|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 3 | ISAR成像快速最小熵相位补偿方法显示文摘针对逆合成孔径雷达(ISAR)成像,该文提出一种快速运动补偿算法,该算法基于二维图像熵,并通过相位补偿的快速迭代,使图像熵逐渐达到最小,从而实现雷达像的自聚焦.实测数据处理结果表明,同现有方法相比,该方法不仅保证熵意义上的最佳聚焦效果,而且还具有较高收敛速度。 | 邱晓晖 Heng Wang Cheng Alice Yeo Siew Yam | 2004 | 电子与信息学报2004，26，10： | 11 |
| 4 | Dietary overlap of snow leopard and other carnivores in the Pamirs of Northwestern China显示文摘Information about competition between carnivore species for food within high altitude regions is limited.Data collected from the Taxkorgan Nature Reserve,China revealed important interactions between snow leopard(Panthera uncia),grey wolf(Canis lupus),red fox(Vulpes vulpes)and their prey species,including domestic livestock.Sixty-four line transects were conducted in order to identify field signs of habitat occupancy and collect scats for diet analysis.High dietary overlap was observed between all three carnivore species:snow leopard and red fox(Pianka’s index=0.96),red fox and grey wolf(Pianka’s index=0.90),snow leopard and grey wolf(Pianka’s index=0.87).Snow leopard and grey wolf showed significant predation on livestock(36.8%for snow leopard and 29.4%for grey wolf in diet composition).As a pioneering exploration of the endangered snow leopard and its relationship with other species within the alpine ecosystem under livestock grazing pressure,this study contributes a greater understanding of the relationship within carnivore guild in the Pamirs whilst providing implications for conservation planning and project implementation activities in China. | Jun Wang Alice Laguardia Peter John Damerell Philip Riordan Kun Shi | 2014 | Chinese Science Bulletin2014，59，25： | 8 |
| 5 | Advances in endovascular aneurysm management: coiling and adjunctive devices显示文摘Endovascular coil embolisation continues to evolve and remains a valid modality in managing ruptured and unruptured cerebral aneurysms.Technological advances in coil properties,adjunctive devices and interventional techniques continue to improve long-term aneurysm occlusion rates.This review elaborates on the latest advances in next-generation endovascular coils and adjunctive coiling techniques for treating cerebral aneurysms. | Jessica K Campos Brian V Lien Alice S Wang Li-Mei Lin | 2020 | Stroke & Vascular Neurology2020，5，1： | 5 |
| 6 | ISAR成像最小熵自聚焦与相位补偿的一致性分析显示文摘该文对ISAR成像的最小熵自聚焦(Minimum Entropy Auto-focusing,MEA)与相位补偿之间的一致性问题进行深入研究,文中的数学推导证明了对于ISAR距离-多普勒成像,相位补偿后的剩余相位误差为0时的相位补偿量不一定是ISAR图像熵函数的极小点,这与ISAR成像目标有关。仿真实验也表明使ISAR图像熵最小时的相位补偿剩余相位误差却未必为0,只有当目标本身的图像熵不大于任何非零剩余相位误差所对应的成像结果的熵时,ISAR成像的最小熵自聚焦才与相位补偿一致。 | 邱晓晖 赵阳 Alice Heng Wang CHENG Siew-Yam Yeo | 2007 | 电子与信息学报2007，29，8： | 5 |
| 7 | Fecal microbial transplant for the treatment of pediatric inflammatory bowel disease显示文摘The role of fecal microbial transplant(FMT) in the treatment of pediatric gastrointestinal disease has become increasingly popular among pediatric practitioners, patients, and parents. The success of FMT for the treatment of recurrent Clostridium difficile infection(RCDI) has bolstered interest in its potential application to other disease states, such as inflammatory bowel disease(IBD). FMT has particular interest in pediatrics, given the concerns of patients and parents about rates of adverse events with existing therapeutic options, and the greater cumulative medication burden associated with childhoodonset disease. Published literature