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| 1 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 2 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 3 | On Ohtsuki's Invariants of Integral Homology 3-Spheres | Xiaosong Lin Zhenghan Wang Department of Mathematics, University of California, Riverside, CA 92521, U. S. A.Department of Mathematics, Indiana University, Bloomington, IN 47405, U. S. A. Department of Mathematics, University of California, La Jolla, CA 92093, U. S. A. | 1999 | Acta Mathematica Sinica,English Series1999，15，3： | 6 |
| 4 | The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People显示文摘Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high-salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people. | LI Kui LIANG Yu SUN Yin ZHANG Ling Xia YI Xin CHEN Yong GU SANG LA MU WANG Jian | 2012 | Biomedical and Environmental Sciences2012，25，5： | 6 |
| 5 | A new method for evaluating the drought tolerance of upland rice cultivars显示文摘Worldwide, approximately 27 million ha of rice are grown in upland rather than paddy fields, and is subject to drought stress. To counter this stress, it is desirable to breed new rice cultivars with improved drought tolerance. For breeding purposes, especially for breeding upland rice, it is desirable to develop a simple and accurate method to evaluate rice drought tolerance. We describe a new method that can be used to evaluate efficiently the drought tolerance degree(DTD) of upland rice cultivars, and call it the DTD method.DTD is defined as the mean of the ratios of green leaf length to total leaf length of the top three leaves in every rice seedling after drought treatment, and thus takes values from zero to one. To test whether the DTD method works effectively to evaluate drought tolerance of upland rice cultivars, we determined the DTD values of 13 upland rice cultivars showing varying degrees of drought tolerance in drought-tolerance trials. The idrl-1 mutant, which displayed the strongest drought tolerance of the 13 cultivars as identified by drought-tolerance trials under severe drought stress, had the highest DTD value and297-28, displaying the weakest drought tolerance, had the lowest DTD value. Further analyses of water potential, survival rate, panicles per plant, spikelets per panicle, seed setting rate, yield per plant, and contents of proline, chlorophyll, and malondialdehyde(MDA) indicated that DTD values are in general correlated with the values of these traits,making this new method useful for assessing the drought tolerance of upland rice cultivars.These results show that the DTD method is a simple, direct and relatively accurate evaluation method for drought-tolerance breeding of upland rice. | Xiaofeng Zu Yanke Lu Qianqian Wang Peifeng Chu Wei Miao Huaqi Wang Honggui La | 2017 | The Crop Journal2017，5，6： | 5 |
| 6 | Characteristics of deep drainage and soil water in the mobile sandy lands of Inner Mongolia, northern China显示文摘Quantification of deep drainage and the response of soil water content to rainfall patterns are critical for an effective management strategy of soil water conservation and groundwater utilization. However, there has been little information on how rainfall characteristics influence soil water dynamics and deep drainage in mobile sandy lands. We used an underground chamber to examine the responses of deep drainage and soil water content in mobile sandy lands to rainfall characteristics in Inner Mongolia during the growing seasons of 2010, 2011 and 2012. Results showed that rainfall in this area was dominated by small events(≤5 mm), which increased soil water content in the surface soil layers(0–40 cm), but did not increase soil water content in the deeper soil layers(greater than 40 cm). Soil water content at the 0–100 cm depth increased significantly when the total amount of rain was >20 mm. Rainfall amount, intensity and the duration of dry intervals were significantly related to the soil water content in different soil layers. Deep drainage was significantly correlated with rainfall amount and intensity, but not with the duration of dry intervals. The coefficients of deep drainage in the mobile sandy lands ranged from 61.30% to 67.94% during the growing seasons. Our results suggested that rainfall infiltration in the mobile sandy lands had considerable potential to increase soil water storage while recharging the groundwater in this region. | Xin Ping LIU Yu Hui HE Xue Yong ZHAO Tong Hui ZHANG La Mei ZHANG Yun Hua MA Shu Xia YAO Shao Kun WANG Shui Lian WEI | 2015 | Journal of Arid Land2015，7，2： | 4 |
