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| 1 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 2 | Prognostic potential of an immune score based on the density of CD8+ T cells, CD20+ B cells, and CD33+/p-STAT1+ double-positive cells and HMGB1 expression within cancer nests in stage ⅢA gastric cancer patients显示文摘Objective: There is heterogeneity in the prognosis of gastric cancers staged according to the tumornodes-metastasis(TNM) system.This study evaluated the prognostic potential of an immune score system to supplement the TNM staging system.Methods: An immunohistochemical analysis was conducted to assess the density of T cells, B cells, and myeloid-derived suppressor cells(MDSCs) in cancer tissues from 100 stage ⅢA gastric cancer patients; the expression of the high-mobility group protein B1(HMGB1) was also evaluated in cancer cells.The relationship between the overall survival(OS), disease-free survival(DFS), and immunological parameters was analyzed.Results: An immune score system was compiled based on the prognostic role of the density of T cells, B cells, MDSCs, and the expression of HMGB1 in cancer tissues.The median 5-year survival of this group of patient was 32%.However, the 5-year survival rates of 80.0%, 51.7%, 0%, 5.8%, and 0% varied among the patients with an immune score of 4 to those with an immune score of 0 based on the immune score system, respectively.Similarly, differences in DFS rates were observed among the immune score subgroups.Conclusions: An immune score system could effectively identify the prognostic heterogeneity within stage ⅢA gastric cancer patients, implying that this immune score system may potentially supplement the TNM staging system, and help in identifying a more homogeneous group of patients who on the basis of prognosis can undergo adjuvant therapy. | Jun Dong Jiao Li Shiming Liu Xingyu Feng Shi Chen Zhiwei Zhou Yingbo Chen Xiaoshi Zhang | 2016 | Chinese Journal of Cancer Research2016，28，5： | 3 |
| 3 | Deep Learning in Sheet Metal Bending With a Novel Theory-Guided Deep Neural Network显示文摘Sheet metal forming technologies have been intensively studied for decades to meet the increasing demand for lightweight metal components.To surmount the springback occurring in sheet metal forming processes,numerous studies have been performed to develop compensation methods.However,for most existing methods,the development cycle is still considerably time-consumptive and demands high computational or capital cost.In this paper,a novel theory-guided regularization method for training of deep neural networks(DNNs),implanted in a learning system,is introduced to learn the intrinsic relationship between the workpiece shape after springback and the required process parameter,e.g.,loading stroke,in sheet metal bending processes.By directly bridging the workpiece shape to the process parameter,issues concerning springback in the process design would be circumvented.The novel regularization method utilizes the well-recognized theories in material mechanics,Swift’s law,by penalizing divergence from this law throughout the network training process.The regularization is implemented by a multi-task learning network architecture,with the learning of extra tasks regularized during training.The stress-strain curve describing the material properties and the prior knowledge used to guide learning are stored in the database and the knowledge base,respectively.One can obtain the predicted loading stroke for a new workpiece shape by importing the target geometry through the user interface.In this research,the neural models were found to outperform a traditional machine learning model,support vector regression model,in experiments with different amount of training data.Through a series of studies with varying conditions of training data structure and amount,workpiece material and applied bending processes,the theory-guided DNN has been shown to achieve superior generalization and learning consistency than the data-driven DNNs,especially when only scarce and scattered experiment data are available for training which is often the case in practice.The theory-guided DNN could also be applicable to other sheet metal forming processes.It provides an alternative method for compensating springback with significantly shorter development cycle and less capital cost and computational requirement than traditional compensation methods in sheet metal forming industry. | Shiming Liu Yifan Xia Zhusheng Shi Hui Yu Zhiqiang Li Jianguo Lin | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，3： | 2 |
