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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients显示文摘 | MA Y Q THOMAS G N CRITCHLEY J A | 2003 | Metabolism2003，52，3： | 2 |
| 4 | Cure characteristics and physic mechanical properties of calcium carbonate reinforcement rubber composites 显示文摘 | Aprem A S lose S Thomas S Barkoula N M and Kocsis J K | 2003 | Eur Polymer2003，3969，： | 1 |
| 5 | Carbon and nitrogen dynamics in ageing earthworm casts in grasslands of the eastern plains of Colombia 显示文摘 | DECAENS T RANGEL A F ASAKAWA N THOMAS R J | 1999 | Biology and Fertility of Soils1999，30，1： | 1 |
| 6 | Effects of phosphate con- centration on cell division rates and yield of a tropical oceanic diatom 显示文摘 | Thomas W H Dodson A N | 1968 | The Biological Bulletin1968，134，1： | 1 |
| 7 | Effect of cross linking on the physicochemical properties of Cola starch显示文摘 | OMOJOLA M O MANU N THOMAS S A | 2012 | African Journal of Food Science2012，6，4： | 1 |
| 8 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 9 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 10 | Synthetic strategies to prepare 2-alkyl,2-aryland 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines显示文摘 | Christian A G N Montalbetti Thomas S C | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 11 | Photocatalytic Generation of Hydrogen from Methanol显示文摘 | Zabidi N A Mohd Thomas T F | 1998 | J Phys Sci1998，9，： | 1 |
| 12 | First measurements with the physikalisches institut radiometric experiment (PHIRE)显示文摘 | Gunderson K Thomas N Whitby J A | 2006 | Planetary and Space Science2006，54，11： | 1 |
| 13 | Changes in cholesterol ac- cumulation and steroid excretion in response to cellulose, alfalfa or oats in cholesterol -fed rats 显示文摘 | Kelley M J Thomas J N Story J A | 1992 | Nutrition research1992，12，4： | 1 |
| 14 | Ganesh, Modelling and Assessment of Critical Risks in BOT Road Projects 显示文摘 | Thomas A V Satyanarayana N Kalidindi L S | 2006 | Construction Management and Economics2006，24，4： | 1 |
| 15 | WinBUGSA bayesian modeling framework: concepts, structure and extensibility 显示文摘 | LUNN D J THOMAS A BEST N | 2000 | Statistics and Computing2000，10，4： | 1 |
| 16 | Clinical value of polysomnography显示文摘 | Douglas N J Thomas S Jan M A | 1992 | Lancet1992，339，8789： | 1 |
| 17 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 18 | Materials engi?neering for immunomodulation显示文摘 | HUBBELLJ A THOMAS S N SWARTZ M A | 2009 | Nature2009，462，44： | 1 |
| 19 | Low-temperature property and engine performance evaluation of ethyl and isopropyl esters of tallow and grease显示文摘 | Wu Wen-Hsin Foglia Thomas A Marmer William N | 1998 | Journal of the American Oil Chemists'' Society1998，75，12： | 1 |
| 20 | Fixation of the graft in reconstruction of the anterior cruciate ligament 显示文摘 | Harvey A Thomas N P Amis A A | 2005 | J Bone Joint Surg Br2005，87，： | 1 |
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