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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration显示文摘 | Arora S Ranade AR Tran NL Nasser S Sridhar S Korn RL Ross JT Dhruv H Foss KM Sibenaller Z Ryken T Gotway MB Kim S Weiss GJ | 2011 | 中国神经肿瘤杂志2011，9，1： | 30 |
| 3 | OASIS~ WAX固相提取吸附剂用于水及组织中PFOS和相关化合物的UPLC~/MS定量分析显示文摘近年来,全氟化合物(PFCs)如全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)其分子结构如图1所示,已经被明确为持久性有机污染物(POPs),并在环境中普遍存在.由于PFCs可能具有毒性和生物积聚性,因此,对食品、饮用水、组织、血浆和全血中PFCs分析方法的建立受到越来越多的关注. | Michael S Young KimVan Tran | 2007 | 环境化学2007，26，1： | 13 |
| 4 | Accuracy of biometric formulae for intraocular lens power calculation in a teaching hospital显示文摘AIM: To evaluate the accuracy of three commonly used biometric formulae across different axial lengths(ALs) at one United States Veterans Affairs teaching hospital.METHODS: A retrospective chart review was conducted from November 2013 to May 2018. One eye of each patient who underwent cataract surgery with a monofocal intraocular lens(IOL) was included. The range of postoperative follow-up period was from 3 wk to 4 mo. The Holladay 2, Barrett Universal II, and Hill-Radial Basis Function(Hill-RBF) formulae were used to predict the postoperative refraction for all cataract surgeries. For each formula, we calculated the prediction errors [including mean absolute prediction error(MAE)] and the percentage of eyes within ±0.25 diopter(D) and ±0.5 D of predicted refraction. We performed subgroup analyses for short(AL<22.0 mm), medium(AL 22.0-25.0 mm), and long eyes(AL>25.0 mm).RESULTS: A total of 1131 patients were screened, and 909 met the inclusion criteria. Resident ophthalmologists were the primary surgeons in 710(78.1%) cases. We found no statistically significant difference in predictive accuracy among the three formulae over the entire AL range or in the short, medium, and long eye subgroups. Across the entire AL range, the Hill-RBF formula resulted in the lowest MAE(0.384 D) and the highest percentage of eyes with postoperative refraction within ±0.25 D(42.7%) and ±0.5 D(75.5%) of predicted. All three formulae had the highest MAEs(>0.5 D) and lowest percentage within ±0.5 D of predicted refraction(<55%) in short eyes.CONCLUSION: In cataract surgery patients at our teaching hospital, three commonly used biometric formulae demonstrate similar refractive accuracy across all ALs. Short eyes pose the greatest challenge to predicting postoperative refractive error. | Kevin S Tang Elaine M Tran Allison J Chen David R Rivera Jorge J Rivera Paul B Greenberg | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 5 | Dysphagia after vertical sleeve gastrectomy: Evaluation of risk factors and assessment of endoscopic intervention显示文摘AIM To evaluate the risks of medical conditions, evaluate gastric sleeve narrowing, and assess hydrostatic balloon dilatation to treat dysphagia after vertical sleeve gastrectomy(VSG).METHODS VSG is being performed more frequently worldwide as a treatment for medically-complicated obesity, and dysphagia is common post-operatively. We hypothesize that post-operative dysphagia is related to underlying medical conditions or narrowing of the gastric sleeve. This is a retrospective, single institution study of consecutive patients who underwent sleeve gastrectomy from 2013 to 2015. Patients with previous bariatric procedures were excluded. Narrowing of a gastric sleeve includes: inability to pass a 9.6 mm gastroscope due to stenosis or sharp angulation or spiral hindering its passage.RESULTS Of 400 consecutive patients, 352 are included; the prevalence of dysphagia is 22.7%; 33 patients(9.3%) have narrowing of the sleeve with 25(7.1%) having