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| 1 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level显示文摘Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical couplings.Due to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte coculture.In conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell junctions.Consequently,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur randomly.Thus,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological processes.In this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic differentiation.Here,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions. | Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 4 | Synthesis, characterization and catalytic activity of ZSM-5 zeolites having variable silicon-to-aluminum ratios显示文摘 | Ali M A Brisdon B Thomas W J | 2003 | Applied Catalysis A: General2003，252，： | 1 |
| 5 | Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein显示文摘 | THOMAS J P KALYANARAMAN B GIROTTI A W | 1994 | Arch Biochem Biophys1994，315，2： | 1 |
| 6 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 7 | Measuring Values of Extra market Goods: Are Indirect Measures Biased? 显示文摘 | Richard C B Thomas A H | 1979 | American Journal of Agricultural Economics1979，61，5： | 1 |
| 8 | The structures of tetraaqua ( uracil - 6 - carboxylate) zinc (Ⅱ) monohydrate (A) and tetraaqua ( uracil - 6 - carboxylato) nickel(II) monohydrate (B) 显示文摘 | Karipidas A Thomas B | 1986 | Acta Cryst C1986，，42： | 1 |
| 9 | Model of inclusion removal during RH degassing of steel显示文摘 | Miki Y Thomas B G Denissov A | 1997 | Iron Steelmaker1997，24，8： | 1 |
| 10 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 11 | Perceived stress, intemal resources,and social support as determinants of mental health among young adults显示文摘 | Patrick A B Chamot E Thomas V P | 2004 | Quality Life Res2004，13，6： | 1 |
| 12 | Plasma norepinephrine in congestive heart failre显示文摘 | Thomas J A Marks B H | 1978 | Am J Cardial1978，41，2： | 1 |
| 13 | Application of heat treatment to enhance permeability in tight gas reservoirs显示文摘 | Jamaluddin A K M Bennion D B Thomas F B | 2000 | JCPT2000，39，11： | 1 |
| 14 | Infectious bursal disease virus capsid protein VP3 interacts with VP1, the RNA-dependent RNA polymerase, and with viral double-stranded RNA显示文摘 | TACKEN M G PEETER B P THOMAS A A | 2002 | J Virol2002，77，11： | 1 |
| 15 | Does leadership make a difference to organizational performance显示文摘 | Thomas A B | 1988 | Administrative Science Qua- rterly1988，33，3： | 1 |
| 16 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 17 | Modeling chloride diffu- sion in concrete:effect of fly ash and slag显示文摘 | THOMAS M D A BAMFORTH P B | 1999 | Cement and Con- crete Research1999，29，4： | 1 |
| 18 | Assessment of chaos-based FM signals for range-Doppler imaging 显示文摘 | FLORES B C SOLIS E A THOMAS G | 2003 | IEEE Proceedings-Radar Sonar and Navigation2003，150，4： | 1 |
| 19 | Antibody dependent enhancement and vaccine development 显示文摘 | Thomas S Redfern J B Lidbury B A Mahalingam S | 2006 | Expert Rev Vaccines2006，5，： | 1 |
| 20 | Modeling chloride diffusion in concrete effect of fly ash and slag 显示文摘 | Thomas M D A and Bamforth P B | 1999 | Cement and Concrete Research1999，，29： | 1 |
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