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| 1 | 睾酮和良性前列腺增生症显示文摘由于医患双方对于男性迟发性腺功能减退症状的警觉,使得近期针对此类患者的睾酮治疗增多。但是考虑到睾酮治疗对前列腺的影响,尤其可能增加前列腺癌发病风险,促进了该方面的研究进展。出乎意料的是大量的回顾性或小样本随机研究提示睾酮治疗或可改善男性下尿路症状。虽然此改善的确切机理仍在争论中,但或许和代谢综合征密切相关。对于临床医生,这些研究的结果虽然让人期待,但是缺乏高等级证据支持。因此在诊断迟发性腺功能减退症或考虑睾酮治疗前,仍需对患者进行包括病史、体检和睾酮测量在内的全面临床检查。睾酮补充治疗可能导致尿潴留和加重下尿路症状,这些产品说明上标注的风险依然存在,应该在用药前向患者解释说明。 | Thomas R Jarvis Bilal Chughtai Steven A Kaplan | 2015 | Asian Journal of Andrology2015，17，2： | 7 |
| 2 | Gastric cancer in Alaska Native people: A cancer health disparity显示文摘AIM To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native(AN) people. METHODS A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty-two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White(NHW) and AN gastric cancer patient data between 2006-2014.RESULTS AN gastric cancer patients have a higher incidence rate, a poorer overall survival, and are diagnosed at a significantly younger age compared to NHW patients. AN patients differ from NHW patients in greater prevalence of non-cardia, diffuse subtype, and signet ring cell carcinomas. AN females were more likely to be diagnosed with later stage cancer, stage IV, compared to AN males. Diminished overall survival was observed among AN patients with increasing stage, O+ blood type, < 15 lymph nodes examined at resection, and no treatment. This study is the first report detailing the clinicopathologic features of gastric cancer in AN people with outcome data.CONCLUSION Our findings confirm the importance of early detection, treatment, and surgical resection for optimizing AN patient outcomes. Further research on early detection markers are warranted. | Holly A Martinson Nancy J Shelby Steven R Alberts Matthew J Olnes | 2018 | World Journal of Gastroenterology2018，24，25： | 6 |
| 3 | Shoot and root traits in drought tolerant maize(Zea mays L.) hybrids显示文摘This study aimed to investigate the differences in shoot and root traits, and water use and water use efficiency(WUE) in drought tolerant(DT) maize(Zea mays L.) hybrids under full and deficit irrigated conditions. A two-year greenhouse study was conducted with four hybrids(one conventional hybrid, 33D53AM, two commercial DT hybrids, P1151 AM, N75H, and an experimental hybrid, Exp HB) grown under two water regimes(I_(100) and I_(50), referring to 100 and 50% of evapotranspiration requirements). Under water stress, the hybids P1151 AM, N75, and Exp HB showed more drought tolerance and had either greater shoot dry weight or less dry weight reduction than the conventional hybrid(33 D53 AM). However, these three hybrids responded to water stress using different mechanisms. Compared with the conventional hybrid, the two commercial DT hybrids(P1151 AM and N75H) had a smaller leaf area, shoot dry weight, and root system per plant. As a result, these hybrids used less water but had a higher WUE compared with the conventional hybrid. In contrast, the experimental hybrid(ExpHB) produced more shoot biomass by silking stage at both irrigation levels than all other hybrids, but it had relatively lower WUE. The hybrids demonstrated different drought response mechanisms that may require different irrigation management strategies. More investigation and validation are needed under field conditions and in different soil types. | ZHAO Jin XUE Qing-wu Kirk E Jessup HOU Xiao-bo HAO Bao-zhen Thomas H Marek XU Wen-wei Steven R Evett Susan A O'Shaughnessy David K Brauer | 2018 | Journal of Integrative Agriculture2018，17，5： | 3 |
| 4 | Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality显示文摘 | Peter K Henke Susan Blackburn Mary C Proctor Jeri Stevens Debabrata Mukherjee Sanjay Rajagopalin Gilbert R Upchurch James C Stanley Kim A Eagle | 2004 | Journal of Vascular Surgery2004，，： | 2 |
| 5 | Phenotypic instability and rapid gene silencing in newly formed Arabidopsis alloteraploids显示文摘 | Comai L Tyagi A P Winter K Holmes-Davis R Reynolds S H Stevens Y Byers B | 2000 | Plant Cell2000，12，9： | 2 |
| 6 | frontier technology and absorptive capacity evidence from OECD manufacturing industries显示文摘 | KNELLER R STEVENS A | 2006 | Oxford Bulletin of Economics and Statistics2006，68，： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | A Composite core conductor for low sag at high temperatures显示文摘 | Ahmad A Eric J B Steven R N | 2005 | IEEE Transactions on Power Delivery2005，20，3： | 1 |
| 9 | Neurologi- cal complications of transplantation 显示文摘 | PUSTAVOITAU A BHARDWAJ A STEVENS R | 2011 | J Intensive Care Med2011，26，4： | 1 |
| 10 | UKPDS 59: hyperglycemia and other potentially modifiable risk factors for peripheral vascular dis- ease in type 2 diabetes显示文摘 | Adler AI Stevens R J Neil A | 2002 | Diabetes Care2002，25，： | 1 |
| 11 | Investigating Semantic Similarity Measures Across the Gene Ontology: The Relationship Between Sequence and Annotation 显示文摘 | Lord P W Stevens R D Brass A | 2003 | Bioinformatics2003，19，10： | 1 |
| 12 | Natural in situ relationships suggest coral reef calcium carbonate production will decline with ocean acidification显示文摘 | SHAW E C PHINN S R TILBROOK B STEVEN A | 2015 | Linmology and Oceanography2015，60，3： | 1 |
| 13 | Properties of skeletal muscle mitochondria isolated from subsarcolemmal and intermyofibrillar regions 显示文摘 | Cogswell A M Stevens R J Hood D A | 1993 | American Journal Physiology-Cell Physiology1993，264，： | 1 |
| 14 | Effect of bromide ion on formation of haas during chlorination 显示文摘 | Pourmoghaddas H Stevens A A Kinman R N | 1993 | J Am Water Works Ass1993，85，1： | 1 |
| 15 | Structural basis for selective inhibition of cyclooxygenase- 2 by anti-inflammatory agents 显示文摘 | KURUMBAIL R G STEVENS A M GIERSE J K | 1996 | Nature1996，384，： | 1 |
| 16 | Wolf and David Zilberman, Effect of Information Formats on Information Services: Analysis of Four Selected Agricultural Commodities in the USA显示文摘 | David R Just Steven A | 2006 | Agricultural Economics2006，，35： | 1 |
| 17 | Thermal degradation of the support in carbon-supported platinum electrocatalysts for PEM fuel cells 显示文摘 | STEVENS D A DAHN J R | 2005 | Carbon2005，43，： | 1 |
| 18 | Horizon- tal structures of velocity and temperature boundary layers in two-dimensional numerical turbulent Rayleigh-Benard convection显示文摘 | Zhou Q Sugiyama K Stevens R J A M | | 0，，： | 1 |
| 19 | MAP3Ks as central regulators of cell fate during development 显示文摘 | Evisabel A Craig Mark V Stevens Richard R Vaillancourt | 2008 | Developmental Dynamics2008，237，11： | 1 |
| 20 | Clinical guidelines Potential benefits, limitations, and harms of clinical guidelines显示文摘 | Steven H Woolf Grol R Hutchinson A | 1999 | BMJ1999，318，7182： | 1 |
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