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| 1 | 柴达木北缘超高压变质带中的岛弧火山岩显示文摘青藏高原北部柴北缘发育一套与超高压变质带并行的早古生代岛弧火山岩带,岛弧火山岩以玄武岩类为主,包括一些中酸性岩类,岩石以普遍遭受绿片岩相蚀变为特征,区别于该地区普遍遭受角闪岩相区域变质的元古代的基性火山岩。该早古生代的岛孤火山岩显示三组地球化学特征:①VTG-Ⅰ,岛弧拉斑玄武岩(IAT);②VTG-Ⅱ,高Al次钙碱性-碱性过渡型玄武岩;③VTG-Ⅲ,较N-MORB更亏损的拉斑玄武岩(异常MORB)。研究认为前两组火山岩是成熟岛弧两个发育阶段的特征性产物:洋壳俯冲到陆壳的初用,由俯冲洋壳和地幔楔的部分熔融形成岛弧拉斑玄武岩(IAT),随着俯冲板块的速度加快和岛弧周围地壳的加厚,则形成钙碱性玄武岩(CA)、高Al玄武岩。第三组火山岩形成于弧间盆地,由亏损的地幔楔高度部分熔融形成比N-MORB亏损的的火山岩(异常MORB)。岛弧火山岩的锆石LA-ICP-MS法U-Pb年龄为514.2±8.5 Ma,说明柴北缘在早古生代发生过洋壳向陆壳的俯冲作用。鉴于该地区代表陆-陆俯冲作用的柴北缘超高压变质岩石也是形成于早古生代(494Ma),认为陆-陆俯冲作用发生在洋-陆俯冲作用之后,二者时间和空间相伴随。 | 史仁灯 杨经绥 吴才来 Tsuyoshi IIZUKA Takafumi HIRATA | 2004 | 地质学报2004，78，1： | 116 |
| 2 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 3 | Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. | Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo | 2013 | World Journal of Gastroenterology2013，19，17： | 19 |
| 4 | Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis显示文摘AIM To reveal better diagnostic markers for differentiating neuroendocrine tumor(NET) from solid-pseudopapillary neoplasm(SPN), focusing primarily on immunohistochemical analysis.METHODS We reviewed 30 pancreatic surgical specimens of NET(24 cases) and SPN(6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,vimentin, α-1-antitrypsin, CD10, and β-catenin.RESULTS E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. The other six markers were not useful because their expression overlapped widely between NETs and SPNs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles. Careful diagnosis is crucial as we actually found two confusing cases showing disagreement between the tumor morphology and immunohistochemical profiles.CONCLUSION E-cadherin, chromogranin A, and β-catenin were the most useful markers which should be employed for differentiating between NET and SPN. | Yusuke Ohara Tatsuya Oda Shinji Hashimoto Yoshimasa Akashi Ryoichi Miyamoto Tsuyoshi Enomoto Kaishi Satomi Yukio Morishita Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，38： | 19 |
| 5 | Start-up performances of dry anaerobic mesophilic and thermophilic digestions of organic solid wastes显示文摘器官的稳固的浪费的二干燥厌氧的消化为在 mesophilicand thermophilic conditions.The enzymaticactivities 下面调查启动表演在一个实验室规模批实验为 6weeks 被进行,即, beta-glucosidase , N-alpha-benzoyl-L-argininamide (咩) -hydrolysing 朊酶, ureaseand 磷酸酶活动在第一 2-3weeks 期间是 analysed.The BAA-hydrolysing 朊酶活动与低 pH 是低的,但是以后与 pH increase.beta-Glucosidase activityshowed t | LU Shu-guang IMAI Tsuyoshi UKITA Masao SEKINE Masahiko | 2007 | Journal of Environmental Sciences2007，19，4： | 19 |
| 6 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 7 | Role of 18F-fluorodeoxyglucose positron emission tomography imaging in surgery for pancreatic cancer显示文摘AIM: To evaluate the role of positron emission tomo-graphy using 18F-fluorodeoxyglucose (FDG-PET) in the surgical management of patients with pancreatic cancer, including the diagnosis, staging, and selection of patients for the subsequent surgical treatment.METHODS: This study involved 53 patients with proven primary pancreatic cancer. The sensitivity of diagnosing the primary cancer was examined for FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of carcinoembrionic antigens (CEA) and carbohydrate antigen 19-9 (CA19-9). Next, the accuracy of staging was compared between FDG-PET and CT. Finally, FDG-PET was analyzed semiquantitatively using the standard uptake value (SUV). The impact of the SUV on patient management was evaluated by examining the correlations between the SUV and the histological findings of cancer.RESULTS: The sensitivity of FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of CEA and CA19-9 were 92.5%, 88.7%, 46.4%, 37.7% and 69.8%, respectively. In staging, FDG-PET was superior to CT only in diagnosing distant disease (bone metastasis). For local staging, the sensitivity of CT was better than that of FDG-PET. The SUV did not correlate with the pTNM stage, grades, invasions to the vessels and nerve, or with the size of the tumor. However, there was a statistically significant difference (4.6 ± 2.9 vs 7.8 ± 4.5, P = 0.024) in the SUV between patients with respectable and unresectable disease.CONCLUSION: FDG-PET is thus considered to be useful in the diagnosis of pancreatic cancer. However, regarding the staging of the disease, FDG-PET is not considered to be a sufficiently accurate diagnostic modality. Although the SUV does not correlate with the patho-histological prognostic factors, it may be useful in selecting patients who should undergo subsequent surgical treatment. | Hisao Wakabayashi Yoshihiro Nishiyama Tsuyoshi Otani Takanori Sano Shinichi Yachida Keiichi Okano Kunihiko Izuishi Yasuyuki Suzuki | 2008 | World Journal of Gastroenterology2008，14，1： | 16 |
| 8 | Patients with early recurrence of hepatocellular carcinoma have poor prognosis显示文摘BACKGROUND: Early recurrence(ER) after hepatic resection(HR) is a poor prognostic factor for patients with hepatocellular carcinoma(HCC). This study aimed to identify the clinicopathological features, outcomes, and risk factors for ER after HR for small HCC in order to clarify the reasons why ER is a worse recurrence pattern.METHODS: We retrospectively examined 130 patients who underwent HR for small HCC(≤30 mm). Recurrence was classified into ER(<2 years) and late recurrence(LR)(≥2 years). The clinicopathological features, outcomes, and risk factors for ER were analyzed by multivariate analysis.RESULTS: ER was observed in 39 patients(30.0%). The survival rate of the ER group was significantly lower than that of the LR group(P<0.005), and ER was an independent prognostic factor for poor survival(P=0.0001). The ER group had a significantly higher frequency(P=0.0039) and shorter interval(P=0.027) of development to carcinoma beyond the Milan criteria(DBMC) compared with the LR group, and ER was an independent risk factor for DBMC(P<0.0001). Multi-nodularity, non-simple nodular type, and microvascular invasion were independent predictors for ER(P=0.012, 0.010, and 0.019, respectively).CONCLUSIONS: ER was a highly malignant recurrence pattern associated with DBMC and subsequent poor survival after HR for small HCC. Multi-nodularity, non-simple nodular type, and microvascular invasion predict ER, and taking these factors into consideration may be useful for the decision of the treatment strategy for small HCC after HR. | Tomoki Kobayashi Hiroshi Aikata Tsuyoshi Kobayashi Hideki Ohdan Koji Arihiro Kazuaki Chayama | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 15 |
| 9 | Arterial steroid injection therapy can inhibit the progression of severe acute hepatic failure toward fulminant liver failure显示文摘AIM: To utilize transcatheter arterial steroid injection therapy (TASIT) via the hepatic artery to reduce hepatic macrophage activity in patients with severe acute hepatic failure.METHODS: Thirty-four patients with severe acute hepatic failure were admitted to our hospital between June 2002 to June 2006 providing for the possibility of liver transplantation (LT). Seventeen patients were treated using traditional liver supportive procedures, and the other 17 patients additionally underwent TASIT with 1000 