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| 1 | Dispersive liquid-liquid microextraction,an effective tool for the determination of synthetic cannabinoids in oral fluid by liquid chromatography-tandem mass spectrometry显示文摘In the present work,dispersive liquid-liquid microextraction(DLLME)was used to extract six synthetic cannabinoids(JWH-018,JWH-019,JWH-073,JWH-200,or WIN 55,225,JWH-250,and AM-694)from oral fluids.A rapid baseline separation of the analytes was achieved on a bidentate octadecyl silica hydride phase(Cogent Bidentate C18;4.6 mm×250 mm,4μm)maintained at 37℃,by eluting in isocratic conditions(water:acetonitrile(25:75,V/V)).Detection was performed using positive electrospray ionization-tandem mass spectrometry.The parameters affecting DLLME(pH and ionic strength of the aqueous phase,type and volume of the extractant and dispersive solvent,vortex and centrifugation time)were optimized for maximizing yields.In particular,using 0.5 mL of oral fluid,acetonitrile(1 mL),was identified as the best option,both as a solvent to precipitate proteins and as a dispersing solvent in the DLLME procedure.To select an extraction solvent,a low transition temperature mixture(LTTM;composed of sesamol and chlorine chloride with a molar ratio of 1:3)and dichloromethane were compared;the latter(100μL)was proved to be a better extractant,with recoveries ranging from 73%to 101%by vortexing for 2 min.The method was validated according to the guidelines of Food and Drug Administration bioanalytical methods:intra-day and inter-day precisions ranged between 4%and 18%depending on the spike level and analyte;limits of detection spanned from 2 to 18 ng/mL;matrixmatched calibration curves were characterized by determination coefficients greater than 0.9914.Finally,the extraction procedure was compared with previous methods and with innovative techniques,presenting superior reliability,rapidity,simplicity,inexpensiveness,and efficiency. | Pierpaolo Tomai Alessandra Gentili Roberta Curini Rossella Gottardo Franco Tagliaro Salvatore Fanali | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 4 |
| 2 | Effects of K(ATP) chennel blockade by glibenclamide on the warm-up phenomenon显示文摘 | Danesi A Ghini AS | 1999 | Eur Heart J1999，20，3： | 1 |
| 3 | Gap junction communication in cultured human lung carcinoma cells显示文摘 | Tomai E Brownell H L Tufescu T V | 1999 | Lung1999，23，3： | 1 |
| 4 | The antiviral activity of Toll-like re- ceptor 7 and 7/8 agonists 显示文摘 | Miller RL Meng TC Tomai MA | 2008 | Drug News Perspect2008，21，2： | 1 |
| 5 | Unstable angina and elevated c-reactive protein levels predict enhanced vasoreaetivity of the culprit lesion显示文摘 | Tomai F Crea F Gaspardone A | 2001 | Circulation2001，104，13： | 1 |
| 6 | C reactive protein and mierovaseular function 显示文摘 | TOMAI F | 2004 | Heart2004，90，7： | 1 |
| 7 | Clini- cal outcome after endovascuIar, surgical or hy- brid revascularisation in patients with com- bined carotid and coronary artery disease:the Finalised Research In ENDovascular Strategies Study Group ( FRIENDS ) 显示文摘 | Ribichini F Tomai F Reimers B | 2010 | EuroInterven- tion2010，6，3： | 1 |
| 8 | Unstable angina and elevated C-reactive protein levels predict enhanced va- soreactivity of the eul prit lesion 显示文摘 | Tomai F Crea F Gaspardone A | 2001 | Circulation2001，104，74： | 1 |
| 9 | Immunosuppressive therapy for the prevention of restenosis after coronary artery stent implantation (IMPRESS Study)显示文摘 | Versaei F Gaspardone A Tomai F | 2002 | J Am Coil Cardiol2002，40，11： | 1 |
| 10 | Novel processing af lithium mananes sihcate nanomaterials for Li-ion batteries applications 显示文摘 | DEVARAJU M K TOMAI T UNEMOTO A | 2013 | RSC advances2013，3，： | 1 |
| 11 | C-Reactive protein, clinical outcome, and restenosis rates after implantation of different drug-eluting stents显示文摘 | Gaspardone A Versaci F Tomai F | 2006 | Am J Cardiol2006，97，： | 1 |
| 12 | Does IOR occur in discrimination tasks? Yes, it does, but later显示文摘 | Lupiainez J Milan E G Tomay F J | 1997 | Perception &Psycophysics1997，59，8： | 1 |
| 13 | lmmunosuppressive Therapy for the Prevention of Restenosis after Coronary Artery Stent Implantation ( IMPRESS Study) 显示文摘 | Versaci F Gaspardone A Tomai F | 2002 | J Am Coll Cardiol2002，40，11： | 1 |
| 14 | Ischemic preconditioning in humans models, mediators, and clinical relevance 显示文摘 | Tomai F Grea F Chiariello L | 1999 | Circulation1999，100，5： | 1 |
| 15 | The antiviral activity of Toll-like receptor 7 and 7/8 agonists 显示文摘 | Miller RL Meng TC Tomai MA | 2008 | Drug News Perspect2008，21，2： | 1 |
| 16 | Unstable angina and elevated C-reactive protein levels predict enhanced vasoreactivity of the culprit lesion 显示文摘 | Tomai F Crca F Gaspardone A | 2001 | Circulation2001，104，8： | 1 |
| 17 | Ischaemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+channel blocker显示文摘 | Crea F Gaspardone A | 1994 | Circulation1994，90，： | 1 |
| 18 | Resiquimod and other immune response modifiers as vaccine adjuvants 显示文摘 | Tomai MA Miller RL Lipson KE | 2007 | Expert Rev Vaccines2007，6，5： | 1 |
| 19 | Exercisc-induced myocardial ischemia triggers the early phase of preconditioning but not the late phase显示文摘 | Tomai F Perino M Ghini AS | 1999 | Am J Cardiol1999，83，4： | 1 |
| 20 | Effects of A1 adenosine receptor blockade by bamiphylline on ischemic preconditioning during coronary angioplasty显示文摘 | Tomai F Crea F Gaspardone A | 1996 | Eur Heart J1996，17，： | 1 |
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