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| 1 | Differences in lithospheric structures between two sides of Taihang Mountain obtained from the Zhucheng-Yichuan deep seismic sounding profile显示文摘A 2-D model of lithospheric velocity structures in the southern part of the North China Craton was obtained using data from the Zhucheng-Yichuan deep seismic sounding profile.Results show that there are great differences in lithospheric structures between two sides of Taihang Mountain.In the eastern region,the lithosphere is thinner,with a thickness of about 70-80 km,while in the western region,the thickness is 85-120 km.There is a jump of the lithospheric thickness across Taihang Mountain gravity anomaly belt with a magnitude of about 30 km.P wave velocities of the lithospheric mantle and lower crust are lower in the eastern region and higher in the western region.In the eastern region,there are low velocity bodies in the middle and lower crust,while none were found in the western region.These differences indicate that the Taihang Mountain gravity anomaly belt is a belt with a abrupt change of lithospheric thickness and lithological composition.According to the Pm waveform,it can be deduced that the Moho in the eastern region is not a sharp discontinuity,but a complex transitional zone.From a preliminary analysis,it is found that the geothermal mechanical-chemical erosion could be the main mechanism causing the thinning and destruction of the lithosphere beneath the eastern side of Taihang Mountain.In addition,subduction of the Pacific Plate is an important factor which changes the properties of the lithospheric mantle of the North China Craton. | LI SongLin LAI XiaoLing LIU BaoFeng WANG ZhiSuo HE JiaYong SUN Yi | 2011 | Science China Earth Sciences2011，54，6： | 27 |
| 2 | Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer显示文摘Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response. | Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan | 2021 | Cancer Biology & Medicine2021，18，3： | 11 |
| 3 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of intracerebral haemorrhage显示文摘Aim This evidence-based guideline aims to present current and comprehensive recommendations for the diagnosis and management of spontaneous intracerebral haemorrhage(ICH).Methods A formal literature search was conducted on MEDLINE(1 January 1990 to 30 June 2019).Data were synthesised using evidence tables.The members of the working group met by teleconference to update and formulate data-based recommendations.The recommendations are graded according to levels of evidence grading algorithm of the Chinese Stroke Association.The guideline draft has been reviewed by Chinese Stroke Association Stroke Council Guideline Writing Committee.Results Evidence-based guideline is proposed for the management of patients with ICH.The focus of the guideline is divided into the diagnosis and aetiology of ICH,management of ICH in emergency department,surgical treatment for removal of hematoma,management of complications and prevention of secondary ICH.Conclusions This guideline provides a framework for ICH management.Early active and reasonable treatment may improve the clinical outcome of patients. | Yong Cao Songlin Yu Qian Zhang Tao Yu Yanfang Liu Zhenghui Sun Meng Zhao Wen Wang Ji Zong Zhao | 2020 | Stroke & Vascular Neurology2020，5，4： | 8 |
| 4 | Zircon Hf Isotopes and Geochemistry of the Early Paleoproterozoic High-Sr Low-Y Quartz-Diorite in the Quanji Massif,NW China:Crustal Growth and Tectonic Implications显示文摘The metamorphosed Early Paleoproterozoic granitoids in the Quanji massif,Northwestern China provide constraints for relationship between the Tarim Craton and North China Craton.Among granitoids batholiths,rocks of the Mohe quartz-diorite show typically adakitic geochemical characteristics,with medium K2O/Na2O ratios(0.56–1.17)and high Sr(519–619 ppm)low Y(9.37–20.40 ppm)and Yb(0.97–1.77 ppm)concentrations.The rocks haveεNd(t)values between+2.4and+4.4 and depleted mantle Nd model ages of 2.43–2.59 Ga.The magmatic zircons have positiveεHf(t)values ranging from+0.40 to+7.60 and depleted mantle Hf model ages of 2.43–2.70 Ga,with major peaks at^2.54 and^2.65 Ga.The geochemical and Nd-Hf isotopic characteristics indicate that the Mohe quartz-dioritic rocks might be formed by partial melting of high-pressure metamorphosed juvenile crustal rocks in post-orogenic extensional regime in the Early Paleoproterozoic.It suggests that important crustal growth occurred in the Quanji massif and the Tarim Craton at^2.4 and 2.5–2.7 Ga.The Quanji massif and Tarim Craton might share a similar crustal evolution history with the North China Craton in the Neoarchean. | Songlin Gong Nengsong Chen Hongyan Geng Min Sun Lu Zhang Qinyan Wang | 2014 | Journal of Earth Science2014，25，1： | 8 |
