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| 1 | High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response显示文摘伪 - Galactosylceramide (伪 - GC ) 广泛地被知道激活不变的自然漂亮 T (iNKT ) 压制髓磷脂的房间抗原特定的 Th1 回答,保护易受影响的老鼠免于试验性的自体免疫的脑脊髓炎(EAE ) 。这里,我们表明那高加重,而非改善的伪 - GC 开 EAE 的意外发现。当与高剂量的伪 - GC 对待的 MOG35-55-specific T 房间被变成 na 时,类似的结果被观察 ? ve syngeneic 接受者老鼠。进一步的学习证明伪 - GC 的高剂量直接通过 STAT3 的 phosphorylation 和 NF-魏 B 的激活由 CD4+CD44+ 记忆 T 房间的激活提高 Th17 和 Th1 反应。不同于由伪 - GC 的低剂量的 iNKT 房间的激活,伪 - GC 的高剂量直接交往了, CD1d 在 T 房间上表示了并且激活 Th17 和 Th1 房间。而且,介绍抗原的房间(APC ) 主要表示 CD1d1,而 CD4+ T 房间快车 CD1d2 的多数。由 RNAi 的 CD1d1 或 CD1d2 基因表示击倒分别地防碍 iNKT 或 Th17/Th1 房间的激活。因此,伪 - GC 处理能改善或变得更坏由雇佣取决于剂量的 APC 或 Th17/Th1 房间的 EAE 使用了。 | Gaochao Qian Xia Qin Ying Qin Zang Baoxue Ge Taylor B Guo Bing Wan Lei Fang Jingwu Z Zhang | 2010 | Cell Research2010，20，4： | 3 |
| 2 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | Lime roasting of pyrite显示文摘 | Taylor P R Yin Z B Barrtlet R W | 1990 | Gold1990，6，： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Evaluation of a pooling method for routine anti-HCV screening of blood donors to lower the cost burden on blood banks in countries under development显示文摘 | GARCIA Z TAYLOR L RUANO A | 1998 | Journal of Medical Virology1998，49，3： | 1 |
| 6 | Structure and composition of selectively cut and uncut Abies-Tsuga forest in Wolong natural reserve and implica- tions for Panda conservation in China 显示文摘 | Taylor A H Qing Z S | 1989 | Biological Conservation1989，47，2： | 1 |
| 7 | Variation of the point spectrum under compact perturbations显示文摘 | HERRERO D A Taylor T J Wang Z Y | 1988 | Operator Theory: Advances and Applications1988，32，： | 1 |
| 8 | Elevated cortical glutamate in young people at increased familial risk of depression 显示文摘 | Taylor M J Mannie Z N Norhury R | 2011 | Int J Neuropsychopharmacol2011，14，： | 1 |
| 9 | Variation of the point spectrum under compact perturbations 显示文摘 | HERRERO D A TAYLOR T J WANG Z Y | 1988 | Oper Theory Adv Appl1988，32，： | 1 |
| 10 | Regeneration patterns in old - growth Abies - Betula forests in the Wolong Natural Reserve, Siehuan China显示文摘 | Taylor A H & Z Qin | 1988 | Journal of Ecology1988，76，： | 1 |
| 11 | NKCCl knockdowndecreases neuron production through GABA(A)-regulatedneural progenitor proliferation and delays dendrite develop-ment显示文摘 | Young S Z Taylor M M Wu St | 2012 | J Neurosci2012，32，13： | 1 |
| 12 | Impacts of human factors on wildlife habitat: framework and case study on change habitat for giant pandas 显示文摘 | Liu J G Ouyang Z Y Taylor W | 1999 | Conservation Biology1999，，13： | 1 |
| 13 | Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumoor necrosis factor alpha signal- ling 显示文摘 | Taylor CA Sun Z Cliche DO | 2007 | Exp Cell Res2007，313，3： | 1 |
| 14 | Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell careinoma 显示文摘 | Li Z J Mack S C Mak T H Angers S Taylor M D Hui C C | 2014 | Oncogene2014，33，： | 1 |
| 15 | Structure and dynamics of sub-alpine forests显示文摘 | Taylor A H Qin Z S Liu J | 1996 | Vegetation1996，134，： | 1 |
| 16 | Reducing Ambigui- ty in Tagging Systems with Folksonomy Search Expansion 显示文摘 | Jeff Z Pan Stuart Taylor Edward Thomas | 2009 | The Semantic Web: Research and Applications Lecture Notes in Computer Science Volume 55542009，，： | 1 |
| 17 | Apoptosis induction by elFSA1involves activation of the intrinsic mitochondrial pathway 显示文摘 | Sun Z Cheng Z Taylor CA | 2010 | J Cell Physio12010，223，3： | 1 |
| 18 | Regulation and execution of molecular disassembly and catabolism during senescence显示文摘 | Hopkins M Taylor C Liu Z | 2007 | New Phytologist2007，175，： | 1 |
| 19 | Regenerating functional myocardium: improved perfolrnance after skeletal myoblast transplantation 显示文摘 | Taylor D A Atkins B Z Hungspreugs P | 1998 | Nat Med1998，4，8： | 1 |
| 20 | Effects of Exercise on Brain Function:Role of Free Radicals显示文摘 | Radak Z Kumagal S Taylor AW | 2007 | Appl Physio Nutr Metab2007，32，5： | 1 |
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