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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
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| 14 | Type II meta- caspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave suhstrates after arginine and lysine显示文摘 | VERCAMMEN D VAN DE COTTE B DE JAEGER G l | 2004 | J Biol Chem2004，279，45： | 1 |
| 15 | EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal,reactive and malignant leukocytes显示文摘 | van Dongen JJ Lhermitte L B(o)ttcher S | 2012 | Leukemia2012，26，： | 1 |
| 16 | Catalytic mechanism and product specificity of cyclodextrin glycosyltransferase,a prototypical trans-glycosylase from theα-amylase显示文摘 | Uitdehaag J C M van der Veen B A Dijkhuizen L | 2002 | Enzyme and Microbial Technology2002，30，3： | 1 |
| 17 | UV-Vis microspectroscopy: Probing the initial stages of supported metal oxide catalyst preparation显示文摘 | VAN DE WATER L G A BERGWERFF J A NIJHUIS T A DE JONG K P WECKHUYSEN B M | 2005 | J Am Chem Soc2005，127，14： | 1 |
| 18 | Creative Accounting or Creative Destruction?Firm-level Productivity Growth in Chinese Manufacturing显示文摘 | Brandt L Van B J Zhang Y F | 2012 | Journal of Development Economics2012，97，33： | 1 |
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| 20 | The inhibition of growth or cell division in Escherichia coli by different ionic species of platinum(Ⅳ) complexes显示文摘 | Rosenberg B Van Camp L Grimley EB | 1967 | J Biol Chem1967，242，： | 1 |
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