|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Biofilm formation as microbial development 显示文摘 | O 'Toole G Kaplan H B Kolter R | 2000 | Annu Rev Micmbiol2000，54，： | 1 |
| 3 | Dysregulation of Hedgehog,Wnt and Notch signallingpathways in breast cancer显示文摘 | Zardawi S J O’Toole S A Sutherland R L | 2009 | Histol Histopathol2009，24，38： | 1 |
| 4 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 5 | Rare functioning pancreaticendocrine tumors显示文摘 | O′Toole D Salazar R Falconi M | | 0，，03： | 1 |
| 6 | Initiation of biofilm formation in Pseudomo- nasfluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis显示文摘 | O'TOOLE G A KOLTER R | 1998 | Molecular Microbiol1998，28，3： | 1 |
| 7 | Photolysis and the dirnethylsulfide (DMS) summer paradox in the Sargasso Sea显示文摘 | TOOLED A KIEBER D J KIENE R P | 2003 | Lim- nology and Oceanography2003，48，3： | 1 |
| 8 | Biofilm formation as microbial development显示文摘 | O'Toole G Kaplan H B Kolter R | 2000 | Annu Rev Microbiol2000，54，： | 1 |
| 9 | Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum显示文摘 | O'TOOLE R VON H J ROSQVIST R | 2004 | Microb Pathog2004，37，1： | 1 |
| 10 | Responses of seven diverse rice cultivars to water deficits I · Stress development, canopy temperature, leaf rolling and growth显示文摘 | Turner N C O’Toole J C Cruz R T | 1986 | Field Crops Research1986，13，： | 1 |
| 11 | Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells: Implications in Acute Myocardial Infarction显示文摘 | Roland Schmidt Andreas Bültmann Martin Ungerer Nader Joghetaei ?zgür Bülbül Sven Thieme Triantafyllos Chavakis Bryan P. Toole Meinrad Gawaz Albert Sch?mig Andreas E. May | 2006 | Circulation2006，，6： | 1 |
| 12 | Yield and viability of carrot seeds as affected by position of umbels and time of harvest 显示文摘 | Hawthorn L R Tool E H Toole V H | 1962 | Proc Amer Soc Hort Sci1962，，80： | 1 |
| 13 | Biofilm formation as microbial development 显示文摘 | O'Toole G Kaplan HB Kolter R | 2000 | Annu Rev Microbiol2000，54，： | 1 |
| 14 | Initiation of biofilm formation in Pseudomonasfluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis 显示文摘 | O'Toole G A Kolter R | 1998 | Molecular Microbiology1998，28，3： | 1 |
| 15 | Biofilm formation as microbial development 显示文摘 | O' Toole G Kaplan HB Kolter R | 2000 | Annu Rev Microbiol2000，54，1： | 1 |
| 16 | Do traction radiographs of distal radial fractures influence fracture characterization and treatment显示文摘 | Goldwyn E Pensy R O'Toole RV | | 0，，22： | 1 |
| 17 | The gene encoding R-spondin 4 (RSPO4) a secreted protein implicated in Wnt signaling, is mutated in in herited anonychia显示文摘 | Blaydon D C Ishii Y O'Toole E A Unsworth H C Teh M T R schendorf F | 2006 | Nat Genet2006，38，： | 1 |
| 18 | Chemotactic motility is required for invasion of the host by the fish pathogen Vibrio anguillarum显示文摘 | O'Toole R Milton D L Wolf-Watz H | 1996 | Molecular Microbiol- ogy1996，19，3： | 1 |
| 19 | A novel and sensitive ELISA reveals that the soluble form of IL-13Ralpha2 is not expressed in plasma of healthy or asthmatic subjects显示文摘 | O Toole M Legault H Ramsey R | | 0，，04： | 1 |
| 20 | Guideline of the American College of Obstetricians and Gynecologists for exercise during pregnancy and the postpartum period显示文摘 | Artal R O'Toole M | 2003 | Br J Sports Med2003，37，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员