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| 1 | Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial显示文摘AIM:To evaluate the effect of resistance training(RT)on non alcoholic liver disease(NAFLD)patients.METHODS:A randomized clinical trial enrolling NAFLD patients without secondary liver disease(e.g.,without hepatitis B virus,hepatitis C virus or excessive alcohol consumption).Patients were randomly allocated either to RT,three times weekly,for 3 mo or a control arm consisting of home stretching.The RT included leg press,chest press,seated rowing,latissimus pull down etc.with 8-12 repetitions,3 sets for each exercise,for a total duration of 40 min.Hepatic ultrasound,fasting blood tests,anthropometrics and body composition by dual energy X-ray absorptiometry were assessed.At baseline and follow-up,patients filled out a detailed semi-quantitative food frequency questionnaire reporting their habitual nutritional intake.Steatosis was quantified by the hepatorenal-ultrasound index(HRI)representing the ratio between the brightness level of the liver and the right kidney.The HRI has been previously demonstrated to be highly reproducible and was validated against liver biopsy and proton magnetic resonance spectroscopy.RESULTS:Eighty two patients with primary NAFLD were randomized to receive 3 mo of either RT or stretching.After dropout or exclusion from analysis because of protocol violation(weight change>3 kg),thirty three patients in the RT arm and 31 in the stretching arm completed the study per protocol.All baseline characteristics were similar for the two treatment groups with respect to demographics,anthropometrics and body composition,blood tests and liver steatosis on imaging.HRI score was reduced significantly in the RT arm as compared to the stretching arm(-0.25±0.37 vs-0.05±0.28,P=0.017).The RT arm had a significantly higher reduction in total,trunk and android fat with increase in lean body mass.There was no correlation between the reduction in HRI in the RT arm and weight change during the study,but it was positively correlated with the change in trunk fat(r=0.37,P=0.048).The RT arm had a significant reduction in serum ferritin and total cholesterol.There was no significant difference between arms in dietary changes and these did not correlate with HRI change.CONCLUSION:Three months RT improves hepatic fat content accompanied by favorable changes in body composition and ferritin.RT may serve as a complement to treatment of NAFLD. | Shira Zelber-Sagi Assaf Buch Hanny Yeshua Nahum Vaisman Muriel Webb Gil Harari Ofer Kis Naomi Fliss-Isakov Elena Izkhakov Zamir Halpern Erwin Santo Ran Oren Oren Shibolet | 2014 | World Journal of Gastroenterology2014，20，15： | 17 |
| 2 | 人血浆硫氧化还原蛋白80随着年龄增长而增加,并在载脂蛋白E基因敲除小鼠中诱导炎症、血管生成和动脉粥样硬化显示文摘硫氧化还原蛋白(thioredoxin,TRX)1是一种普遍存在的12kD的蛋白质,可产生抗氧化和抗炎作用。由巨噬细胞产生的截断形式称为TRX80,其可诱导促炎细胞因子的上调。TRX80还促进小鼠腹膜和人巨噬细胞向促炎M1表型的分化。方法:使用特异性酶联免疫吸附试验测定血浆TRX1和TRX80水平。 | 刘莉 叶鹏 Couchie D Vaisman B Abderrazak A Mahmood DFD Hamza MM Canesi F Diderot V El Hadri K Nègre-Salvayre AE Le Page A Fulop T Remaley AT Rouis M | 2017 | 中华高血压杂志2017，25，6： | 9 |
| 3 | Central- to- peripheral fat ratio, but not peripheral body fat, is related to insulin resistance and androgen markers in polycystic ovary syndrome显示文摘 | Godoy- Matos AF Vaisman F Pedrosa AP | 2009 | Gynecol Endocrinol2009，25，12： | 1 |
