optimum segmentation scale.The Nearest Neighborhood(NN) classifier based on sampling and a knowledge-based fuzzy classifier were used in the object-oriented information extraction strategy.In this classification step,feature optimization was used to improve information extraction accuracy using reduced data dimension.These two techniques were applied to land cover information extraction for Shanghai city using a HJ-1 CCD image.Results indicate that the information extraction accuracy of the object-oriented method was much higher than that of the pixel-based method. | SUN ZhongPing1,SHEN WenMing1,WEI Bin1,LIU XiaoMan1,SU Wei2,ZHANG Chao2 & YANG JianYu2 1 Satellite Environment Center,Ministry of Environmental Protection,Beijing 100094,China 2 College of Information and Electrical Engineering,China Agricultural University,Beijing 100083,China | 2010 | Science China Earth Sciences2010，53，S1： | 15 |
| 13 | OB glue paste technique for establishing nude mouse human gastric cancer orthotopic transplantation models显示文摘AIM: To establish nude mouse human gastric cancer orthotopic transplantation models using OB glue paste technique. METHODS: Using OB glue paste technique, orthtopic transplantation models were established by implanting SGC-7901 and MKN-45 human gastric cancer cell strains into the gastric wall of nude mice. Biological features, growth of the implanted tumors, the success rate of transplantation and the rate of auto-metastasis of the two models were observed. RESULTS: The success rates of orthotopic transplan- tation of the two models were 94.20% and 96%. The rates of hepatic metastasis, pulmonary metastasis, peritoneal metastasis, lymphocytic metastasis and splenic metastasis were 42.13% and 94.20%, 48.43% and 57.97%, 30.83% and 36.96%, 67.30% and 84.06%, and 59.75% and 10.53%, respectively. The occurrence of ascites was 47.80% and 36.96%. CONCLUSION: OB glue paste technique is easy to follow. The biological behaviors of the nude mouse human gastric cancer orthotopic transplantation models established with this technique are similar to the natural processes of growth and metastasis of human gastric cancer, and, therefore, can be used as an ideal model for experimental research of proliferative metastasis of tumors. | Jun Shi Pin-Kang Wei Shen Zhang Zhi-Feng Qin Jun Li Da-Zhi Sun Yan Xiao Zhi-Hong Yu Hui-Ming Lin Guo-Jing Zheng Xiao-Mei Su Ya-Lin Chen Yan-Fang Liu Ling Xu | 2008 | World Journal of Gastroenterology2008，14，30： | 15 |
| 14 | Numerical Simulation of a Planing Vessel at High Speed显示文摘计划容器处于民用、军事的状况广泛地被使用。由于他们的高速度,计划容器的运动是复杂的。以便预言计划容器的运动,分析以高速度计划容器的水动力学表演是重要的。计算液体动态方法(CFD ) 被建议了计算计划容器的水动力学性能。在很传统的 CFD 途径,然而,模型测试或实验公式被需要在计算前获得计划容器的跑的态度。这份报纸论述一个新 CFD 方法计算计划容器的水动力学力量。数字方法基于平均 Reynolds 的海军司烧(RANS ) 方程。液体(VOF ) 的体积方法和 six-degrees-of-freedom 方程被使用。一个有效过程被介绍在数字模拟解决数字分叉问题。与试验性的结果相比,数字模拟结果显示跑的态度和水动力学性能能以高速度被预言很好。 | Yumin Su Qingtong Chen Hailong Shen Wei Lu | 2012 | Journal of Marine Science and Application2012，11，2： | 15 |
| 15 | Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines显示文摘Aim:To investigate the antiproliferative activity and apoptosis-inducing effectsof bufalin on human osteosarcoma cell lines.Methods:U-2OS and U-2OS meth-otrexate (MTX) 300-resistant cell lines were treated with bufalin.Cell viability wasassessed using the MTT assay.Cell-cycle status,apoptosis-inducing effects,and the expression of apoptosis-related proteins were evaluated by flow cytometry,fluorescent staining,DNA fragmentation assays,and Western blotting.The ef-fect of bufalin on dihydrofolate reductase (DHFR) expression was studied by RT-PCR and Western blotting.Results:Bufalin inhibited cell growth in both U-2OSand U-2OS MTX300 cells.The induction of G_2/M cell-cycle arrest was also seenin the cells treated with bufalin.The induction of apoptosis by bufalin was con-firmed by increased expression of the tumor suppressor protein p53 and the in-creased ratio of the Bax/Bcl-2 proteins.Bufalin induced apoptosis to the sameextent in both cell lines without regard to DHFR levels in the cells.Conclusion:Bufalin inhibited the growth of and induced apoptosis in both MTX-sensitive andMTX-resistant human osteosarcoma U-2OS cells.The apoptosis-inducing effectof bufalin was not influenced by the presence of high levels of the DHFR protein. | Jun-qiang,YIN Jing-nan SHEN Wei-wei SU Jin WANG Gang HUANG Song JIN Qian-chen GUO Chang-ye ZOU Hao-miao LI Fo-bao LI | 2007 | Acta Pharmacologica Sinica2007，28，5： | 13 |