| 5 | Local Gabor Dominant Direction Pattern for Face Recognition显示文摘We propose a novel face image representation – Local gabor dominant direction pattern(LGDDP)for face recognition. The face image is convolved with the Gabor filters, resulting in multiple response images of different orientations and scales. The response images' each pixel is encoded by the LGDDP descriptor from the pixel's dominant neighboring one or two pixels. The image formed by the LGDDP descriptor is partitioned into multiple regions and the histogram is extracted from each region. All the histograms are concatenated into the spatial histogram.The nearest neighbor classifier and the weighted intersection histogram similarity measure are used for face image classification. The advantage of the proposed LGDDP method lies in the high recognition rate performance and the low computational complexity. Extensive experiments are performed on FERET face image database and the experimental results verify the LGDDP's effectiveness by comparing LGDDP with other well-known published face recognition methods. | LIU Jun JING Xiaojun SUN Songlin LIAN Zifeng | 2015 | Chinese Journal of Electronics2015，24，2： | 8 |
| 6 | Numerical simulation of liquid falling film on horizontal circular tubes显示文摘这研究的目的是数字地在水平圆形的试管上调查掉落的电影的流动特征。数字模拟被执行用为有一个和二柱体的 2D 配置流畅。液体方法的卷被用来追踪液体掉落电影和煤气液体的接口的运动。热和转移系数上的流动特征的效果可能是显著的,尽管它在以前的研究被忽视了。最高的试管,底部试管上的一些特殊流动特征, intertube 流动模式和流动特征上的液体 feeder 高度的效果上的速度分发和电影厚度特征被学习了。我们的模拟显示那 1 )试管的上面、更低的部分的速度分布不严格地对称、不一致, 2 )电影厚度取决于流动率和尖分布, 3 )最高的试管的流动特征与底部试管的那些不同, 4 )三位校长和二个中间的转变模式被区分,并且 5 )液体喂高度戏掉落的形成上的一个重要角色电影。数字结果在与由 Nusselt 模型和报导结果的理论价值的一个好协议。 | Fengdan SUN Songlin XU Yongchuan GAO | 2012 | Frontiers of Chemical Science and Engineering2012，6，3： | 7 |
| 7 | Analysis of SSRs Derived from an EST Library of Half-Smooth Tongue Sole Cynoglossus semilaevis显示文摘A complementary DNA(cDNA) library was constructed from half-smooth tongue sole spleen. A long-read expressed sequence tag(EST) database was generated,containing 3100 cDNA clones,of which 220 clones were fully sequenced. A total of 1060 non-redundant simple sequence repeats(SSRs) were obtained from the cDNA library. An average of 5 kb sequence generates 1 SSR in the half-smooth tongue sole spleen cDNA library. The proportion of the SSR unit size was different in the cDNA library. The monomeric repeats(51.4%) are the most abundant class of SSR in the dataset. The dimeric,trimeric,tetrameric and hexameric re-peats are represented in decreasing proportions of 27.2%,16.0%,2.8% and 1.9%,respectively. The frequency of pentameric repeats was observed the least(only 0.7%) . Most of the monomeric and dimeric repeats are distributed in 3' and 5' un-translation region. If translation regions are considered merely,trimeric repeats are the highest,accounting for 57% of the total microsatellites. | LIU Yunguo BAO Baolong CHEN Songlin SUN Xiuqin | 2008 | Journal of Ocean University of China2008，7，3： | 4 |
| 8 | The molecular diversity of arbuscular mycorrhizal fungi in the arsenic mining impacted sites in Hunan Province of China显示文摘Arbuscular mycorrhizal fungi(AMF) can establish a mutualistic association with most terrestrial plants even in heavy metal contaminated environments. It has been documented that high concentrations of toxic metals, such as arsenic(As) in soil could adversely affect the diversity and function of AMF. However, there are still gaps in understanding the community composition of AMF under long-term As contaminations. In the present study, six sampling sites with different As concentrations were selected in the Realgar mining area in Hunan Province of China. The AMF biodiversity in the rhizosphere soils of the dominant plant species was investigated by