mg methylprednisolone per day for 3 continuous days. RESULTS: Of the 17 patients who received TASIT, 13 were cured without any complications, 2 died, and 2 underwent LT. Of the 17 patients who did not receive TASIT, 4 were self-limiting, 7 died, and 6 underwent LT. Univariate logistic analysis revealed that ascites, serum albumin, prothrombin time, platelet count, and TASIT were significant variables for predicating the prognosis. Multivariate logistic regression analysis using stepwise variable selection showed that prothrombin time, platelet count, and TASIT were independent predictive factors. CONCLUSION: TASIT might effectively prevent the progression of severe acute hepatic failure to a fatal stage of fulminant liver failure. | Kazuhiro Kotoh Munechika Enjoji Makoto Nakamuta Tsuyoshi Yoshimoto Motoyuki Kohjima Shusuke Morizono Shinsaku Yamashita Yuki Horikawa Kengo Yoshimitsu Tsuyoshi Tajima Yoshiki Asayama Kousei Ishigami Masakazu Hirakawa | 2006 | World Journal of Gastroenterology2006，12，41： | 13 |
| 10 | Real-time in situ three-dimensional integral videography and surgical navigation using augmented reality: a pilot study显示文摘To evaluate the feasibility and accuracy of a three-dimensional augmented reality system incorporating integral videography for imaging oral and maxillofacial regions, based on preoperative computed tomography data. Three-dimensional surface models of the jawbones, based on the computed tomography data, were used to create the integral videography images of a subject's maxillofacial area. The three-dimensional augmented reality system (integral videography display, computed tomography, a position tracker and a computer) was used to generate a three-dimensional overlay that was projected on the surgical site via a half-silvered mirror. Thereafter, a feasibility study was performed on a volunteer. The accuracy of this system was verified on a solid model while simulating bone resection. Positional registration was attained by identifying and tracking the patient/surgical instrument's position. Thus, integral videography images of jawbones, teeth and the surgical tool were superimposed in the correct position. Stereoscopic images viewed from various angles were accurately displayed. Change in the viewing angle did not negatively affect the surgeon's ability to simultaneously observe the three-dimensional images and the patient, without special glasses. The difference in three-dimensional position of each measuring point on the solid model and augmented reality navigation was almost negligible (<1 mm); this indicates that the system was highly accurate. This augmented reality system was highly accurate and effective for surgical navigation and for overlaying a three-dimensional computed tomography image on a patient's surgical area, enabling the surgeon to understand the positional relationship between the preoperative image and the actual surgical site, with the naked eye. | Hideyuki Suenaga Huy Hoang Tran Hongen Liao Ken Masamune Takeyoshi Dohi Kazuto Hoshi Yoshiyuki Mori Tsuyoshi Takato | 2013 | International Journal of Oral Science2013，5，2： | 11 |
| 11 | Effectiveness of exercise for osteoarthritis of the knee:A review of the literature显示文摘Osteoarthritis(OA)of the knee is the most common type of arthritis and the major cause of chronic musculoskeletal pain and mobility disability in the elderly.The objective of this paper is to discuss the effectiveness of exercise for OA of the knee based on a review of the literature.We reviewed the relevant literature,i.e.systematic reviews and meta-analyses searched using PubMed.Muscle strengthening and aerobic exercises are effective in reducing pain and improving physical function in patients with mild to moderate OA of the knee. | Jun Iwamoto Yoshihiro Sato Tsuyoshi Takeda Hideo Matsumoto | 2011 | World Journal of Orthopedics2011，2，5： | 11 |