| 4 | Lecithin: cholesterol acyltrans- ferase-from biochemistry to role in cardiovascular disease 显示文摘 | Rousset X Vaisman B Amar M | 2009 | Curr Opin Endocrinol Diabetes Obes2009，16，2： | 1 |
| 5 | Prevalence of goiter and thyroid nodular disease in patients with class It/ obesity显示文摘 | de Sousa PAM Vaisman M Carneiro JRL | 2013 | Arq Bras Endocrinol Metab2013，57，2： | 1 |
| 6 | Energy metabolism in children with newly diagnosed acute lymphoblastic leukemia显示文摘 | Stallings VA Vaisman N Chan HS | 1989 | Pediatr Res1989，26，： | 1 |
| 7 | ABCA1 over expression leads to hyperal phalipoproteinemia and increased biliary cholesterol excretion in transgenic mice显示文摘 | Vaisman BL Lambert G Amar M | 2001 | Clin Invest2001，108，2： | 1 |
| 8 | ABCA1 over expression leads to hyperalphalipoproteinemia and increased biliary cholesterd excretion in transgenimic mice 显示文摘 | Vaisman BL Lambert G Amar M | 2001 | J Clin Invest2001，108，2： | 1 |
| 9 | Thyroid function tests in viral chronic hepatitis 显示文摘 | Novis M Vaisman M Coelho HS | 2001 | Arq Gastroenterol2001，38，4： | 1 |
| 10 | Polymer-nanoinclusion interactions in carbon nanotube based polyaerylonitrile extruded and electrospun fibers显示文摘 | Vaisman L Larin B Davidi I | 2007 | Polymer2007，48，23： | 1 |
| 11 | The role of surfactants in dispersion of carbon nanotubes 显示文摘 | Vaisman L Wagner H D Marom G | 2006 | Advances in Colloid and Interface Science2006，126，3： | 1 |
| 12 | 显示文摘 | Amar MJ Vaisman BL Paigent B | 1997 | Circulation1997，96，： | 1 |
| 13 | Long- term follow-up of patients with differentiated thyroid cancer who had negative 1311 whole-body scan at first evaluation after treatment显示文摘 | Caminha LS Momesso DP Vaisman F | | C/in Nucl Med0，38，10： | 1 |
| 14 | ABCA1 over-expression leads to hyper-alpha-lipoproteinemia and increased biliary cholesterol excretion in transgenic mice显示文摘 | Vaisman BL Lambert G Amar M | 2001 | J Clin Invest2001，108，2： | 1 |
| 15 | Enteral Feeding Enriched with Carotenoids Normalizes the Carotenoid Status and Reduces Oxidative Stress in Long-Term Enterally Fed Patients显示文摘 | VAISMAN N HAENEN G R M ZARUK Y | 2006 | Clinical Nutrition2006，25，6： | 1 |
| 16 | Is it necessary to increase the dose of levothyroxine in patients with hypothyroidism who use omeprazole? 显示文摘 | Abi-Abib RC Vaisman M | 2014 | Arq Bras Endocrinol Metabol2014，58，7： | 1 |
| 17 | A subclass of tumor-inhibi- tory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors 显示文摘 | Klapper LN Vaisman N Hurwitz E | 1997 | Oncogene1997，14，17： | 1 |
| 18 | Cell cycle changes associated with formation of Pt-DNA adducts in human ovarian carcinoma cells with different cisplatin sensitivity显示文摘 | Vaisman A Varchenko M Said I Chaney SG | 1997 | Cytometry1997，27，1： | 1 |
| 19 | Tumour re-differentiation effect of retinoic acid:a novel therapeutic approach for advanced thyroid cancer显示文摘 | Coelho SM Vaisman M Carvalho DP | 2005 | Curr Pharm Des2005，11，19： | 1 |
| 20 | Characterization of the mangrove oyster, Crassostrea rhizophorae, as a biomonitor formercury in tropical estuarine systems, Northeast Brazil 显示文摘 | Vaisman A G Marins R V Lacerda L D | 2005 | Bulletin of Environmental Contamination and Toxicology2005，74，3： | 1 |
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