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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 3 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 4 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 5 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 6 | Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure 显示文摘 | Luchner A Stevens TL Borgeson DD | 1998 | Am J Physiol1998，274，52： | 1 |
| 7 | Arthroscopic-assisted surgical technique for treating patella fractures 显示文摘 | Aponte TL Muscolo DL | 2002 | Arthroscopy2002，18，6： | 1 |
| 8 | Corporate Ownership Around the World显示文摘 | La Porta tL Lopez--de--Silanes E Shleifer A | 1999 | Journal of Finance1999，54，2： | 1 |
| 9 | Regulatory role of p27kip1 in the mouse and human testis显示文摘 | Beumer TL Kiyokawa H Roepers-Gajadien HL van den Bos LA Lock TM Gademan IS Rutgers DH Koff A de Rooij DG | | 0，，： | 1 |
| 10 | An outbreak of2009pandemic influenza a(H1N1)virus infection in an elementary school in pennsylvania显示文摘 | Marchbanks TL Bhattarai A Fagan RP | 2011 | Clin Infect Dis2011，52，1： | 1 |
| 11 | Inflammatory micro-environment and tumor necrosis factor alpha as modulators of periostin and CCN2 expression in human non-healing skin wounds and dermal fibroblasts 显示文摘 | Elliott CG Forbes TL Leask A | 2015 | Matrix Biol2015，43，： | 1 |
| 12 | A review of the mechanisms implicated in the pathogenesis of the diabetic foot显示文摘 | Dinh TL Veves A | 2005 | Int J Low Extrem Wounds2005，4，： | 1 |
| 13 | Progression and treatment of HER-2-positive breast cancer显示文摘 | Davoli A Hocevar BA Brown TL | 2010 | Cancer Chemother Pharmacol2010，65，4： | 1 |
| 14 | The use of dye sur- rogates to illustrate local anesthetic drug sequestration by lipid emulsion: a visual demonstration of the lipid sink effect 显示文摘 | Papadopoulou A Willers JW Samuels TL | 2012 | Reg Anesth Pain Med2012，37，2： | 1 |
| 15 | Gapped BLAST and PSI - BLAST: a new generation of protein database search programs 显示文摘 | Altschul S F Madden TL Chffer A A | 1997 | Nucleic Acids Res1997，25，17： | 1 |
| 16 | Selectivesurvival of naturally occurring human CD4+ CD25 +Foxp3 + regulatory T cells cultured with rapamycin 显示文摘 | Strauss L Whiteside TL Knights A | 2007 | JImmunol2007，178，1： | 1 |
| 17 | Neonatal mortality following transfusion of red cells with high plasma potassium levels显示文摘 | Hall TL Barnes A Miller JR | | 0，，07： | 1 |
| 18 | Biological synthesis of circular polypeptides 显示文摘 | Aboye TL Camarero J A | 2012 | J Biol Chem2012，287，27： | 1 |
| 19 | IDH1 and IDH2 mutation analysis inchronic- and blast-phase my- eloproliferative neoplasms显示文摘 | Pardanani A Lasho TL Finke CM | 2010 | Leukemia2010，24，6： | 1 |
| 20 | Calreticulin mutations and long-term survival in essential thmmboeythemia 显示文摘 | Tefferi A Wassie EA Lasho TL | 2014 | Leukemia2014，28，12： | 1 |
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