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| 1 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 2 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 3 | Germination of Kochia americana in relation to salinity显示文摘 | CLARKE L D WEST N E | | 0，，04： | 1 |
| 4 | Mapping surface soil organic carbon for crop fields with remote sensing 显示文摘 | CHEN F KISSEL D E WEST L T | 2005 | Journal of Soil And Water Conservation2005，60，1： | 1 |
| 5 | The impact of environmental interpretation in developing a connection to nature in park Visitors显示文摘 | BURBACH M E PENNISI L WEST C D | 2012 | LARNet-The Cyber Journal of Applied Leisure and Recreation Research2012，，： | 1 |
| 6 | Processing materials with microwave energy显示文摘 | Clark D E Folz D C West J K | 2000 | Materials Science & Engineering2000，287，： | 1 |
| 7 | Endothelial cell protection against ischemia/reperfusion injury by lecithinized superoxide dismutase显示文摘 | Koo D D Welsh K L West N E | 2001 | Kidney International2001，60，： | 1 |
| 8 | Preferential flow and pedotransfer functions for transport properties in sandy Kandiudults 显示文摘 | Shaw J N West L T Radcliffe D E | 2000 | Soil Science Society America Journal2000，64，： | 1 |
| 9 | Tumour-infihra- ting FOXP3 ( + ) lymphocytes are associated with cytotox- ic immune responses and good clinical outcome in oestro- gen receptor-negative breast cancer 显示文摘 | West N R Kost S E Martin S D | 2013 | Br J Cancer2013，108，1： | 1 |
| 10 | Model of risk of cortical cataract in the US population with exposure to increased ultraviolet radiation due to stratospheric ozone depletion 显示文摘 | West S K Longstreth J D Munoz B E | 2005 | Am J Epidemiol2005，162，11： | 1 |
| 11 | Microphytic crust influence on interrill erosion and infiltration capacity显示文摘 | Williams J D Dobrowolski J P West N E | 1995 | Transactions of the American Society of Agricultural Engineers1995，38，1： | 1 |
| 12 | Fractal dimension as a characterization of free volume created during fracture in brittle materials显示文摘 | MECHOLSKY J J WEST J K PASOJA D E | 2002 | Phlosophical Magazine A2002，82，1718： | 1 |
| 13 | Leaving nursing An event -history analysis of nurses' career 显示文摘 | Barron D West E | 2005 | Journal of Health Services Research Policy2005，10，3： | 1 |
| 14 | Computational thermodynamic modelling of direct to blister copper smelting显示文摘 | SW1NBOURNE D R WEST R C REED M E SHEERAN A | 2011 | Mineral Processing and ExtractiveMetallurgy2011，120，1： | 1 |
| 15 | Shikimate accumulation in sunflower, wheat and proso millet after glypho- sate application 显示文摘 | Henry E B Shaner D L West M S | 2007 | Weed Sci2007，55，： | 1 |
| 16 | Effects of initial graft tension on knee stability after anterior cruciate ligament reconstruction using hamstring tendons: A cadaver study 显示文摘 | Boylan D Greis P E West J R | 2003 | Arthroscopy2003，19，7： | 1 |
| 17 | Microphytic crust influence on wind erosion显示文摘 | Williams J D Dobrowolski J P West N E | 1995 | Transactions of the American Society of Agricultural Engineers1995，38，1： | 1 |
| 18 | Association of porcine circovirus 2 with reproductive failure in pigs: a retrospective study,1995 - 1998 显示文摘 | Bogdan J West K Clark E Konoby C Haines D Allan G McNeilly F Meehan B Krakowka S Ellis JA | 2001 | Can Vet J2001，42，7： | 1 |
| 19 | Preferential flow and Pedotransfer functions for transport properties in sandy Kandiudults显示文摘 | Shaw J N West L T Radcliffe D E | 2000 | Soil Science Society America Journal2000，64，： | 1 |
| 20 | Effects of salinity on germination, growth and yield of cowpea显示文摘 | Wests D W Francois L E | 1983 | Irrig Sci1983，，3： | 1 |
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