on the use of FMT in pediatrics is sparse. Only 45 pediatric patients treated for RCDI have been reported, and only 27 pediatric patients with pediatric IBD. The pediatric microbiome may uniquely respond to microbial-based therapies. This review will provide a comprehensive overview of fecal microbial transplant and its potential role in the treatment of pediatric inflammatory bowel disease. We will discuss the microbiome in pediatric inflammatory bowel disease, existing adult and pediatric literature on the use of FMT in IBD treatment, and pediatric FMT trials that are currently recruiting patients. This review will also discuss features of the microbiome that may be associated with host response in fecal transplant, and potential challenges and opportunities for the future of FMT in pediatric IBD treatment. | Alice Yuxin Wang Jelena Popov Nikhil Pai | 2016 | World Journal of Gastroenterology2016，22，47： | 4 |
| 8 | 中国大陆居民对中风的危险因素、征兆、应急处理及信息获取等相关认知的调查研究(英文)显示文摘目的:以中国大陆居民为受访对象,就中风的认知和预防进行问卷调查,以推进预防中风的健康教育活动。方法:选择大陆两个主要城市(武汉和成都)公园、商场及其他公共场所的居民为对象,进行一项有关中风知识标准化的横截面问卷调查,内容包括风险因素、征兆、应急救援和信息获取。结果:846人参与问卷调查,其中55%为男性,45%为女性,平均年龄45.7岁。收集数据表明,28%的受调查居民认为高血压是主要的危险因素,头晕(29%)和麻木(20.2%)是中风常见的征兆。所有数据都显示,当中风时人们采取急救措施是有必要的。家庭/朋友(21%)及媒体(电视占19.5%,报纸占17.7%)是中风信息传播的主要途径。结论:应重视推广中国大陆地区有关中风预防的低成本高效率的教育项目,尤其是中风危险因素、征兆、应急处理和信息获取途径的相关项目。开拓多元化的途径,包括开展促进公众健康的活动,通过医疗专家和医疗设施开展健康教育活动向广大民众宣传中风常识和预防措施。 | Zhenyi LI Peng WANG Alice Y M JONES Elizabeth DEAN | 2015 | 康复学报2015，0，2： | 3 |
| 9 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 10 | Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma显示文摘Background:Exercise is widely known to lower intraocular pressure and increase ocular blood flow,which may be beneficial for glaucoma management.However,there are few studies that have reported on the relationship between exercise and glaucoma progression.The aim of our study was to investigate the exercise habits of those with primary open angle glaucoma(POAG)and its association with the progression of visual field(VF)loss.Methods:Daily physical activity(PA)was monitored by an accelerometer(ActiGraph wGT3x-BT)which patients wore for more than 10 h of being awake on their right wrists for 1 week.Results:Seventy-one non-progressive and 27 progressive patients were enrolled in the study.24-h moderate to vigorous physical activity(MVPA)exercise showed that POAG patients had similar variation trends consisting of 3 wave peaks and 2 wave hollows.Minutes spent in MVPA was 19.89±15.81 and 21.62±15.10 during 07:00–09:00 h(p=0.204),15.40±14.49 and 15.67±12.43 during 15:00–17:00 h(p=0.822)and 17.26±21.11 and 11.42±11.58 during 18:00–20:00 h(p=0.001)in the non-progressive and progressive group,respectively.Univariate analysis indicated that 10 min of MVPA(18:00–20:00 h)[odds ratio,OR(95%CI)=0.82(0.73,0.92)],average mean arterial pressure[OR(95%CI)=0.96(0.94,0.98)],age[OR(95%CI)=1.06(1.03,1.08)],male[OR(95%CI)=0.67(0.48,0.96)],spherical equivalent[OR(95%CI)=1.14(1.07,1.22)]and IOP-lowering medications[OR(95%CI)=1.54(1.16,2.05)]were significantly correlated with having progressive VF damage.Multivariable analysis showed that 10 min of MVPA(18:00–20:00 h)[OR(95%CI)=0.85(0.75,0.97)]was associated with progressive VF loss even after adjusting for other risk factors.Conclusions:Evening exercise may lower the odds of VF progression,suggesting that exercise habits possibly play an important role in glaucoma progression. | Xiafei Pan Kai Xu Xin Wang Guofu Chen Huanhuan Cheng Alice Jia Liu Laurence Tang Hou Lin Zhong Jie Chen Yuanbo Liang | 2020 | Eye and Vision2020，7，1： | 2 |
