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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | The role and significance of Magnesium in modern day research-A review显示文摘Magnesium is one of the largely available elements in the earth’s crust. It has a low structural density with high specific strength. This unique material property has forced an increase in the use of magnesium and its alloys in various applications pertaining to industrial sector,automobiles, aerospace and biomedical. Since magnesium is a highly reactive metal, it is prone to higher rate of corrosion as compared to its counterparts. Thus, it is essential to analyze the corrosion behavior of magnesium and its alloys in its applications. An appropriate process is to be followed in the design and development of magnesium alloys which overcome the limitations of magnesium and enhance the desired material properties in accordance to their applications. This review paper summarizes the importance of magnesium and its material properties. The influence of various alloying elements on the mechanical properties of magnesium is reviewed. The broad classification of Mg alloys and their behavioral trends are detailed. The corrosion behavior of magnesium and the influence of corrosion products on the material characteristics of magnesium, in aqueous medium, are discussed. The manufacturing techniques of magnesium alloys along with the secondary techniques are also covered. The various applications and the limitations of magnesium in these applications are covered. A complete section is dedicated towards detailing the recent trends of magnesium(Mg) alloys, i.e., the biodegradable nature and applications of Mg alloys. The influence of biocorrosion on Mg alloys and techniques to overcome it have been deliberated. This paper provides a thorough review on recent developments of magnesium with respect to engineering applications. | S V Satya Prasad S B Prasad Kartikey Verma Raghvendra Kumar Mishra Vikas Kumar Subhash Singh | 2022 | Journal of Magnesium and Alloys2022，10，1： | 11 |
| 3 | Diffraction of elastic P waves by two equal co-axial circular rigid strips显示文摘 | Verma S K Jain D L | 1992 | European Journal of Mechanics A/Solids1992，11，2： | 2 |
| 4 | Discovery of Web services in a multi-ontology and federated registry environment显示文摘 | Oundhakar S Verma K Sivashanmugam K | 2005 | Int''l Journal of Web Services Research2005，2，3： | 1 |
| 5 | Protective effects of GSH, VE and selenium on lipid peroxidation in cadmium-fed rats显示文摘 | Rana SV Verma S | 1996 | Biol Trace ElementRes1996，51，： | 1 |
| 6 | A noval low-temperature synthesis of nanosized NiZn fetrite显示文摘 | Verma S Pradhan S D Pasricha R | 2005 | Journal of the American Chemical Society2005，88，： | 1 |
| 7 | Proline biosynthesis and osmoregulation in plants显示文摘 | Delauney A J Verma D P S | 1993 | The Plant Journal1993，4，2： | 1 |
| 8 | Evaluating and treating co - morbid pain and depression显示文摘 | Gallagher RM | 2000 | Intern rew of Psych2000，12，： | 1 |
| 9 | The T-786->C mutation in endothelial nitric oxide synthase is associated with hypertension显示文摘 | Parsons HG Verma S | 2002 | Hypertension2002，39，4： | 1 |
| 10 | Putrescine alleviation of growth in salt stressed Brassica juncea by inducing antioxidative defense system显示文摘 | Verma S Mishra S N | 2005 | Journd of Plant Physiology2005，162，6： | 1 |
| 11 | Hemorrhagic pleural effu- sion secondary to sarcoidosis:A brief review显示文摘 | Kumar S Verma SK Singh R Prasad R | 2009 | Ann Thorac Med2009，4，1： | 1 |
| 12 | Cardiac re-modeling and failure : from molecules to man ( Part 1 ) 显示文摘 | Fedak 1' W Verma S Weisel R D | 2005 | Cardiovasc: Pathol2005，14，： | 1 |
| 13 | Optimizing care of heart failure after acute MI with an aldosterone receptor antagonist显示文摘 | VERMA A SOLOMEN S D | 2007 | Curr Heart Fail Rep2007，4，4： | 1 |
| 14 | Pharmacological modulation of insulin resistance and hyperinsulinemia in polycystic ovary syndrome显示文摘 | Verma S Mather K Dumont AS | 1998 | The Endocrinologist1998，8，6： | 1 |
| 15 | Modified cellulosic nanofiltration membrane with improved characteristics for desalination and concentration of reactive dyes 显示文摘 | Venkidachalam G Verma S K | 1996 | Indian Journal of Chemical Technology1996，3，： | 1 |
| 16 | insulin resistance as a therapeutic target for improved endothelial function: metformin 显示文摘 | Brame L Verma S Anderson T | 2004 | Curt Drug Targets Cardiovasc Haematol Disord2004，4，1： | 1 |
| 17 | Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function显示文摘 | Hyndman E Verma S Rosenfeld RJ | 2002 | Am J Physiol Heart Circ Physiol2002，282，： | 1 |
| 18 | Crystallization behavior of nparaffins in Bombay-High middle-distillate wax/gel显示文摘 | Srivastava S P Tandon R S Verma P S | 1992 | Fuel1992，71，5： | 1 |
| 19 | Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein显示文摘 | Verma S Li SH Badiwala MV | 2002 | Circulation2002，105，16： | 1 |
| 20 | Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States 显示文摘 | Nair S Verma S Thuluvath PJ | 2002 | Hepatology2002，35，1： | 1 |
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