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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Lymph node imaging in initial staging of prostate cancer:An overview and update显示文摘Accurate nodal staging at the time of diagnosis of prostate cancer is crucial in determining a treatment plan for the patient.Pelvic lymph node dissection is the most reliable method,but is less than perfect and has increased morbidity.Cross sectional imaging with computed tomography(CT) and magnetic resonance imaging(MRI) are non-invasive tools that rely on morphologic characteristics such as shape and size of the lymph nodes.However,lymph nodes harboring metastatic disease may be normal sized and non-metastatic lymph nodes may be enlarged due to reactive hyperplasia.The optimal strategy for preoperative staging remains a topic of ongoing research.Advanced imaging techniques to assess lymph nodes in the setting of prostate cancer utilizing novel MRI contrast agents as well as positron emission tomography(PET) tracers have been developed and continue to be studied.Magnetic resonance lymphography utilizing ultra-small super paramagnetic iron oxide has shown promising results in detection of metastatic lymph nodes.Combining MRL with diffusion-weighted imaging may also improve accuracy.Considerable efforts are being made to develop effective PET radiotracers that are performed using hybrid-imaging systems that combine PET with CT or MRI.PET tracers that will be reviewed in this article include [^(18)F]fluoro-D-glucose,sodium [^(18)F]fluoride,[^(18)F]choline,[^(11)C]choline,prostate specific membrane antigen binding ligands,[^(11)C]acetate,[^(18)F]fluciclovine,gastrin releasing peptide receptor ligands,and androgen binding receptors.This article will review these advanced imaging modalities and ability to detect prostate cancer metastasis to lymph nodes.While more research isneeded,these novel techniques to image lymph nodes in the setting of prostate cancer show a promising future in improving initial lymph node staging. | Jessica G Zarzour Sam Galgano Jonathan McConathy John V Thomas Soroush Rais-Bahrami | 2017 | World Journal of Radiology2017，9，10： | 5 |
| 3 | Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families显示文摘AIM: To study the genotype phenotype correlation in Wilson's disease (WD) patients within families. METHODS: We report four unrelated families from South India with nine members affected with WD. Phenotype was classified as per international consensus phenotypic classifi cation of WD. DNA was extracted from peripheral blood and 21 exons of ATP7B gene and flanking introns were amplified by polymerase chain reaction (PCR). The PCR products were screened for mutations and the aberrant products noted on screening were sequenced. RESULTS: Four separate ATP7B mutations were found in the four families. ATP7B mutations were identical amongst affected members within each family. Three families had homozygous mutations of ATP7B gene while one family had compound heterozygous mutation, of which only one mutation was identifi ed. We noted concordance between ATP7B gene mutation and Wilson's disease phenotype amongst members within each family. The age of onset of symptoms or of detection of asymptomatic disease, baseline serum ceruloplasmin and baseline urinary copper levels were also similar in affected members of each family. Minor differences in phenotype and baseline serum ceruloplasmin level were noted in one family.CONCLUSION: We report concordance between ATP7B mutation and WD phenotype within each family with > 1 member affected with WD. Homozygous ATP7B mutation was present in 3 of the 4 families studied. Our report supports allelic dominance as a determinant of WD phenotype. However, in one family with compound heterozygous mutation, there was a similar WD phenotype which suggests that there may be other factors determining the phenotype. | S Santhosh RV Shaji CE Eapen V Jayanthi S Malathi P Finny N Thomas M Chandy G Kurian GM Chandy | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 4 | Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives显示文摘The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor receptor(EGFR)signaling has improved clinical outcome of patients withmetastatic colorectal cancer(mCRC).In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC.The effects of available treatment strategies for mCRC are often temporary,with resistance and disease progression developing in most patients.Thus,new treatment strategies are urgently needed.Some GI peptides including gastrin and gastrin releasing peptide,certain growth factors such as insulin-like growth factor-ⅠandⅡand neuropeptides such as growth hormone releasing hormone(GHRH)are implicated in the growth of CRC.Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide,GHRH,and with cytotoxic peptides that can be targeted to peptide receptors on tumors,are summarized in the second part of the review. | Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally | 2014 | World Journal of Gastroenterology2014，20，20： | 3 |
| 5 | Diabetic cardiomyopathy: mechanisms and therapeutic targets显示文摘 | Pavan K Battiprolu Thomas G Gillette Zhao V Wang Sergio Lavandero Joseph A Hill | 2010 | Drug Discovery Today: Disease Mechanisms2010，，2： | 2 |
| 6 | Reninoma: case report and literature review显示文摘 | Lara Wong Thomas HS Hsu Mark G Perlroth Lawrence V Hofmann Claudia M Haynes Laurence Katznelson | 2008 | Journal of Hypertension2008，，2： | 2 |
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| 10 | On the nucleation and growth of AhCuMg (S1 in AI-Li-Cu-Mg and AI-Cu-Mg alloys显示文摘 | RADMILOVIC V THOMAS G SHIFLET G J STARKE E A | 1989 | Scripta Metall1989，23，7： | 1 |
| 11 | Measurement,analysis,and display of haptic signals during surgical cutting 显示文摘 | Stephanie G V H Vanessa C A O Thomas S | 2002 | Presence2002，11，6： | 1 |
| 12 | Endogenous estrogen and postmenopausal breast cancer: a quantitative review显示文摘 | Thomas H V Reeves G K Key T J | 1997 | Cancer Causes Control1997，8，： | 1 |
| 13 | Heterologous expression and site-directed mutagenesis of the 1-aminocyclopropane-1-carboxylate oxidase from kiwifruit显示文摘 | LAY V J PRESCOTT A G THOMAS P G | 1996 | Eru J Biochem1996，242，： | 1 |
| 14 | Germinal transpositions of the maize element Dissocia-tion from T-DNA loci in tomato显示文摘 | Carroll B J Klimyuk V I Thomas C M Bishop G J HarrisonK Scofield S R Jones J D G | | 0，，： | 1 |
| 15 | Recem advances in the development of GTR/GBR membranes for periodontal regen- eration-a materials perspective显示文摘 | Bottino MC Thomas V Schmidt G | 2012 | Dent Mater2012，28，7： | 1 |
| 16 | A Study on the Chemical Spray Deposition of Zinc Oxide Thin Films and Their Structural and Electrical Properties显示文摘 | Gopchandran K G Thomas P V | 1999 | Materials Chemistry and Physics1999，58，1： | 1 |
| 17 | Self- incompatibility triggers programmed cell death in papaver pollen显示文摘 | Thomas S G Franklin- Tong V E | 2004 | Nature2004，429，30： | 1 |
| 18 | Imagequality assessment based on a degradation model显示文摘 | NARANJAN D V THOMAS D K WILSONS S G | 2000 | IEEE Trans Image Proceedings2000，9，4： | 1 |
| 19 | Highly Pathogenic H5N1 Influerza Virus in Smuggled Thai Eagles,Belgium显示文摘 | BORM S V THOMAS I HANQUET G | 2005 | EID2005，11，5： | 1 |
| 20 | Occurrence and ability of phosphate solubilizing fungi from coconut plant soils 显示文摘 | Thomas G V | 1985 | Plant and Soil1985，87，： | 1 |
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