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| 1 | Effect of Tiantai No.1 (天泰1号) on β-Amyloid-induced Neurotoxicity and NF-κ B and cAMP Responsive Element-binding Protein显示文摘Objective:To investigate the effect and molecular mechanism of Tiantai No.1(天泰1号),a compound Chinese herbal preparation,for the prevention and reduction of neurotoxicity induced by beta- amyloid peptides(Abeta)in vitro and its effects on nuclear factor-κB(NF-κB)and cAMP responsive element-binding protein(CREB)pathways using the gene transfection technique.Methods:B104 neuronal cells were used to examine the effects of Tiantai No.1 on lowering the neurotoxicity induced by Abeta.The cells were pre-treated with Tiantai No.1 at doses of 50,100,150,or 200μg/mL respectively for 3 days and co-treated with Tiantai No.1 and beta-amyloid peptidel-40(Aβ1-40,10μmol/L)for 48 h or post- treated with Tiantai No.1 for 48 h after the cells were exposed to beta-amyloid peptides25-35(Aβ25-35) for 8 h.In gene transfection assays,cells were treated with Tiantai No.1 at 50μg/mL and 150μg/mL for 5 days or co-treated with Tiantai No.1 and Aβ1-40(5μmo/L)for 3 days after electroporation for the evaluation of NF-κB and CREB expression.Results:Pre-treating and co-treating B104 neuronal cells with Tiantai No.1 lowered the neurotoxicity induced by Abeta,and post-treating with Tiantai No.1 reduced or blocked B104 neuronal apoptotic death induced by Abeta(P<0.05,P<0.01).With a dose-dependent relationship,the same treatments increased the expression of NF-κB or CREB in B104 neuronal cells (P<0.05,P<0.01).Meanwhile,Tiantai No.1 reduced Aβ-40 induced inhibition on NF-κB expression (P<0.01).Conclusions:Tiantai No.1 can protect neurons against the neurotoxicity induced by Abeta.The neuroprotective mechanisms may be associated with the activation of NF-κB and cAMP cellular signal pathways. | 吴正治 Andrew C.J.Huang Jean de Vellis 李映红 | 2008 | Chinese Journal of Integrative Medicine2008，14，4： | 4 |
| 2 | 心脏骤停后DTI(弥散张量成像)与神经学预后的关系心脏骤停后DTI(弥散张量成像)与神经学预后的关系显示文摘通过计算FA的值,大脑MRI的弥散张量成像技术可以定量失语患者的大脑白质损伤情况,这项研究对心脏骤停后昏迷7天患者的FA值实用意义进行评估。这项多中心队列研究纳入了185名在心脏骤停后意识不清7天的患者。每个患者评估入院时及七天内的GCS评分,7天内以及心脏骤停28天后的头颅MRI检查,以及恢复自主循环后72小时内的脑电图。 | 李建华 Velly L Perlbarg V Boulier T | 2018 | 中国康复2018，33，4： | 4 |
| 3 | Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters 显示文摘 | Velly LJ Guillet BA Masmejean FM Nieoullon AL Bruder NJ Gouin FM | 2003 | Anesthesiolo- gy2003，99，2： | 1 |
| 4 | Expression and functional role of the Id HLH family in cultured astrocytes 显示文摘 | Tzeng SF de Vellis J | 1997 | Brain Res Mol Brain Res1997，46，12： | 1 |
| 5 | Neuroprotective effects of propofol in a model of ischemic cortical cell cultures:role of glutamate and its transporters显示文摘 | Velly LJ Guillet BA Masmejean FM | 2003 | Anesthesiology2003，99，2： | 1 |
| 6 | Preparation of separate astroglial and oligodendroglia cell cultures from rat cerebral tissue显示文摘 | McCarthy KD De Vellis J | 1980 | J Cell Biol1980，85，3： | 1 |
| 7 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue显示文摘 | De Vellis J | 1980 | J Cell Biol1980，85，： | 1 |
| 8 | Sevoflurane pre- conditioning against focal cerebral ischemia: inhibition of apoptosis in the face of transient improvement of neurological outcome 显示文摘 | Codaccioni JL Velly LJ Moubarik C | 2009 | Anesthesiology2009，110，6： | 1 |
| 9 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue显示文摘 | McCarthy KD de Vellis J | 1980 | J Cell Biol1980，85，3： | 1 |
| 10 | Microglia in health and disease显示文摘 | Kim SU de Vellis J | 2005 | J Neurosci Res2005，81，3： | 1 |
| 11 | The effect of catastrophizing and depression on chronic pain-a prospective cohortstudy of temporomandibular muscle and joint pain disorders 显示文摘 | Velly AM Look JO Carlson C | 2011 | PAIN2011，152，： | 1 |
| 12 | Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growth显示文摘 | Ghiani CA Ying Z de Vellis J | 2007 | Glia2007，55，9： | 1 |
| 13 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue 显示文摘 | McCarthy K D De Vellis J | 1980 | J Cell Biol1980，85，： | 1 |
| 14 | Differential regulation by pro- tein kinases of activity and cell surface expression of glutamate trans- porters in neuron-enriched cultures 显示文摘 | Guillet BA Velly LJ Canolle B | 2005 | Neurochem Int2005，46，： | 1 |
| 15 | Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture 显示文摘 | MORRISON R S SHARMA A de VELLIs J | 1986 | ProC Natl Acad SCi USA1986，83，： | 1 |
| 16 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue 显示文摘 | McCarthy KD De Vellis J | 1980 | J Cell Biol1980，85，3： | 1 |
| 17 | Sevoflurane precon- ditioning against focal cerebral ischemia: inhibition of apoptosis in the face of transient improvement of neurological outcome 显示文摘 | Codaccioni JL Velly LJ Moubarik C | 2009 | Anesthesiology2009，110，6： | 1 |
| 18 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue 显示文摘 | McCarthy K D J de Vellis | 1980 | J Cell Bio1980，85，3： | 1 |
| 19 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue显示文摘 | Mccarthy KD De Vellis J | 1980 | J Cell Bio11980，85，3： | 1 |
| 20 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue 显示文摘 | McCarthy KD de Vellis J | 1980 | J Cell Biol1980，85，3： | 1 |
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