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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | Solidification microstructure and M2C carbine decomposition in a spray-formed high-speed steel显示文摘 | Lee E Park W Jung J Y Ahn S | 1998 | Metallurgical and Materials Transactions A1998，29，： | 2 |
| 4 | Polaronic transport properties in La1-x Srx FeO3 system 显示文摘 | JUNG W H IGUCHI E | 1995 | J Phys:Condens Matter1995，7，： | 2 |
| 5 | Preslaughter diet management in sheep and goats:effects on physiological responses and microbial loads on skin and carcass显示文摘Sixteen crossbred buck goats(Kiko x Spanish;BW = 32.8 kg) and wether sheep(Dorset x Suffolk;BW = 39.9 kg) were used to determine the effect of preslaughter diet and feed deprivation time(FDT) on physiological responses and microbial loads on skin and carcasses.Experimental animals were fed either a concentrate(CD) or a hay diet(HD)for 4 d and then deprived of feed for either 12-h or 24-h before slaughter.Blood samples were collected for plasma Cortisol and blood metabolite analyses.Longisimus muscle(LM) pH was measured.Skin and carcass swabs were obtained to assess microbial loads.Plasma creatine kinase activity(863.9 and 571.7 ± 95.21 IU) and non-esterified fatty acid concentrations(1,056.1 and 589.8 + 105.01 mEq/L) were different(P< 0.05) between sheep and goats.Species and diet treatments had significant effects on the ultimate pH of LM.Pre-holding total coliform(TCC) and aerobic plate counts(APC) of skin were significantly different between species.Goats had lower(P < 0.05) TCC(2.1 vs.3.0 log_(10) CFU/cm^2) and APC(8.2 vs.8.5 log_(10) CFU/cm^2) counts in the skin compared to sheep.Preslaughter skin E.coli counts and TCC were different(P < 0.05) between species.Goats had lower(P < 0.05) counts of E.coli(2.2 vs.2.9 log_(10) CFU/cm^2) and TCC(2.3 vs.3.0 log_(10) CFU/cm^2) in the skin compared with those in sheep.Diet,species,and FDT had no effect(P> 0.05) on E.coli and TCC in carcass swab samples.The APC of carcass swab samples were only affected(P < 0.05) by the FDT.The results indicated that preslaughter dietary management had no significant changes on hormone and blood metabolite concentrations and sheep might be more prone for fecal contamination than goats in the holding pens at abattoir. | Govind Kannan Venkat R Gutta Jung Hoon Lee Brou Kouakou Will R Getz George W McCommon | 2015 | Journal of Animal Science and Biotechnology2015，6，1： | 2 |
| 6 | Discovery of genes for ginsenoside biosynthesis by analysis of ginseng expressed sequence tags显示文摘 | Jung J D Park H W Hahn Y- | 2003 | Plant Cell Rep2003，22，3： | 1 |
| 7 | Solidification microstructure and M2C carbide decomposition in a spray-formed high speed steel显示文摘 | LEE E PARK W JUNG J Y | 1998 | Metallurgical and Materials Transactions1998，29，5： | 1 |
| 8 | Anti-CD16/CD30 bispecific antibody treatment for Hodgkin's disease: role of infusion schedule and costimulation with cytokines 显示文摘 | Hartmann F Renner C Jung W ET aI | 2001 | Clinical Cancer Research2001，7，7： | 1 |
| 9 | Type studies on Phellinus baumii and Phellinus linte us 显示文摘 | LIM Y W LEE J S JUNG H S | 2003 | Mycotaxon2003，，85： | 1 |
| 10 | Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, Crassostrea gigas against free radical induced DNA damage显示文摘 | QIAN Z J JUNG W K BYUN H G | 2008 | Bioresouree Technology2008，99，9： | 1 |
| 11 | Deposition behavior of corrosion products on the zircaloy heat transfer surface显示文摘 | YEON J W JUNG Y J PYUN S | 2006 | Journal of Nuclear Materials2006，，354： | 1 |
| 12 | Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin, Rana catesbeiana Shaw显示文摘 | Qian Z J Jung W K Kim S K | 2008 | Bioresource Technology2008，99，6： | 1 |
| 13 | Prediction of collapse in femoral head osteonecrosis:a modified Kerboul method with use of magnetic resonance images显示文摘 | HA Y C JUNG W H KIM J R | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
| 14 | The neuroprotective effects of the seeds of Cassia obtusifolia on transient cerebral global ischemia in mice 显示文摘 | Kim D H Kim S Jung W Y | 2009 | Food Chem Toxicol2009，47，7： | 1 |
| 15 | DNA copy number aherations and expression of relevant genes in triple-negative breast cancer 显示文摘 | Han W Jung EM Cho J | 2008 | Genes Chromosomes Cancer2008，47，6： | 1 |
| 16 | Speed control of a permanent magnet synchronous motor with a torque observer: a fuzzy approach显示文摘 | Jung J W Kim T H Choi H H | 2010 | IET Control Theory and Applications2010，4，12： | 1 |
| 17 | Compact ultra - wideband printed antenna with band-rejection characteristic 显示文摘 | Choi W Chung K Jung J | 2005 | Electronic letters2005，41，18： | 1 |
| 18 | Pediatric pineal tumors: need for a drect surgical approach and compilcations of the occiptal transtentorial approch显示文摘 | SHIN H J CHO B K JUNG H W | 1998 | Childs Nerv Syst1998，14，： | 1 |
| 19 | Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo显示文摘 | Jung R Kruger W Hosch S | 1998 | Br J Cancer1998，78，9： | 1 |
| 20 | The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer显示文摘 | Ahmad SA Liu W Jung YD | 2001 | Cancer Res2001，61，4： | 1 |
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