| 12 | Treatment strategies for advanced hepatocellular carcinoma:Sorafenib vs hepatic arterial infusion chemotherapy显示文摘Sorafenib is used worldwide as a first-line standardsystemic agent for advanced hepatocellular carcinoma(HCC) on the basis of the results of two large-scale Phase Ⅲ trials. Conversely,hepatic arterial infusion chemotherapy(HAIC) is one of the most recommended treatments in Japan. Although there have been no randomized controlled trials comparing sorafenib with HAIC,several retrospective analyses have shown no significant differences in survival between the two therapies. Outcomes are favorable for HCC patients exhibiting macroscopic vascular invasion when treated with HAIC rather than sorafenib,whereas in HCC patients exhibiting extrahepatic spread or resistance to transcatheter arterial chemoembolization,good outcomes are achieved by treatment with sorafenib rather than HAIC. Additionally,sorafenib is generally used to treat patients with Child-Pugh A,while HAIC is indicated for those with either Child-Pugh A or B. Based on these findings,we reviewed treatment strategies for advanced HCC. We propose that sorafenib might be used as a first-line treatment for advanced HCC patients without macroscopic vascular invasion or Child-Pugh A,while HAIC is recommended for those with macroscopic vascular invasion or Child-Pugh A or B. Additional research is required to determine the best second-line treatment for HAIC non-responders with Child-Pugh B through future clinical trials. | Issei Saeki Takahiro Yamasaki Masaki Maeda Takuro Hisanaga Takuya Iwamoto Koichi Fujisawa Toshihiko Matsumoto Isao Hidaka Yoshio Marumoto Tsuyoshi Ishikawa Naoki Yamamoto Yutaka Suehiro Taro Takami Isao Sakaida | 2018 | World Journal of Hepatology2018，10，9： | 10 |
| 13 | Facile fabrication of stretchable Ag nanowire/polyurethane electrodes using high intensity pulsed light显示文摘银 nanowires (AgNWs ) 为下一代作为有希望的 nanomaterial 出现了可拉长的电子学。直到现在,然而, AgNWbased 部件的制造被复杂、费时间的步妨碍了。这里,我们介绍一灵巧,快并且为高度传导性、可拉长的 AgNW/polyurethane (PU ) 的制造的一步舞方法论合成电极基于一盏高紧张的搏动的灯(HIPL ) 技术。HIPL 同时在 50 s 以内在房间温度并且在空中改进了 wirewire 连接电导率和 wiresubstrate 粘附,省略复杂 transfercuringimplanting 过程。没有实质的底层损坏,由于在 AgNWs 的接口的 PU 的局部性的变丑, nanowires 嵌入很快被执行。产生电极保留了一个低表电阻(高电的传导性)< 甚至在 100% 紧张下面的 10 /sq,或在 1,000 连续 stretchingrelaxation 骑车以后,与 60% 的山峰紧张。制作电极为运动察觉作为一个传感器发现了立即的申请。而且基于我们的电极,一根轻射出二极管(带) 由综合可拉长的 AgNW 售票员开车被制作了。在结论,我们的现在的制造途径是快的,简单,可伸缩,并且 costefficient,为一个未来 roll-to-roll 过程使它成为一个好候选人。 | Yang Yang1 Su Ding Teppei Araki Jinting Jiu Tohru Sugahara Jun Wang Jan Vanfleteren Tsuyoshi Sekitani Katsuaki Suganuma | 2016 | Nano Research2016，9，2： | 10 |
| 14 | Neointimal coverage of sirolimus-eluting stents 6 months and 12 months after implantation: evaluation by optical coherence tomography显示文摘背景:光连贯断层摄影术(10 月) 是有约 10 microm 的分辨率的一种新成像形式并且能被采用设想 intracoronary 特征。Sirolimus-eluting stents (SES ) 由于在斯滕特氏印模膏神气上的推迟的 re-endothelialization 产生迟了的血栓,它可以导致尖锐心肌的梗塞或死亡。这研究被设计在培植以后与 10 月 6 日月和 12 个月评估 SES 的 re-endothelialization 和 neointimal 范围。方法:在学习注册的 36 个病人的一个总数在 SES 培植以后经历了 10 月检查 6 月(17 个病人) 和 12 个月(19 个病人) 。到 SES 神气上的容器墙和 neointimal 范围的神气并置被 10 月结果评估:46 SES 和 6561 口神气被分析。在 6 个月, 3041 口神气(98.7%) 是好添的, 39 口神气(1.3%) 是 malapposed。在 12 个月, 3434 口神气(98.6%) 是好添的, 47 口神气(1.4%) 是 malapposed。而且,仅仅在 6 个月(18.2%) 的 4SES 和在 12 个月(41.7%) 的 10 SES 被 neointimal 生长充分盖住。在 6 个月和 12 个月盖住分析神气的平均 neointimal 厚度是(42+/-28 ) microm 并且(88+/-32 ) microm 分别地。与 neointimal 厚度 <100 microm 在 12 个月(45.6%) 在 6 个月(72.1%) 和 1461 口神气有 1989 口神气。结论:10 月能在 SES 神气上设想神气并置到容器墙和 neointimal 范围。在 6 月、 12 月的后续考试,大多数神气被薄 neointima 盖住,但是很少全部 SES 显示出完整的范围。为了面对揭开的斯滕特氏印模膏阻止 late-stent 血栓,炫耀,更长双的反血小板药治疗应该被推荐。 | YAO Zhu-hua Tetsuo Matsubara Tsuyoshi Inada Yasuyoshi Suzuki Takahiko Suzuki | 2008 | Chinese Medical Journal2008，，6： | 9 |