sequencing the nuclear small subunit ribosomal RNA(SSU rR NA) gene fragments using 454-pyrosequencing technique. A total of 11 AMF genera were identified,namely Rhizophagus, Glomus, Funneliformis, Acaulospora, Diversispora, Claroideoglomus, Scutellopora,Gigaspora, Ambispora, Praglomus, and Archaeospora, among which Glomus, Rhizophagus, and Claroideoglomus clarodeum were detected in all sampling sites, and Glomus was the dominant AMF genus in the Realgar mining area. Redundancy analysis indicated that soil pH, total As and Cd concentrations were the main factors influencing AMF community structure. There was a negative correlation between the AMF species richness and the total As concentration in the soil,but no significant correlation between the Shannon–Wiener index of the AMF and plants. Our study showed that high As concentrations can exert a selective effect on the AMF populations. | Yuqing Sun Xin Zhang Zhaoxiang Wu Yajun Hu Songlin Wu Baodong Chen | 2016 | Journal of Environmental Sciences2016，28，1： | 4 |
| 9 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 10 | Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability显示文摘Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the'life science'tool box and represent promising avenue for biomedical monitoring. | Xiaoying Wu Jianyou Feng Jue Deng Zhichang Cui Liyuan Wang Songlin Xie Chuanrui Chen Chengqiang Tang Zhengqi Han Hongbo Yu Xuemei Sun Huisheng Peng | 2020 | Science China Chemistry2020，63，9： | 3 |
| 11 | Rhizophagus irregularis influences As and P uptake by alfafa and the neighboring non-host pepperweed growing in an As-contaminated soil显示文摘It was documented that arbuscular mycorrhiza fungi(AMF) play an important role in protecting host plants against arsenic(As) contamination. However, most terrestrial ecosystems contain a considerable number of nonmycorrhizal plants. So far little information is available for the interaction of such non-host plants with AMF under As contaminations. By using a dual compartment cultivation system with a plastic board or a nylon mesh separating roots of non-host pepperweed from roots of the AM-host alfafa plants, avoiding direct root competition, the two plant species were grown separately or partially separated(with rhizosphere effects) in the presence or absence of the AMF Rhizophagus irregularis in As-contaminated soil. The results indicated that mycorrhiza caused phosphorus(P) concentration decrease in the non-host pepperweed, but promoted the P concentration of the AM host alfafa. Mycorrhiza is potentially helpful for non-host pepperweed to adapt to As contamination by decreasing root As concentration and showing no suppressing effect on biomass production. The study provides further evidence for the protective effects of AMF on non-host plants against As contamination, and improved our understanding of the potential role of AMF for non-host plant adaptation to As contaminated soils. | Xin Zhang Baihui Ren Songlin Wu Yuqing Sun Baodong Chen Ruojuan Li | 2018 | Journal of Environmental Sciences2018，30，5： | 3 |
| 12 | Neutron activation analysis and Mossbauer spectroscopy research on coloring mechanism of Chinese Ru porcelain显示文摘The characteristic spectrum and its main wavelength of Ru porcelain glaze are measured by color difference instrument to determine the relations between glaze color and its main wavelength. The content of the 30 coloring elements in Ru porcelain is determined by neutron activation analysis (NAA), which showed that iron is the major coloring element. Mossbauer spectroscopy analysis shows that the iron element in the glaze exists in the form of structural iron (Fe2+, Fe3+). The quantitative relationship between the main wavelength of glaze in various colors and the relative content of structural iron (Fe2+/Fe3+) is determined. Thus the coloring mechanism of Ru porcelain is investigated entirely. | LI Rongwu YANG Lei LI Guoxia ZHAO Weijuan GAO Zhengyao XIE Jianzhong CHEN Jin ZHANG Bin SUN Xinmin FENG Songlin JIA Xiuqin HAN Song HUANG Zhongxiang | 2002 | Chinese Science Bulletin2002，47，14： | 2 |
