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	题名	作者	年代	出处	被引量
1	Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters.	V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun	2003	World Journal of Gastroenterology2003，9，10：	5
2	Levels of soluble intercellular adhesion molecule-land total sialic acid in serum of patients with laryngeal cancer 显示文摘	Akca YF Taysi S Uslu C	2001	Jpn J Clin Oncol2001，31，12：	1
3	Can serum CA125 levels predict the optimal primary cytoreduction in patients with advanced ovarian carcinoma?显示文摘	Saygili U Guclu S Uslu T	2002	Gynecol Oncol2002，86，1：	1
4	Can serum CA-125 levels predict the optimal primary cytoreduction in patients with advanced ovarian carcinoma显示文摘	Saygili U Gudu S Uslu T	2002	Gynecol Oncol2002，86，1：	1
5	Effects of two different regimensof continuous hormone replacement therapy on endometrialhistopathology and postmenopausal uterine bleeding显示文摘	Yildirin G Tugrul S Uslu H	2006	JAMA2006，273，5：	1
6	The evaluation of polycythemic newborns:efficacy of partial exchange transfusion显示文摘	Uslu S Ozdemir H Bulbul A	2011	J Matern Fetal Neonatal Med2011，24，12：	1
7	The determinants of right ventricular function in patients with atrial septal defect显示文摘	Gorgulu S Eren M Uslu N	2006	Int J Cardiol2006，111，：	1
8	The evaluation of the causes of subjective voice disturbances after thyroid surgery显示文摘	Soylu L Ozbas S Uslu HY	2007	The American Journal of Surgery2007，194，：	1
9	Longitudinal left ventricular systolic function is impaired in patients with coronary slow flow显示文摘	Nurkalem Z Gorgulu S Uslu N		0，，：	1
10	Effects of lipoprotein associated phospholipase A2 on arginase/nitric oxide pathway in hemodialysis patients显示文摘	Tektas AK Uslu S Yalcin AU	2012	Ren Fail2012，34，6：	1
11	Serum cystatin C and urina ry enzymes as screening markers of renal dysfunction in diabetic patients显示文摘	Uslu S Efe B Alatas O		J Nephrol0，18，5：	1
12	Changes in vascularity of cartilage endplate of degenerated intervertebral discs in response to melatonin administration in rats显示文摘	Uslu S Uysal A	2003	Neurosurg Rev2003，26，2：	1
13	Epidemiology of enterovirus 71 in the Netherlands, 1963 to 2008 显示文摘	Van der Sanden S Koopmans M Uslu G	2009	J Clin Microbiol2009，47，9：	1
14	Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus显示文摘	Uslu S Kebapci N Kara M	2012	Exp Ther Med2012，4，1：	1
15	Influence of training frequency on serum concentrations of some essential trace elements and e- lectrolytes in male swimmers 显示文摘	Doker S Hazar M Uslu M	2014	Biological trace element re- search2014，158，1：	1
16	Longitudinal left ventricular systolic function is impaired in patients with coronary slow flow显示文摘	Nurkalem Z Gorgulu S Uslu N		0，，01：	1
17	A comparative study foradsorptionof methylene blue &om aqueous solutions by twddnds of ambo'lite resinmaterials显示文摘	KERKEZ 0 BAYAZIT S USLU H	2012	Desalin Water Treat2012，45，：	1
18	Evaluation of the turkish ver- sion of the ' ages and stages questionnaires: social-emotional' in i- dentifying children with social-emotional problems显示文摘	UCUKER S KAPCI E G USLU R D	2011	Infants Young Child2011，24，2：	1
19	Equilibrium studies of extraction of levulinic acid by ( trioc, tylamine ( TOA ) + ester) solvents 显示文摘	Uslu H Kirbaslar S I	2008	Journal of Chemical & Engineering Data2008，53，7：	1
20	Longitudinal left ventrieular sys- tolic runetion is impaired in patients with corollary slow flow显示文摘	Nurkalem Z Gorgulu S Uslu N	2009	Int J Cardiovase Imaging2009，25，：	1

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