| 15 | Clinical usefulness of biochemical markers of liver fibrosis in patients with nonalcoholic fatty liver disease显示文摘AIM: Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD), and progresses to the end stage of liver disease. Biochemical markers of liver fibrosis are strongly associated with the degree of histological liver fibrosis in patients with chronic liver disease.However, data are few on the usefulness of markers in NAFLD patients. The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type Ⅵ collagen 7S domain and hyaluronic acid.METHODS: One hundred and twelve patients with histologically proven NAFLD were studied.RESULTS: The histological stage of NAFLD correlated with several clinical and biochemical variables, the extent of hepatic fibrosis and the markers of liver fibrosis were relatively strong associated. The best cutoff values to detect NASH were assessed by using receiver operating characteristic analysis: type Ⅵ collagen 7S domain ≥5.0 ng/mL, hyaluronic acid ≥43 ng/mL. Both markers had a high positive predictive value: type Ⅵ collagen 7S domain, 86% and hyaluronic acid,92%. Diagnostic accuracies of these markers were evaluated to detect severe fibrosis. Both markers showed high negative predictive values: type Ⅵ collagen 7S domain (≥5.0 ng/mL),84% and hyaluronic acid (≥50 ng/mL), 78%, and were significantly and independently associated with the presence of NASH or severe fibrosis by logistic regression analysis.CONCLUSION: Both markers of liver fibrosis are useful in discriminating NASH from fatty liver alone or patients with severe fibrosis from patients with non-severe fibrosis. | Hiroshi Sakugawa Tomofumi Nakayoshi Kasen Kobashigawa Tsuyoshi Yamashiro Tatsuji Maeshiro Satoru Miyagi Joji Shiroma Akiyo Toyama Tomokuni Nakayoshi Fukunori Kinjo Atsushi Saito | 2005 | World Journal of Gastroenterology2005，11，2： | 9 |
| 16 | Analysis and Improvement of Authenticatable Ring Signcryption Scheme显示文摘We show that the Zhang-Yang-Zhu-Zhang identity-based authenticatable ring signcryption scheme is not secure against chosen plaintext attacks.Furthermore, we propose an improved scheme that remedies the weakness of the Zhang-Yang-Zhu-Zhang scheme.The improved scheme has shorter ciphertext size than the Zhang-Yang-Zhu-Zhang scheme.We then prove that the improved scheme satisfies confidentiality, unforgeability, anonymity and authenticatability. | 李发根 Shirase Masaaki Takagi Tsuyoshi | 2008 | Journal of Shanghai Jiaotong university(Science)2008，13，6： | 9 |
| 17 | Height growth, diameter-height relationships and branching architecture of Pinus massoniana and Cunninghamia lanceolata in early regeneration stages in Anhui Province, eastern China: effects of light intensity and regeneration mode显示文摘To determine the growth strategies during early regeneration stages of two major coniferous species (Pinus massoniana and Cunninghamia lanceolata) in a secondary mixed coniferous forest in the Huangshan region of Anhui Province, eastern China, we examined height growth, diameter-height relationship and the relationship between main stem and lateral branch elongation in saplings, with