| 11 | Use of Emergency Medical Service Transport Among Patients With ST-Segment–Elevation Myocardial Infarction: Findings From the National Cardiovascular Data Registry Acute Coronary Treatment Intervention Outcomes Network Registry–Get With the Guidelines显示文摘 | Robin Mathews Eric D. Peterson Shuang Li Matthew T. Roe Seth W. Glickman Stephen D. Wiviott Jorge F. Saucedo Elliott M. Antman Alice K. Jacobs Tracy Y. Wang | 2011 | Circulation2011，，2： | 1 |
| 12 | Establishment of customized mouse stem cell lines by sequential nuclear transfer显示文摘治疗学的克隆,胚胎的干细胞(转换字符) 由此从原子转移(NT ) 被导出胚胎,可以在再生药的新时代起一个主要作用。Inthis 学习我们建立了四十原子转移 -- 从不同施主房间类型或段落的 NTembryos 被导出的转换字符(NT 转换字符) 线。我们发现 NT 转换字符能够形成胚胎植物或动物身体。另外, NT 转换字符表示了 pluripotency 干细胞标记试管内并且能区分进胚胎的纸巾体内。从施主房间能形成完整的术语的早经过 R1 的 NT 胚胎开发了小狗,而那些为为实时出生是必要的 reprogramming 从迟了的经过 R1 ES 施主房间失去了潜力。我们随后建立了近来从 NT 胚囊被开发的 sequentialNT-R1-ESC 线经过 R1 转换字符施主。然而,当在他们的早段落用作原子转移施主时,这些 NT-R1-ESC 排队,没能导致实时小狗。这显示用顺序的 NT 转换字符的治疗学的克隆过程不能救居住在以前的施主代的发展缺乏。 | Chunli Zhao Ruqiang Yao Jie Hao Chenhui Ding Yong Fan Xiangpeng Dai Wei Li Tang Hai Zichuan Liu Yang Yu Yingying Wang Xiaojun Hou Weizhi Ji Qi Zhou Alice Jouneau Fanyi Zeng Liu Wang | 2007 | Cell Research2007，17，1： | 1 |
| 13 | An Investigation of Decision - Making Styles of Consumers in China 显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | 2001 | The Journal of Consumer Affairs2001，35，2： | 1 |
| 14 | Serum prostate-specific antigen and prostate volume predict long-term changes in symptoms and flow rate: results of a four-year, randomized trial comparing finasteride versus placebo显示文摘 | Claus G. Roehrborn Peter Boyle Donald Bergner Todd Gray Marc Gittelman Thomas Shown Arnold Melman R.Bruce Bracken Ralph deVere White Alice Taylor Daniel Wang Joanne Waldstreicher | 1999 | Urology1999，，4： | 1 |
| 15 | Midostaurin does not prolong cardiac repolarization defined in a thorough electrocardiogram trial in healthy volunteers显示文摘 | Adam del Corral Catherine Dutreix Alice Huntsman-Labed Sebastien Lorenzo Joel Morganroth Robert Harrell Yanfeng Wang | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 1 |
| 16 | The nucleoporin Nup 96 is required for proper expression of interferon-regulated proteins and functions 显示文摘 | Faria A M Levay A Wang Y M Alice O K Rosa M L | 2006 | Immunity2006，24，3： | 1 |
| 17 | SmartReflex Power and Performance Management Technologies for 90 nm,65 nm,and 45 nm Mobile Application Processors显示文摘 | GAMMIE GORDON WANG ALICE MAIR HUGH | | 0，，02： | 1 |
| 18 | Local Expression of B7-H4 by Recombinant Adenovirus Transduction in Mouse Islets Prolongs Allograft Survival显示文摘 | Xiaojie Wang Jianqiang Hao Daniel L. Metzger Alice Mui Ziliang Ao C Bruce Verchere Lieping Chen Dawei Ou Garth L. Warnock | 2009 | Transplantation2009，，4： | 1 |
| 19 | An investigation of decision-making styles of consumers in China显示文摘 | Hiu Alice S Y Noel Y M Siu Charlie C L Wang Ludwig M K Chang | | 0，，02： | 1 |
| 20 | Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer' s disease- experimental approach and therapeutie implications 显示文摘 | Jun Wang Weina Bi Alice Cheng | 2014 | Frontiers in Aging Neuroseienee2014，6，42： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员