| 16 | Hemi-semi Laminectomy Approach for the Microsurgical Treatment of Spinal Schwannomas显示文摘Objective To evaluate the safety and efficiency of hemi-semi laminectomy approach for the microsurgical treatment of spinal schwannomas.Methods A total of 22 patients underwent hemi-semi laminectomy for the microsurgical removal of spinal schwannomas during a period of 2009 and 2011 in Affiliated Hospital of Nantong University.We retrospectively analyzed the clinical outcomes of these patients.Results Of them,5 cases were diagnosed with cervical schwannomas,9 with thoracic schwannomas,and 8 with lumbar schwannomas.All the tumors including two dumbbell schwannomas were totally removed without major complications.Postoperatively,all patients were followed up from 6 to 36 months.The symptoms and signs were obviously improved,and no tumor recurrence or spinal deformity occurred.Conclusion Hemi-semi laminectomy is a safe and effective method for resection of spinal schwannomas. | Xing Su Wei Shi Qing-feng Huang Jian-hong Shen Jian Chen | 2012 | Chinese Medical Sciences Journal2012，27，2： | 11 |
| 17 | Numerical simulation of hydrodynamic environment effects of the reclamation project of Nanhui tidal flat in Yangtze Estuary显示文摘The reclamation is the main method in the coast exploitation, and the assessment of the hydrodynamic environment effect of the reclamation project is important for project's site selection and environmental protection. With consideration of the baroclinic water, a 3?D numerical model MIKE3 is applied to simulate Yangtze Estuary's hydrodynamic environment to predict the impacts of the reclamation project of the Nanhui tidal flat. The simulated results of the model agree well with the field data of the tide level, the current speed, the current direction, the temperature, the salinity and the water quality, and it is indicated that after the reclamation project, the high tide level will be lower, while the low tide level will be higher in the South Branch in general. During the spring tide in the dry season, the peak velocity during the ebb tide in the North Channel will be reduced by 13%, while it will be increased by 21% in the South Channel in average. The salinity will be increased in the North Channel, while reduced in the South Passage, besides, the reclamation project will aggravate the saltwater intrusion of the North Branch. The value of N/P will be increased by about 4% in the whole South Branch except for the North Channel, leading to a slight aggravation of the phosphorus restriction effect in the Yangtze Estuary. | Di-fan Cao Yong-ming Shen Mei-rong Su Chun-xue Yu | 2019 | Journal of Hydrodynamics2019，31，3： | 11 |
| 18 | Numerical modeling of DPSK pressure signals and their transmission characteristics in mud channels显示文摘A numerical model and transmission characteristic analysis of DPSK(differential phase shift keying)pressure signals in mud channels is introduced.With the control logic analysis of the rotary valve mud telemetry,a logical control signal is built from a Gate function sequence according to the binary symbols of transmitted data and a phase-shift function is obtained by integrating the logical control signal. A mathematical model of the DPSK pressure signal is built based on principles of communications by modulating carrier phase with the phase-shift function and a numerical simulation of the pressure wave is implemented with the mathematical model by MATLAB programming.Considering drillpipe pressure and drilling fluid temperature profile along drillpipes,the drillpipe of a vertical well is divided into a number of sections.With water-based drilling fluids,the impacts of travel distance,carrier frequency,drillpipe size,and drilling fluids on the signal transmission were studied by signal transmission characteristic analysis for all the sections.Numerical calculation results indicate that the influences of the viscosity of drilling fluids and volume fraction of gas in drilling fluids on the DPSK signal transmission are more notable than the others and the signal will distort in waveform with differential attenuations of the signal frequent component. | Shen Yue Su Yinao Li Gensheng Li Lin Tian Shouceng | 2009 | Petroleum Science2009，6，3： | 11 |
| 19 | Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction显示文摘 | Kai Qu Nai-ying Shen Xin-sen Xu Hai-bo Su Ji-chao Wei Ming-hui Tai Fan-di Meng Lei Zhou Yue-lang Zhang Chang Liu | 2013 | Acta Pharmacologica Sinica2013，34，9： | 11 |
| 20 | Classification of Irreducible Weight Modules with a Finite-dimensional Weight Space over Twisted Heisenberg-Virasoro Algebra显示文摘We show that the support of an irreducible weight module over the twisted Heisenberg-Virasoro algebra,which has an infinite-dimensional weight space,coincides with the weight lattice andthat all nontrivial weight spaces of such a module are infinite dimensional.As a corollary,we obtainthat every irreducible weight module over the twisted Heisenberg-Virasoro algebra,having a nontrivialfinite-dimensional weight space,is a Harish-Chandra module(and hence is either an irreducible highestor lowest weight module or an irreducible module from the intermediate series). | Ran SHEN Yu Cai SU | 2007 | Acta Mathematica Sinica,English Series2007，23，1： | 11 |
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