| 4 | Hearing analysis in heterozygous and homozygous klotho gene deficient mice显示文摘Objective: To understand the crucial role of the klotho gene in hearing development in mouse models.Methods: PCR was used to identify CBA mice with different genotypes, i.e. WT, heterozygous(klotho +/-)or homozygous(klotho-/-). Mice phenotype and weight were recorded postnatal 25 days(P-25) and auditory brainstem responses(ABR) were used to determine auditory function at P-60.Results: klotho-/-mice tended to have smaller size, lighter weight and higher ABR thresholds at P-60,showing early onset age-related hearing loss(ARHL).Conclusion: Heterozygous and homozygous klotho deficient mice exhibit different degrees of hearing loss at young age, with homozygous mice(klotho-/-) showing more severe hearing loss. Our results indicate that persisted expression of klotho protein in the inner ear may potentially delay the onset of ARHL and play an important role in the protection of auditory function. | Na Yuan Shiwei Qiu Qian Wang Wei Zhuang Guoping Li Tiantian Sun Shiming Yang Yuehua Qiao Xi Shi | 2018 | Journal of Otology2018，13，4： | 2 |
| 5 | Enhanced weathering input from South Asia to the Indian Ocean since the late Eocene显示文摘nhanced silicate weathering induced by the uplift of the Himalayan-Tibetan Plateau(HTP)has been considered as the major cause of pCO_(2) decline and Cenozoic cooling.However,this hypothesis remains to be validated,largely due to the lack of a reliable reconstruction of the HTP weathering flux.Here,we present a 37-million-year record of the difference in the seawater radiogenic neodymium isotopic composition(△ε_(Nd))of Ocean Drilling Program(ODP)sites and Fe-Mn crusts between the northern and central Indian Ocean,which indicates the contribution of regional weathering input from the South Asian continent to the Indian Ocean.The results show a long-term increase in △ε_(Nd) and thus provide the first critical evidence of enhanced South Asian weathering input since the late Eocene.The evolution coincided well with major pulses of surface uplift in the HTP and global climatic transitions.Our foraminiferal eNd record suggests that tectonic uplift and silicate weathering in South Asia,especially in the Himalayas,might have played a significant role in the late Cenozoic cooling. | Zehua Song Shiming Wan Christophe Colin Christian France-Lanord Zhaojie Yu Arnaud Dapoigny Hualong Jin Mengjun Li Jin Zhang Debo Zhao Xuefa Shi Anchun Li | 2023 | Science Bulletin2023，，3： | 2 |
| 6 | Regioisomerism effect(RIE) on optimizing ultralong organic phosphorescence lifetimes显示文摘Organic phosphorescence materials demonstrate potential optoelectronic applications due to their remarkably ultralong organic phosphorescence(UOP)lifetime and abundant optical characteristics prior to the fluorescence materials.For a better insight into the intrinsic relationship among regioisomeric molecules,crystalline interactions,and phosphorescence properties,three crystalline dicarbazol-9-yl pyrazine-based regioisomers with para-,meta-and ortho-convergent substitutions(p-DCzP,m-DCzP,and o-DCzP)were designed and presented gradually increased UOP lifetimes prolonging from 63.14,127.93 to 350.46 ms,respectively,due to the regioisomerism effect(RIE)which would be an effective strategy for better understanding of structure-property of UOP materials. | Yanni Zhang Jianfeng Zhao Caixia Zhu Lifang Bian Huifang Shi Shiming Zhang Huili Ma Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 7 | THE COCHlEAR RIBBON SYNAPTIC RESPONSE TO AMINOGIYCOSIDE OTOTOXICITY IN C57BL/6J MICE显示文摘Objective To investigate the early change of cochlear ribbon synapses on inner hair cells in response to aminoglycoside ototoxicity. Methods C57BL/6J mice received intraperitoneal injection of gentamicin(100mg/kg/day), and the apical coil organ of Corti was examined on the 4th, 7th and 10 th day(n=10). Littermates without gentamicin treatment served as controls(n=10). RIBEYE on the presynaptic membrane and AMPA receptors on the postsynaptic membrane were labeled with CtBP2 or GluR2/3 respectively. Three dimension reconstruction was conducted using the 3DS MAX 8.0 software. Results There were no disruptions of outer or inner hair cells in all groups. However, the number of ribbon synapses on cochlear inner hair cells increased significantly within 7 days after gentamicin exposure(P<0.01), followed by a significant decrease after 7 days.Conclusion During the early stage of aminoglycoside ototoxicity, increased population of cochlear ribbon synapses may indicate a significant down-regulation of synaptic function. | LIU Ke ZHAO Ning SHI Chuang WU Nan LIU Huizhan ZHANG Yue YANG Weiyan YANG Shiming | 2014 | Journal of Otology2014，9，1： | 1 |