sharp angulation or a spiral while 8(2.3%) have a stenosis. All 33 patients underwent balloon dilatation of the gastric sleeve and dysphagia resolved in 13 patients(39%); 10 patients(30%) noted resolution of dysphagia after two additional dilatations. In a multivariate model, medical conditions associated with post-operative dysphagia include diabetes mellitus, symptoms of esophageal reflux, a low whole blood thiamine level, hypothyroidism, use of non-steroidal anti-inflammatory drugs, and use of opioids.CONCLUSION Narrowing of the gastric sleeve and gastric sleeve stenosis are common after VSG. Endoscopic balloon dilatations of the gastric sleeve resolves dysphagia in 69% of patients. | Anand Nath Sayali Yewale Tung Tran John S Brebbia Timothy R Shope Timothy R Koch | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 6 | Internal nutrient efficiencies of irrigated lowland rice in tropical and subtropical Asia显示文摘 | C Witt A Dobermann S Abdulrachman H.C Gines Wang Guanghuo R Nagarajan S Satawatananont Tran Thuc Son Pham Sy Tan Le Van Tiem G.C Simbahan D.C Olk | 1999 | Field Crops Research1999，，2： | 2 |
| 7 | Metal Hydride Compaccts for Hydride Isotope Separation显示文摘 | Heung L K Tran R S | 1991 | J Less-Common Met1991，，： | 2 |
| 8 | Effects of VHL deficiency on endolymphatic duct and sac 显示文摘 | GI sker S Lonser RR Tran MG | 2005 | Cancer Res2005，65，10： | 1 |
| 9 | Neuro-fuzzy TSK network for approximation of static and dynamic functions 显示文摘 | Tran Haoi L Osowski S | 2002 | Control and Cybernetics2002，31，2： | 1 |
| 10 | Aspirin resistance显示文摘 | TRAN H A ANAND S S HANKEY G J | 2007 | Thromb Res2007，120，3： | 1 |
| 11 | R-Spondin family members regulate the Wnt pathway by a common mechanism显示文摘 | Kim K A Wagle M Tran K Zhan X Dixon M A Liu S | 2008 | Mol Biol Cell2008，19，： | 1 |
| 12 | Separation of carbohydrate-mediated microheterogeneity of recombinant human erythropoietin by free solution capillary electrophoresis effects of pH, buffer type and organic additives 显示文摘 | TRAN A D PARK S LISI P J | 1991 | J Chromatogr: A1991，542，： | 1 |
| 13 | Differential ex-pression of isoflavone biosynthetic genes in soybean during water deficits显示文摘 | GONZALEZ J G GUTTIKONDA S K TRAN L S P | 2010 | Plant Cell Physiol2010，51，6： | 1 |
| 14 | Physiological and molecular approaches to improve drought re- sistance in soybean显示文摘 | Manavalan L P Guttikonda S K Tran L S | 2009 | Plant Cell Physiol2009，50，7： | 1 |
| 15 | A randomized controlled trial of sequentially bilateral prefrontal cortex repetitive transcranial magnetic stimulation in the treatment of negative symptoms in schizophrenia显示文摘 | Barr M S Farzan F Tran L C | 2012 | Brain Stimul2012，5，3： | 1 |
| 16 | Phenamide, a fungicidal metabolite from Streptomyces albospinus A19301 taxonomy, fermentation, isolation, physico-chemical and biological properties 显示文摘 | Makkar N S Nickson T E Tran M | 1995 | The Journal of Antibiotics1995，48，5： | 1 |
| 17 | Effects of hydrothermal aging on NH3 -SCR reaction over Cu/zeolites 显示文摘 | Kwak J H Tran D Burton S D | 2012 | Journal of Catalysis2012，287，： | 1 |
| 18 | Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel显示文摘 | Ang L Palakodeti V Khalid A Tsimikas S Idrees Z Tran P | 2008 | J Am Coll Cardiol2008，52，： | 1 |
| 19 | Real-time wavelet-based coordinated control of hybrid energy storage systems for denoising and flattening wind poweroutput显示文摘 | Tran T T Ahn S Choi J | 2014 | Energies2014，7，10： | 1 |
| 20 | An autopsy study of a fouled reverse osmosis membrane dement used in a brackish water treatment plant 显示文摘 | TRAN T BOLTO B GRAY S | 2007 | Water Research2007，41，17： | 1 |
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