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| 1 | Immune response to an indigenously developed r-Hepatitis B vaccine in mixed population: Study of an accelerated vaccination schedule显示文摘AIM: To establish the safety and efficacy of an indigenously developed r-hepatitis B vaccine using an accelerated schedule and to highlight the social awareness and commitment in preventing the spreading of hepatitis B virus infection.METHODS: The study was a multicentric, double blind,randomized (3:1) study using three doses of vaccine immunization schedule (20 μg for those above 10 years old and 10 μg for those below 10 years old) on d 0, 30and 60. One hundred and sixty-six subjects were enrolled(87 males and 76 females aged 5-35 years). The main outcome measure was assessment of immunogenicity and safety.RESULTS: A 100% seroconversion response was observed on the 30th d after the 1st injection in both the experimental groups. The sero-protection data reported a 41.2-65.6% response on the 30th d after the 1st injection and reached 100% on the 60th d. Descriptive statical analysis showed a geometric mean titer value of 13.77 mIU/mL in the test (BEVAC) group and 10.95 mIU/mL in the commercial control (ENGERIX-B) group on the 30th d after the 1st injection. The response on the 60th d showed a geometric mean titre value (GMT) of 519.84 mIU/mL in the BEVAC group and 475.46 mIU/mL in the ENGERIX-B group. On the 90th d, the antibody titer response was observed to be 2627.58 mIU/mL in the BEVAC group and 2272.72 mIU/mL in the ENGERIX-B group. Two subjects in each group experienced pains at injection site after the first vaccination. A total of six subjects in both groups experienced a solicited adverse reaction, which included pains, swelling and redness at the injection site, three subjects in the group-B had a pain at the injection site after the third dose. No other serious adverse events occurred and no dose-related local or general symptoms were observed during the study.CONCLUSION: The vaccine is safe, efficacious and immunogenic in comparison with the well documented ENGERIX-B. | A Chowdhury A Santra CM Habibullah AA Khan J Karunakaramaiah TSA Kishore AVR Raju S Lahiri | 2005 | World Journal of Gastroenterology2005，11，7： | 12 |
| 2 | Application of real-time PCR, DGGE fingerprinting and culture-based method to evaluate the effectiveness of intrinsic bioremediation on the control of petroleum-hydrocarbon plume 显示文摘 | KAO C M CHEN C S TSA F Y | 2010 | Journal of Hazardous Materials2010，178，13： | 1 |
| 3 | Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways显示文摘 | Huang W W Ko S W Tsa H Y | 2011 | Int J Oncology2011，38，4： | 1 |
| 4 | Application of real-time PCR,DGGE fingerprinting,and culture-based method to evaluate the effectiveness of intrinsic bioremediation on the control of petroleum-hydrocarbon plume 显示文摘 | Kao C M Chen C S Tsa F Y Yang K H Chien C C Liang S H Yang C A Chen S C | 2010 | Journal of Hazardous Materials2010，178，123： | 1 |
| 5 | Variations in the NRAMP1 gene and susceptibility of tuberculosis in Taiwanese显示文摘 | LIAW Y S TSA I WU J J | 2002 | Int J Tuberc Lung Dis2002，6，5： | 1 |
| 6 | Post-Cu CMP cleaning for colloidal silica abrasive removal 显示文摘 | CHEN P L CHEN J H TSA! M S | 2004 | Microelectronic Engineering2004，75，4： | 1 |
| 7 | Nocardia seriolae in-fection in the three striped tigerfish, Terapon jarbua ( Forsskal)显示文摘 | WANG PC CHEN S D TSA M Al | 2009 | J Fish Dis2009，32，4： | 1 |
| 8 | Glycosylated hemoglobin level and number of oral antidiabetic drugs predict whether or not glyccmic tar- get is achieved in insulin - requiring type 2 diabetes 显示文摘 | Lin S D Tsa S T Tu S T | 2015 | Primary Care Diabetes2015，9，2： | 1 |
| 9 | Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line 显示文摘 | Tsas F Brenner C Mauen S | 2005 | FEBS Lett2005，579，1： | 1 |
| 10 | A numerically stable algorithm for discrete ordinate method radiative transfer in multiple scattering and emitting layered media显示文摘 | Tsa S C Wiscombe W | 1988 | Applied Optics1988，27，12： | 1 |
| 11 | Vanadylsulfate, tau- rine,and combined vanadyl sulfate and taurine treatments in diarats: effects on the oxidative and antioxidative systems显示文摘 | Tsa S Sarando 1 E Ayvalik S Z | 2007 | Arch Med Res2007，38，3： | 1 |
| 12 | Development of a dynamicsbased NURBS interpolator with real-time look-ahead algorithm 显示文摘 | Lin M T Tsa M S Yau H T | 2007 | International Journal of Machine Tools & Manufacture2007，47，7： | 1 |
| 13 | A sludy of organic working fluids on system efficiency of an ORC using low-grade energy sources 显示文摘 | HUNG T C WANG S K KUO C H PEI B S TSA] K F | 2010 | Energy2010，35，3： | 1 |
| 14 | Application of real-timePCR-DGGE fingerprinting, and culture-based method to evaluatethe effectiveness of intrinsic bioremediation on the control ofpetroleum-hydrocarbon plume显示文摘 | KAO C M CHEN C S TSA F Y | 2010 | J Hazard Materi2010，178，40： | 1 |
| 15 | Application of real-time PCR, DGGE fingerprinting, and culture-based method to evaluate the effectiveness of intrinsic bioremediation on the control of petroleum-hydrocarbon plume显示文摘 | KAO C M CHEN C S TSA F Y | 2010 | Journal of Hazardous Materials2010，178，13： | 1 |
| 16 | Electronic properties, structure and temperature-dependent composition of nickel deposited on rutile titanium dioxide( 110) surfaces显示文摘 | KAO C TSA! S BAHL M | 1980 | Surf Sci1980，95，1： | 1 |
| 17 | Vanadyl sulfate, tau-rine, and combined vanadyl sulfate and taurine treatments in dia-betic rats: effects on the oxidative and antioxidative systems 显示文摘 | Tsa S Sarandol E Ayvalik S Z | 2007 | Arch Med R2007，38，3： | 1 |
| 18 | A boundary method for outli- er detection based on support vector domain description 显示文摘 | Guo S M Chen L C Tsa I J S H | 2009 | Pattern Recognition2009，42，1： | 1 |
| 19 | The effect of Controlling Shareholders Excess Board Seat Control on Financial Restatement: Evidence from Taiwan显示文摘 | Young C S Tsa i L C Hsu H W | | 0，，03： | 1 |
| 20 | Formation of heavy metal species during PVC-containing simulated MSW incineration显示文摘 | CHIANG K Y WANG K S TSA C C | 2001 | Journal of Environmental Science\s&\shealth: part A Toxic/hazardous Substances & Environmental Engineering2001，36，5： | 1 |
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