| 8 | Number analysis of steady current and temperature distributions and characteristics of transverse mode in VCSEL显示文摘 | Liu Shi'an Lin Shiming Kang Xuejun | 1999 | Chinese Journal of Semiconductor1999，20，11： | 1 |
| 9 | Allelopathy of Aspergillus japonicus on crops 显示文摘 | Zeng Rensen Luo shiming Shi Mubiao | 2001 | Agronomy Journal2001，93，1： | 1 |
| 10 | Shear bond mechanism of com- posite slabs - A universal FE approach, journal of construc- tional steel research显示文摘 | Shiming Chen Xiaoyu Shi | 2011 | 67(10) : 1475-14842011，67，10： | 1 |
| 11 | Physiological and biochemical mechanism of allelopathy of seealonic acid on higher plants 显示文摘 | Zeng Rensen Luo shiming Shi yuehong | 2001 | Agronomy Journal2001，93，1： | 1 |
| 12 | Genetic diversity of silver pomfret(Pampus argenteus) populations from the China Sea based on mitochondrial DNA control region sequences 显示文摘 | PENG Shiming SHI Zhaohong HOU Junli | 2009 | Biochemical Systematies and Ecology2009，25，： | 1 |
| 13 | EFFECTS OF MODERATE NOISE EXPOSURE ON HEARING FUNCTION IN C57BL/6J MICE显示文摘Objective To study characteristics of hearing loss after exposure to moderate noise exposure in C57BL/6J mice.Methods Male C57BL/6J mice with normal hearing at age of 5-6 weeks were chosen for this study.The mice were randomly selected to be studied immediately after exposure(Group P0),or 1 day(Group P1),3 days(Group P3),7 days(Group P7)or 14 days(P14)after exposure.Their before exposure condition served as the normal control.All mice were exposed to a broad-band white noise at 100 dB SPL for 2 hours,ABR thresholds were used to estimate hearing status at each time point.Results ABR threshold elevation was seen at every tested frequency at P0(P<0.01).Elevation at high-frequencies(16 kHz and 32 kHz)was greater than at lower frequencies(4 kHz and 8 kHz,P<0.05).From P1 to P14,ABR thresholds continuously improved,and there was no significant difference between P14 and before exposure(P>0.05).Conclusion There is a frequency specific response to 100 dB SPL broad-band white noise in C57BL/6J mice,with the high-frequency being more susceptible.Hearing loss induced by moderate noise exposure appears reversible in C57BL/6J mice. | SHI Chuang SHI Lei JIANG Xuejun YANG Shiming LIU Ke | 2014 | Journal of Otology2014，9，2： | 1 |
| 14 | Allelopathy of Aspergillus japonicus on crops 显示文摘 | ZENG RENSEN LUO SHIMING SHI MUBIAO | 2001 | Agronomy Journal2001，93，1： | 1 |
| 15 | Shear bond mechanism of composite slabs-A universal FE approach 显示文摘 | CHEN SHIMING SHI XIAOYU | 2011 | Journal of Constructional Steel Research2011，67，10： | 1 |
| 16 | Strength of composite slabs with end-anchorage studs显示文摘 | CHEN SHIMING SHI XIAOYU ZHOU YUEHUA | 2015 | Structures and Buildings2015，168，2： | 1 |
| 17 | Potential factors and mechanism of particulate matters explosive increase induced by free radicals oxidation显示文摘Atmospheric particulate pollution in China has attracted much public attention.Occasionally, the particle number concentration increases sharply in a short time period,which is defined as a 'particulate matter explosive increase'. Heavy particulate matter pollution not only reduces visibility but also has an adverse effect on human health. Hence,there is an urgent need to discover the causes of particulate matter explosive increase.During this campaign, the particle number concentration and free radicals were measured at a tall building on the campus of Lanzhou University of Technology. Additionally, we examined a series of chemicals to reproduce the observed particulate matter explosive increase in a smog chamber to determine its potential factors. Then, we analyzed the mechanism of particulate matter explosive increase in the presence of free radicals. We found that, among the potential inorganic and organic sources analyzed, a mixture of organic and SO_2 in the research region had a major effect on particulate matter explosive increase. Moreover, free radical oxidation has a large effect, especially in the formation of organic particulates. | Guoying Wang Shiming Jia Xiuli Niu Haoqi Tian Yanrong Liu Zhong Xie Chao Liu Yucan Dong Ying Su Jianglei Yu Gaofeng Shi Xuefu Chen Lan Li Peng Zhang | 2019 | Journal of Environmental Sciences2019，31，7： | 0 |
