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| 1 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Salmonella typhi and gallbladder cancer:report from an endemic region显示文摘BACKGROUND:Evidence exists of a link between chronic infection by Salmonella typhi(S.typhi) and the development of gallbladder cancer(GBC),but several studies from endemic regions contradict its role in the etiopathogenesis of GBC.This study used various tools to assess the prevalence of S.typhi in patients with GBC and gallstone disease(GSD) in this region with a high incidence of GBC.METHODS:S.typhi was detected in tissue and bile by PCR and culture and in serum by the Widal test and indirect hemagglutination assay(IHA).PCR with two pairs of S.typhi specific primers(flagellin gene H1d and SOP E gene) could detect 0.6 ng of S.typhi DNA.Fifty-four patients with GBC(cases) were matched with 54 patients with GSD(controls).RESULTS:Of the 54 cases,24(44.44%) were positive on the Widal test and 12(22.22%) on IHA,compared to 13(24.07%) and 5(9.26%) respectively in the controls.Eighteen(33.33%) cases showed a positive result on PCR(tissue) and 2 on PCR(bile) vs.none in the controls.Bile culture revealed no Salmonella colonies in either cases or controls.Only 3 cases were positive for Salmonella on tissue culture compared to none in the controls.The sensitivity of PCR(tissue) relative to the Widal test,IHA,culture(bile and tissue) and PCR(bile) was 100% vs.66.67%,11.11%,and 11.11%,and the specificity was 83.33% vs.100%,100%,and 100%,respectively.CONCLUSIONS:S.typhi is significantly associated with GBC compared to GSD(33% vs.0%).PCR appears to be the most specific diagnostic tool,the gold standard for S.typhi in tissue samples. | Mallika Tewari Raghvendra R Mishra Hari S Shukla | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 5 |
| 3 | Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar:a novel modification to achieve early urinary continence in men undergoing robotic prostatectomy显示文摘 | Tewari AK Bigelow K Rao S | 2007 | Urology2007，，04： | 2 |
| 4 | Effects of process parameters on melt-spun Ag-Cu显示文摘 | THOMA D J GLASGOW T K TEWARI S N | 1988 | J Mater Sci1988，98，： | 1 |
| 5 | Sprayed ZnO thin films for ethanol sensors显示文摘 | Sahay P P Tewari S | 2005 | Materials Science2005，40，18： | 1 |
| 6 | Necrotizing stomatitis : a pos- sible periodontal manifestation of deferiprone-induced agranuloey- tosis显示文摘 | Tewari S Tewarl S Sharma RK | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，108，4： | 1 |
| 7 | Structure of the NS1 protein N-terminal origin recognition/nickase domain from the emerging human bocavirus显示文摘 | Tewary S K ghao H Shen W | 2013 | J Virol2013，87，11： | 1 |
| 8 | Microbial alkaline pectinases and their industrial applications:a review显示文摘 | Hoondal G S Tiwari R P Tewari R | 2002 | Applied Microbiology and Biotechnology2002，59，45： | 1 |
| 9 | Primary congenital anomalies of the corcoary arteries: a coronary arteriographic study 显示文摘 | Garg N Tewari S Kapoor A | 2000 | Int J Cardiol2000，74，1： | 1 |
| 10 | Variations in the shape of the superior orbital fissure显示文摘 | Sharma P K Malhotra V K Tewari S P | 1988 | Anat Anz1988，165，： | 1 |
| 11 | Avaluation of caldium hydroxide and Zinc oxide eugenol as root canal filling materials in primary teeth显示文摘 | MANI S H CHAWLA H S TEWARI A | 2000 | J Dent Child2000，67，2： | 1 |
| 12 | Mater Sci Eng A显示文摘 | Tiwari R Tewari S N Asthana R Garg A | 1995 | 192:3561995，192，： | 1 |
| 13 | High pressure processing offoods: an overview 显示文摘 | Tewari G Jayas D S Holley R A | 1999 | Sciences Des Aliments?1999，19，6： | 1 |
| 14 | Identification of bacteria recovered from animals using the 16S ribosomal RNA gene with pyrosequencing and Sanger sequencing 显示文摘 | Tewari D Cieply S Livengoed J | 2011 | J Vet Diagn Invest2011，23，6： | 1 |
| 15 | Isoconversional kinetic analysis of decomposition of nitroimidazoles: Friedman method vs Flynn-Wall-Ozawa method 显示文摘 | VENKATESH M RAVI P TEWARI S P | 2013 | Journal of the Physical Chemistry A2013，117，10： | 1 |
| 16 | Determination of benzene and total aromatics in commercial gasolines using packed column GC and NMR techniques显示文摘 | Singh A P Mukherji S Tewari A K | 2003 | Fuel2003，82，1： | 1 |
| 17 | Primary congenital anomalies of the coronary arteries: a coronary arteriographic study显示文摘 | Garg N Tewari S Kapoor A | 2000 | Int Cardiol2000，74，1： | 1 |
| 18 | A statistical model for wind power forecast error and its application to the estimation of penalties in liberalized markets 显示文摘 | TEWARI S GEYER C J MOHAN N | 2011 | IEEE Trans on Power Systems2011，26，4： | 1 |
| 19 | Mater Sci Eng A显示文摘 | Asthana R Tiwari R Tewari S N | 2002 | 336:992002，336，： | 1 |
| 20 | Effects of heat-treatment on the ex-tent of chromium depletion and caustic corrosion resistance of alloy690显示文摘 | Dutta R S Tewari R De P K | | 0，，02： | 1 |
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