a particular focus on the effects of light intensity and regeneration mode (seedlings versus sprouts). When light intensity was sufficiently high, the extension growth of main stems was greater and more positively related to initial size for P. massoniana than for C. lanceolata. The slenderness of the stem form increased in the following order: C. lanceolata seedlings < P. massoniana seedlings < C. lanceolata sprouts. P. massoniana became less slender with increasing light intensity. P. massoniana had shorter branches than C. lanceolata given the same main stem elongation. Growth allocation depended more strongly on light intensity for P. massoniana than for C. lanceolata, with more growth allocated to the main stem under dark conditions. These results suggest that P. massoniana is a typical shade avoider; this species gives priority to extension growth of the main stem, especially when it is shaded. In contrast, C. lanceolata is a shade tolerator; this species allocates more biomass to radial growth of its main stems and to extension growth of branches. Based on these results, the ecological characteristics of P. massoniana and C. lanceolata and the roles of seedlings and sprouts are discussed in relation to stand dynamics of the mixed forests of P. massoniana and C. lanceolata in eastern China. | CHENG Xi-ping Umeki KIYOSH Honjo TSUYOSHI SHAO Peng-yue | 2011 | Forestry Studies in China2011，13，1： | 9 |
| 18 | An advanced partitioning process for key elements separation from high level liquid waste显示文摘To separate MA(Am,Cm) and some fission product elements(FPs) such as Tc,Pd,Cs and Sr from high level liquid waste(HLLW) systematically,we have been studying an advanced aqueous partitioning process,which uses selective adsorption as the separation method.For this process,we prepared several novel adsorbents which were immobilized in a porous silica/polymer composite support(SiO 2-P).Adsorption and separation behavior of various elements was studied experimentally in detail.Small scale separation tests using simulated HLLW solutions were carried out.Pd(II) was strongly adsorbed by the AR-01 anion exchanger and effectively eluted off by using thiourea.Successful separation of Pd(II) from simulated HLLW was achieved.Tc(VII) also exhibited strong adsorption on AR-01 and could be eluted off by using U(IV) as a reductive eluent.Am(III) presented significantly high adsorbability and selectivity onto R-BTP/SiO 2-P adsorbents over various FPs including Ln(III).The R-BTP adsorbents were fairly stable in 3 M HNO 3,but instable against-irradiation-3M HNO 3.An advanced partitioning process consisting of three separation columns for the target elements separation from HLLW was proposed and the obtained experiment results indicated that the proposed process is essentially feasible. | WEI YueZhou WANG XinPeng LIU RuiQin WU Yan USUDA Shigekazu ARAI Tsuyoshi | 2012 | Science China Chemistry2012，55，9： | 9 |
| 19 | Distribution of late gadolinium enhancement in various types of cardiomyopathies:Significance in differential diagnosis, clinical features and prognosis显示文摘The recent development of cardiac magnetic resonance(CMR)techniques has allowed detailed analyses of cardiac function and tissue characterization with high spatial resolution.We review characteristic CMR features in ischemic and non-ischemic cardiomyopathies(ICM and NICM),especially in terms of the location and distribution of late gadolinium enhancement(LGE).CMR in ICM shows segmental wall motion abnormalities or wall thinning in a particular coronary arterial territory,and the