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| 1 | Long-term outcome and prognostic factors of patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the long-term outcome and prognostic factors of patients with hilar cholangiocarinoma. METHODS: Ninety-six consecutive patients underwent treatment for malignant hilar bile duct tumors during 1995–2005. Of the 96 patients, 20 were initially treated with surgery (n = 2 R0 / n = 18 R1). In non-operated patients, data analysis was performed retrospectively. RESULTS: Among the 96 patients, 76 were treated with endoscopic transpapillary (ERC, n = 45) and/or percutaneous transhepatic biliary drainage (PTBD, n = 31). The mean survival time of these 76 patients undergoing palliative endoscopic and/or percutaneous drainage was 359 ± 296 d. The mean survival time of patients with initial bilirubin levels > 10 mg/dL was significantly lower (P < 0.001) than patients with bilirubin levels < 10 mg/dL. The mean survival time of patients with Bismuth stage Ⅱ (n = 8), Ⅲ (n = 28) and Ⅳ (n = 40) was 496 ± 300 d, 441 ± 385 d and 274 ± 218 d, respectively. Thus, patients with advanced Bismuth stage showed a reduced mean survival time, but the difference was not significant. The type of biliary drainage had no significant beneficial effect on the mean survival time (ERC vs PTBD, P = 0.806). CONCLUSION: Initial bilirubin level is a significant prognostic factor for survival of patients. In contrast, age, tumor stage according to the Bismuth-Corlette classification, and types of intervention are not significant prognostic parameters for survival. Palliative treatment with endoscopic or percutaneous biliary drainage is still suboptimal, new diagnostic and therapeutic tools need to be evaluated. | Andreas Weber Sonja Landrock Jochen Schneider Manfred Stangl Bruno Neu Peter Born Meinhard Classen Thomas Rsch Roland M Schmid Christian Prinz | 2007 | World Journal of Gastroenterology2007，13，9： | 23 |
| 2 | Pulmonary adrenomedullin Counteracts deterioration of coronary flow and myocardial performance evoked by pulmonary endothelins in experimental acute respiratory distress syndrome显示文摘 | STANGL K LAULE M RICHTER C | 2001 | Crit Care Med2001，29，5： | 2 |
| 3 | The role of tea and tea flavonoids in cardiovascular health显示文摘 | STANGL V LORENZ M STANGL K | 2006 | Mol Nutr Food Res2006，50，： | 1 |
| 4 | The role of tea and tea flavonoids in cardiovascular health 显示文摘 | Stangl V Lorenz M Stangl K | 2006 | Mol Nutr Food Res2006，50，2： | 1 |
| 5 | Rituximab and alemtuzumabinduce a nonclassic,caspase independent apoptic pathway in lymphoid cell lines and in chronic lymphocytic leukemiacells显示文摘 | Stangl maier M Reis S Hallek M | 2004 | Ann Hematol2004，83，10： | 1 |
| 6 | The role of tea and tea flavonoids in cardiovascular health 显示文摘 | STANGL V LORENZ M STANGL K | 2006 | Molecular Nutrient and Food Research2006，50，2： | 1 |
| 7 | An Alternative Approach for the Analysis of Nonlinear Vibrations显示文摘 | Stangl M Gerstmayr J lrschik H | 2008 | Journal of Sound and Vibration2008，310，3： | 1 |
| 8 | Conjugated linoleic acid effects on circulating hormones,metabolites and lipoproteins,and its proportion in fasting serum and erythrocyte membranes of swine 显示文摘 | Stangl G l Muner H Kirchgessner M | 1999 | Eur J Nutz1999，38，6： | 1 |
| 9 | The role of base excision repair genes OGG1, APN1 and APN2 in benzo pyrene-7, 8-dione induced p53 mutagenesis显示文摘 | Abedin Z Louis-Juste M Stangl M | 2013 | Mutat Res2013，750，12： | 1 |
| 10 | Different degrees of moderate iron deficiency modulate lipid metabolism of rats显示文摘 | Stangl GI Kirchgessner M | 1998 | Lipids1998，33，9： | 1 |
| 11 | The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets显示文摘 | STANGL V LORENZ M LUDWIG A | 2005 | J Nutr2005，135，2： | 1 |
| 12 | The role of tea and tea flavonoids in cardiovascular health显示文摘 | Lorenz M Stangl K | 2006 | Mol Nutr Food Res2006，50，2： | 1 |
| 13 | The flavonoid pMoretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets显示文摘 | Stangl V Lorenz M Ludwig A | 2005 | J Nutr2005，135，2： | 1 |
| 14 | Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway显示文摘 | Lorenz M Meiners S | 2004 | FASEBJ2004，18，2： | 1 |
| 15 | Elevated serum leptin in patients with coronary artery disease: no association with the Trp64Arg polymorphism of the beta3-adrenergic receptor显示文摘 | Stangl K Cascorbi I Laule M | 2000 | Int J Obes Relat Metab Disord2000，24，3： | 1 |
| 16 | Effects of alcohol on the heart 显示文摘 | Spies CD Sander M Stangl K | 2001 | Curt Opin Crit Care2001，7，5： | 1 |
| 17 | Superiority of Ibutilide (a newclass Ⅲ agent) over DL- sotalol in converting atrial flutter and atrial fibrillation 显示文摘 | VOS M A GOLITSYN S R STANGL K | 1998 | Heart1998，79，： | 1 |
| 18 | Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty显示文摘 | Muller MR Salat A Stangle P murabito M Pulaki S Boehm D | 1997 | Thromb Haemost1997，78，： | 1 |
| 19 | Sclerosing Encapsulating Peritonitis:MRI diagnosis显示文摘 | Huser N Stangl M Lutz J | 2006 | Eur Radiol2006，16，1： | 1 |
| 20 | Effects of alcohol on the heart显示文摘 | Spies CD Sander M Stangl K | 2001 | Curr Opin Crit Care2001，7，： | 1 |
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