| 13 | Determination of minimum overburden depth for underwater shield tunnel in sands:Comparison between circular and rectangular tunnels显示文摘With the development of global urbanization,the utilization of underground space is more critical and attractive for civil purposes.Various shapes of shield tunnels have been gradually proposed to cope with different geological conditions and service purposes of underground structures.Generally,reducing the burial depth of shield tunnel is conducive to construction and cost saving.However,extremely small overburden depth cannot provide sufficient uplift resistance to maintain the stability and serviceability of the tunnel.To this end,this paper firstly reviewed the status of deriving the minimum sand over-burden depth of circular shield tunnel using mechanical equilibrium(ME)method.It revealed that the estimated depth is rather conservative.Then,the uplift resistance mechanism of both circular and rectangular tunnels was deduced theoretically and verified with the model tests.The theoretical uplift resistance is consistent with the experimental values,indicating the feasibility of the proposed equations.Furthermore,the determination of the minimum soil overburden depth of rectangular shield tunnel under various working conditions was presented through integrated ME method,which can provide more reasonable estimations of suggested tunnel burial depth for practical construction.Additionally,optimizations were made for calculating the uplift resistance,and the soil thickness providing uplift resistance is suggested to be adjusted according to the testing results.The results can provide reference for the design and construction of various shapes of shield tunnels in urban underground space exploitation. | Weixin Sun Fucheng Han Hanlong Liu Wengang Zhang Yanmei Zhang Weijia Su Songlin Liu | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，7： | 2 |
| 14 | miR-21 inhibitor sensitizes human OSCC cells to cisplatin显示文摘 | Wang W Songlin P Sun Y | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 15 | A physics-informed data-driven model for landslide susceptibility assessment in the Three Gorges Reservoir area显示文摘Landslide susceptibility mapping is a crucial tool for analyzing geohazards in a region.Recent publications have popularized data-driven models,particularly machine learning-based methods,owing to their strong capability in dealing with complex nonlinear problems.However,a significant proportion of these models have neglected qualitative aspects during analysis,resulting in a lack of interpretability throughout the process and causing inaccuracies in the negative sample extraction.In this study,Scoops 3D was employed as a physics-informed tool to qualitatively assess slope stability in the study area(the Hubei Province section of the Three Gorges Reservoir Area).The non-landslide samples were extracted based on the calculated factor of safety(FS).Subsequently,the random forest algorithm was employed for data-driven landslide susceptibility analysis,with the area under the receiver operating characteristic curve(AUC)serving as the model evaluation index.Compared to the benchmark model(i.e.,the standard method of utilizing the pure random forest algorithm),the proposed method’s AUC value improved by 20.1%,validating the effectiveness of the dual-driven method(physics-informed data-driven). | Songlin Liu Luqi Wang Wengang Zhang Weixin Sun Jie Fu Ting Xiao Zhenwei Dai | 2023 | Geoscience Frontiers2023，14，5： | 1 |
| 16 | Application of genetic algorithm to sol- ving nonlinear model of aeroengine 显示文摘 | LI Songlin SUN Jianguo | 2003 | Chinese Journal of Aero- nautics2003，16，69： | 1 |
| 17 | miR-21 inhibitor sensitizes human OSCC cells to cisplatin显示文摘 | Wang W Songlin P Sun Y et at | 2012 | ]Viol Biol Rep2012，39，5： | 1 |
| 18 | Fault diagnosis of sensor by chaos particle swarm optimization algorithm and support vector machine显示文摘 | ZHAO Chenglin SUN Vuebin SUN Songlin | 2011 | Expert Systems with Applications2011，38，： | 1 |
| 19 | miR-21 inhibitor sensitizes human OSCC cells to cisplatin显示文摘 | Wei Wang Piao Songlin Yao Sun Bin Zhang Wang Jinhui | 2012 | Molecular Biology Reports2012，，5： | 1 |
| 20 | Fault diag- nosis of sensor by chaos particle swarm optimization algorithm and support vector machine 显示文摘 | Zhao Chenglin Sun Xuebin Sun Songlin | 2011 | Expert Systems with Appli- cations2011，38，8： | 1 |
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