subendocardial or transmural LGE.LGE in NICM generally does not correspond to any particular coronary artery distribution and is located mostly in the mid-wall to subepicardial layer.The analysis of LGE distribution is valuable to differentiate NICM with diffusely impaired systolic function,including dilated cardiomyopathy,end-stage hypertrophic cardiomyopathy(HCM),cardiac sarcoidosis,and myocarditis,and those with diffuse left ventricular(LV)hypertrophy including HCM,cardiac amyloidosis and Anderson-Fabry disease.A transient low signal intensity LGE in regions of severe LV dysfunction is a particular feature of stress cardiomyopathy.In arrhythmogenic right ventricular cardiomyopathy/dysplasia,an enhancement of right ventricular(RV)wall with functional and morphological changes of RV becomes apparent.Finally,the analyses of LGE distribution have potentials to predict cardiac outcomes and response to treatments. | Hiroshi Satoh Makoto Sano Kenichiro Suwa Takeji Saitoh Mamoru Nobuhara Masao Saotome Tsuyoshi Urushida Hideki Katoh Hideharu Hayashi | 2014 | World Journal of Cardiology2014，6，7： | 8 |
| 20 | MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors显示文摘AIM:To clarify differences in mucin phenotype, prolif-erative activity and oncogenetic alteration among subtypes of colorectal laterally spreading tumor (LST). METHODS:LSTs, defined as superficial elevated lesions greater than 10 mm in diameter with a low vertical axis, were macroscopically classified into two subtypes:(1) a granular type (Gr-LST) composed of superficially spreading aggregates of nodules forming a flat-based lesion with a granulonodular and uneven surface; and (2) a non-granular type (NGr-LST) with a flat smooth surface and an absence of granulonodular formation. A total of 69 LSTs, comprising 36 Gr-LSTs and 33 NGr-LSTs, were immunohistochemically stained with MUC2, MUC5AC,MUC6, CD10 (markers of gastrointestinal cell lineage), p53, β-catenin and Ki-67 antibodies, and examined for alteration in exon 1 of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and exon 15 of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) by poly-merase chain reaction followed by direct sequencing. RESULTS:Histologically, 15 Gr-LST samples were adenomas with low-grade dysplasia (LGD), 12 were high-grade dysplasia (HGD) and 9 were adenocarcinomas invading the submucosa (INV), while 12 NGr-LSTs demonstrated LGD, 14 HGD and 7 INV. In the proximal colon, MUC5AC expression was significantly higher in the Gr-type than the NGr-type. MUC6 was expressed only in NGr-LST. MUC2 or CD10 did not differ. P53 expression demonstrated a significant stepwise increment in progression through LGD-HGD-INV with both types of LST. Nuclear β-catenin expression was significantly higher in the NGr-type. Ki-67 expression was signifi-cantly higher in the Gr-type in the lower one third zone of the tumor. In proximal, but not distal colon tumors, the incidence of KRAS provided mutation was signifi-cantly higher in the Gr-type harboring a specific mutational pattern (G12V). BRAF mutations (V600E) were detected only in two Gr-LSTs. CONCLUSION:The two subtypes of LST, especially in the proximal colon, have differing phenotypes of gastrointestinal cell lineage, proliferation and activation of Wnt/β-catenin or RAS/RAF/extracellular signal-regulated kinase signaling. | Kosaburo Nakae Hiroyuki Mitomi Tsuyoshi Saito Michiko Takahashi Takashi Morimoto Yasuhiro Hidaka Naoto Sakamoto Takashi Yao Sumio Watanabe | 2012 | World Journal of Gastroenterology2012，18，39： | 8 |
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