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| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | 高级别胶质瘤的治疗反应评价标准显示文摘胶质瘤是最常见的颅内原发肿瘤,年发病率约为4/10万~5/10万。高级别胶质瘤预后差,胶质母细胞瘤的中位总生存期为14.4个月。随着影像学技术的不断发展,对于神经肿瘤的治疗反应评价标准也在不断更新。上世纪90年代CT开始大规模应用于临床,由Macdonald等提出了基于CT扫描的高级别胶质瘤治疗反应评价标准, | 李文斌 康勋 张红梅 陈建新 Wen Patrick Y 江涛 | 2017 | 中华神经外科杂志2017，33，3： | 11 |
| 3 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 4 | Regulation of Nrf2- and AP-l-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells显示文摘 | Sujit NAIR Avantika BARVE Tin-Oo KHOR Guo-xiang SHEN Wen LIN Jefferson Y CHAN Li CAI Ah-Ng KONG | 2010 | Acta Pharmacologica Sinica2010，31，9： | 5 |
| 5 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 6 | PFEM Formalism in Kronecker Notation 显示文摘 | Zhang Y M Wen B C Chen S H | 1996 | Mathematics and Mechanics of Solids1996，1，4： | 2 |
| 7 | Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage显示文摘 | Wen R Cheng T Li Y | 1996 | J Neurosci1996，16，19： | 2 |
| 8 | First Passage of Uncertain Single Degree-of-Freedom Nonlinear Oscillators显示文摘 | Zhang Y M Wen B C Liu Q L | 1998 | Computer Methods in Applied Mechanics and Engineering1998，165，4： | 2 |
| 9 | Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine显示文摘 | Manome Y Kunieda T Wen P Y | 1998 | Hum Gene Ther1998，，： | 2 |
| 10 | Processing of biocompatible porous Ti and Mg显示文摘 | WEN C E MABUCHI M Yamada Y | 2001 | Scripta Materialia2001，45，10： | 1 |
| 11 | Taurine modulates calcium influx through L-type voltage-gated calcium channels in isolated cochlear outer hair cells in guinea pigs 显示文摘 | Liu HY Gao W'Y Wen W | 2006 | Neurosci Lett2006，399，12： | 1 |
| 12 | First passage of uncertain single degree-of-freedom nonlinear oscillators显示文摘 | Wen B C Liu Q L | 1998 | Computer Methods in Applied Mechanics and Engineering1998，165，4： | 1 |
| 13 | Practical reliability-based design of gear pairs 显示文摘 | Liu Q L Wen B C | 2003 | Mechanism and Machine Theory2003，38，12： | 1 |
| 14 | Analysis of a high-order iterative learning control algorithm for uncertain nonlinear systems with state delays显示文摘 | CHEN Y GONG Z WEN C | 1998 | Automatic1998，34，3： | 1 |
| 15 | A 3-D transformation to improve the legibility of license plate numbers显示文摘 | Wen C Y Yu C C | 2002 | Journal of Forensic Sciences2002，47，3： | 1 |
| 16 | Effect of pore structure on Ni catalyst for CO2 reforming of CH4显示文摘 | SUN N WEN X WANG F WEI W SUN Y | 2010 | Energy Environ Sci2010，3，3： | 1 |
| 17 | Effect of bore liquid temperature and dope concentration on mechanical properties 显示文摘 | DA G Y WEN L C YANG B | 2006 | Separation and Purication Technology2006，51，： | 1 |
| 18 | Reliability analysis for rotor rubbing 显示文摘 | Zhang Y M Wen B C Leung Y T | 2002 | ASME Journal for Vibration and Acoustics2002，124，1： | 1 |
| 19 | Analysis and design of impulsive control systems 显示文摘 | Li Z G Wen C Y Soh Y C | 2001 | IEEE Trans Automat Contr2001，46，6： | 1 |
| 20 | Fuzzy states as a basis for a theory of fuzzy reliability显示文摘 | Cai K Y Wen C Y Zhang M L | 1993 | Microelectronics and Reliability1993，33，15： | 1 |
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