| 18 | Vestibular-evoked myogenic potentials in miniature pigs显示文摘Objective: To report detection of vestibular-evoked myogenic potentials(VEMPs) in the miniature pig.Methods: Potentials evoked by 1000 Hz tone bursts were recorded from neck extensor muscles and the masseter muscles in normal adult Bama miniature pigs anesthetized with 3% pentobarbital sodium and Carbachol II.Results: The latency of the first positive wave P from neck extensor muscles was 7.65 ± 0.64 ms, with an amplitude of 1.66 ± 0.34 uv and a rate of successful induction of 75% at 80 d B SPL. The latency of potentials evoked from the masseter muscles was 7.60 ± 0.78 ms, with an amplitude of 1.31 ± 0.28 uv and a rate successful induction of 66% at 80 d B SPL.Conclusion: The latencies and thresholds of VEMPs recorded from the neck extensor muscle and the masseter muscle appear to be comparable in normal adult Bama miniature pigs, although the amplitude recorded from the neck extensor muscle seems to be higher than that from the masseter muscle. However, because of their usually relatively superficial and easily accessible location, as well as their large volume and strong contractions, masseter muscles may be better target muscles for recording myogenic potentials. | Xi Shi Yan Zhang Ya Li Shiwei Qiu Shili Zhang Yaohan Li Na Yuan Yuehua Qiao Shiming Yang | 2016 | Journal of Otology2016，11，2： | 0 |
| 19 | Attenuation of ethylene signaling increases cotton resistance to a defoliating strain of Verticillium dahliae显示文摘The severity of Verticillium wilt on cotton caused by defoliating strains of Verticillium dahliae has gradually increased and threatens production worldwide. Identification of the molecular components of leaf defoliation may increase cotton tolerance to V. dahliae. Ethylene, a major player in plant physiological processes, is often associated with senescence and defoliation of plants. We investigated the cotton–V.dahliae interaction with a focus on the role of ethylene in defoliation and defense against V. dahliae.Cotton plants inoculated with V. dahliae isolate V991, a defoliating strain, accumulated more ethylene and showed increased disease symptoms than those inoculated with a non-defoliating strain. In cotton with a transiently silenced ethylene synthesis gene(GhACOs) and signaling gene(GhEINs) during cotton–V. dahliae interaction, ethylene produced was derived from cotton and more ethylene increased cotton susceptibility and defoliation rate. Overexpression of AtCTR1, a negative regulator in ethylene signaling, in cotton reduced sensitivity to ethylene and increased plant resistance to V. dahliae.Collectively, the results indicated precise regulation of ethylene synthesis or signaling pathways improve cotton resistant to Verticillium wilt. | Tianyi Wang Muhammad Shaban Junhui Shi Weiran Wang Shiming Liu Xinhui Nie Yu Yu Jie Kong Steven J.Klosterman Xianlong Zhang Alifu Aierxi Longfu Zhu | 2023 | The Crop Journal2023，11，1： | 0 |
| 20 | LDL receptor-related protein 1 (LRP1),a novel target for opening the blood-labyrinth barrier(BLB)显示文摘Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide.However,the presence of the blood-labyrinth barrier(BLB)on the surface of the inner ear capillaries greatly hinders the effectiveness of systemic drugs for prevention and intervention due to the low permeability,which restricts the entry of most drug compounds from the bloodstream into the inner ear tissue.Here,we report the finding of a novel receptor,low-density lipoprotein receptor-related protein 1(LRP1),that is expressed on the BLB,as a potential target for shuttling therapeutics across this barrier.As a proof-ofconcept,we developed an LRP1-binding peptide,IETP2,and covalently conjugated a series of model small-molecule compounds to it,including potential drugs and imaging agents.All compounds were successfully delivered into the inner ear and inner ear lymph,indicating that targeting the receptor LRP1 is a promising strategy to enhance the permeability of the BLB.The discovery of the receptor LRP1 will illuminate developing strategies for crossing the BLB and for improving systemic drug delivery for inner ear disorders. | Xi Shi Zihao Wang Wei Ren Long Chen Cong Xu Menghua Li Shiyong Fan Yuru Xu Mengbing Chen Fanjun Zheng Wenyuan Zhang Xinbo Zhou Yue Zhang Shiwei Qiu Liyuan Wu Peng Zhou Xinze Lv Tianyu Cui Yuehua Qiao Hui Zhao Weiwei Guo Wei Chen Song Li Wu Zhong Jian Lin Shiming Yang | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
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