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| 1 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 2 | The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges显示文摘The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory strategies.Synthetic and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric carbon.The participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard J.Roberts,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and adaptation.These include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed. | Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 2 |
| 3 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 4 | Progress towards dog-mediated rabies elimination in PR China:a scoping review显示文摘Background Rabies continues to be a serious threat to global public health endangering people’s health and public health safety.In the People’s Republic of China,multi-sectoral and comprehensive prevention and control strategies have aimed to extensively curb human rabies transmission.Here,we examine the current state of rabies infection in China,explore strategic interventions put in place in response to WHO’s ambition of“Zero rabies deaths by 2030”and critically assess the constraints and feasibility of dog-mediated rabies elimination in China.Methods This study analyzed and evaluated the process towards dog-mediated rabies elimination in China from five perspectives:namely,human,dog,policy,challenge,and prospects.Evidence-based data on progress of dog-mediated rabies elimination in China was derived from a number of sources;a literature search was undertaken using PubMed,Web of Science and CNKI databases,distribution data for human rabies cases as derived from the Data-center of the China Public Health Science and policy and document data were obtained from official websites of the relevant China ministries and commissions.Results The incidence of human rabies cases in China have shown a downward trend year-on-year since 2007.Implementation of a government-led,multi-sectoral“One Health”approach to combating rabies has driven down the total number of rabies deaths nationwide to around 200 in 2020.The number of provincial-level administrative divisions(PLADs)reporting human cases of rabies has also decreased to 21 in 2020,13 of which reported less than 10 cases.Furthermore,the number of outpatient visits seeking rabies post-exposure prophylaxis has risen dramatically over the past two decades,with demand being 15 times higher than it was initially.There remain however,significant gaps in rabies elimination outcomes across the different regions of China.To date the target of achieving a canine rabies vaccination rate of>75%has not been met.The challenges of rabies immunization of dogs and dog management in underdeveloped cities and rural areas need to be addressed together with more effective animal surveillance and rabies risk from and too wildlife and livestock.Conclusions The Chinese government-led,multi-sectoral“One Health”approach to combating rabies and has made significant progress over the past decade.Development and adoption of more cost-effective One Health strategies can achieve more nationally beneficial rabies elimination outcomes.The ambitious target of“Zero rabies deaths by 2030”can be met through establishment of long-lasting herd immunity in dogs by means of dog mass vaccination campaigns,dog population management,epidemiological surveillance and the application of large-scale oral rabies vaccine to eliminate rabies in wild animals coupled with deployment of cost-effective human post-exposure prophylaxis,and community education. | Tianren Shen Susan Christina Welburn Long Sun Guo-Jing Yang | 2023 | Infectious Diseases of Poverty2023，12，2： | 2 |
| 5 | A Resonant Accel- erometer with Two-Stage Micro-Leverage Mechanisms Fabricated by SOI-MEMS Technology 显示文摘 | Susan X P Su Henry S Yang Alice M Agogino | 2005 | IEEE Sensors Journal2005，5，6： | 1 |
| 6 | Influence of Technologic Advances on Outcomes in Patients With Unresectable, Locally Advanced Non–Small-Cell Lung Cancer Receiving Concomitant Chemoradiotherapy显示文摘 | Zhongxing X. Liao Ritsuko R. Komaki Howard D. Thames Helen H. Liu Susan L. Tucker Radhe Mohan Mary K. Martel Xiong Wei Kunyu Yang Edward S. Kim George Blumenschein Waun Ki Hong James D. Cox | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 7 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 8 | Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice显示文摘 | Kaizheng Gong Yiu-Fai Chen Peng Li Jason A. Lucas Fadi G. Hage Qinglin Yang Susan E. Nozell Suzanne Oparil Dongqi Xing | 2011 | Journal of Hypertension2011，，9： | 1 |
| 9 | TP53 hot spot mutations in ovarian cancer: Selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas显示文摘 | Brandon-Luke L. Seagle Chia-Ping Huang Yang Kevin H. Eng Monica Dandapani Oluwatosin Odunsi-Akanji Gary L. Goldberg Kunle Odunsi Susan Band Horwitz Shohreh Shahabi | 2015 | Gynecologic Oncology2015，，： | 1 |
| 10 | Epigenetics of Acute Lymphocytic Leukemia显示文摘 | Guillermo Garcia-Manero Hui Yang Shao-Qing Kuang Susan O’Brien Deborah Thomas Hagop Kantarjian | 2009 | Seminars in Hematology2009，，1： | 1 |
| 11 | Monocryl? suture, a new ultra-pliable absorbable monofilament suture显示文摘 | Rao S. Bezwada Dennis D. Jamiolkowski In-Young Lee Vishvaroop Agarwal Joseph Persivale Susan Trenka-Benthin Modesto Erneta Jogendra Suryadevara Alan Yang Sylvia Liu | 1995 | Biomaterials1995，，15： | 1 |
| 12 | Studies on mass summer mortality of cultured zhikong scallops(Chlamys farreri Jones et Preston)in China显示文摘 | Jie Xiaoa Susan E Fordb Hongsheng Yang | 2005 | Aquaculture2005，250，34： | 1 |
| 13 | Assessing risk to fresh water resources from long term CO 2 injection–laboratory and field studies显示文摘 | Rebecca C. Smyth Susan D. Hovorka Jiemin Lu Katherine D. Romanak Judson W. Partin Corrine Wong Changbing Yang | 2009 | Energy Procedia2009，，1： | 1 |
| 14 | Studies on mass summer mortality of cultured zhikong scallops(Chlamys Jhrreri Jones et Preston) in China 显示文摘 | Jie X Susan E F Yang H S | 2005 | Aquaculture2005，250，34： | 1 |
| 15 | Use of Abdominopelvic Computed Tomography in Emergency Departments and Rates of Urgent Diagnoses in Crohn’s Disease显示文摘 | Caroline Kerner Kathleen Carey Angela M. Mills Wei Yang Marie B. Synnestvedt Susan Hilton Mark G. Weiner James D. Lewis | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 16 | Effects of Delaying FK506 Administration on Neuroregeneration in a Rodent Model显示文摘 | Julia Sobol James Lowe III Robin Yang Subhro Sen Daniel Hunter Susan Mackinnon | 2003 | J reconstr Microsurg2003，，02： | 1 |
| 17 | The Product of the ABC Half-Transporter Gene ABCG2 (BCRP/MXR/ABCP) Is Expressed in the Plasma Membrane显示文摘 | Emmanuelle Rocchi Alexey Khodjakov Erin L. Volk Chih-Hsin Yang Thomas Litman Susan E. Bates Erasmus Schneider | 2000 | Biochemical and Biophysical Research Communications2000，，1： | 1 |
| 18 | G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates显示文摘 | Yang Wang Kirk J. Rowley Brian J. Booth Susan E. Sloan Donna M. Ambrosino Gregory J. Babcock | 2011 | Antiviral Research2011，，2： | 1 |
| 19 | Temperature- and pH-dependence of albite dissolution rate at acid pH显示文摘 | Yang Chen Susan L. Brantley | 1997 | Chemical Geology1997，，3： | 1 |
| 20 | Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients显示文摘 | John M Flack Suzanne Oparil J.Howard Pratt Barbara Roniker Susan Garthwaite Jay H Kleiman Yonghong Yang Scott L Krause Diane Workman Elijah Saunders | 2003 | Journal of the American College of Cardiology2003，，7： | 1 |
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