| 7 | Frictional Behavior of a Micro-sized Superconducting Fiber in a Low-Temperature Medium: Experimental and Computational Analysis显示文摘 | Shiren La Jun Wang Xingyi Zhang Youhe Zhou | 2018 | Acta Mechanica Solida Sinica2018，31，4： | 3 |
| 8 | Modified Glasgow Prognostic Score, and Neutrophil/lymphocyte and Platelet/lymphocyte Ratios in Different Stages of Silicosis显示文摘Until now, although comprehensive management strategies have improved treatment, there are no treatments to alleviate symptoms and slow disease progression[1]. In the past few decades, there has been increasing evidence that inflammation plays a very important role in silicosis. Injury-induced inflammation is an effective strategy to remove harmful stimuli and initiate a healing process. However, it might be harmful to the organism and result in a permanent disease state if the inflammation is prolonged[2]. | HE La Gu WU Peng Fei PENG Yan Hua FENG Juan ZHONG Dai Ming ZHANG Gui Hua ZENG Lei ZHONG Yu Min WANG Xiao Ye YUAN Hua Min | 2019 | Biomedical and Environmental Sciences2019，32，5： | 3 |
| 9 | Investigation on Relationship between Lubricating Performance and Stability of Emulsion for Cold Strip Rolling显示文摘比率的影响和为冷长带滚动的阴离子乳剂的稳定性上的 emulsifiers 的内容在学习也调查了的在场的这 paper.The 被调查 HLB ( hydrophile-lipophile 平衡)的效果不同稳定性和不同集中的效果上的没有离子的 emulsions.Based 的稳定性上的价值和 emulsifier 内容 adsorptivity 和磨擦系数上的乳剂,当时。 | Sun Jianlin Wang Yizhu La Rui Wang Bing (School of Material Science and Engineering,University of Science and Technology Beijing,Beijing 100083) | 2010 | China Petroleum Processing & Petrochemical Technology2010，12，3： | 3 |
| 10 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 11 | 载脂蛋白E基因型影响老年人心输出量与认知功能的相关性显示文摘心输出量的轻微下降与低脑血流量相关,尤其是在阿尔茨海默病病理改变的首发区域。载脂蛋白E(apolipoprotein E,APOE)-ε4是阿尔茨海默病的一个遗传易感性危险因素,同时能减轻血管损伤。该研究旨在探讨携带APOE-ε4基因是否影响心输出量与认知功能的相关性。研究人员纳入范德比尔特记忆老化项目中无临床脑卒中和痴呆的参与者306例,平均年龄(73±7)岁,其中42%为女性。 | 陈嘉睿 刘莉 Bown CW Liu D Osborn KE Gupta DK Mendes LA Pechman KR Hohman TJ Wang TJ Gifford KA Jefferson AL | 2019 | 中华高血压杂志2019，27，10： | 2 |
| 12 | Synthesis and biological evaluation of glyco-GA compounds as anticancer agents显示文摘A series of novel glyco-gambogic acid(GA) compounds were synthesized and evaluated for their in vitro anti-proliferative activity against human hepatocellular carcinoma(HCC) cells.All compounds showed much better aqueous solubility(0.92- 1.89 mg/mL) than GA(0.013 mg/mL),and displayed potent inhibition on HCC cells(IC_(50):0.21-12.23μmol/L) and little affects on non-tumor liver cells(IC_(50):42.56-86.43μmol/L),suggesting that glyco-GA compounds selectively inhibit HCC proliferation,and may be promising candidates for further intensive study. | Li Qin He Zhong Hu La Mei Yuan Xiao Shan Wang Yi Hua Zhang | 2012 | Chinese Chemical Letters2012，23，4： | 2 |
| 13 | Potential energy curves for the X^1Σ_g^+, B^1△_g and B′~1Σ_g^+ states of C_2 using MRCI and approximate CI methods显示文摘The potential energy curves for the X1Σ g+, B1△g and B′1Σ g+ states of C2 have been studied by using MRC and approximate CI methods, and are benchmarked against the calculations of full configuration in teraction (FCI). The results obtained by MRCI method agree with the FCI very well, and even are accu rate enough to compare other approximate methods as benchmark, when the calculations of FCI ar not feasible. The approximate CI methods mentioned in this paper are reliable for treating chemica problems. | LI AnYang1, WANG YuBin2, DOU YuSheng1,3 & WEN ZhenYi1,2 1 Institute of Bio-information, Chongqing University of Post and Telecommunication, Chongqing 400065, China 2 Institute of Modern Physics, Northwest University, Xi’an 710069, China 3 Department of Physical Sciences, Nicholls State University, PO Box 2022, Thibodaux, LA 70310, U. S. A | 2007 | Science China Chemistry2007，50，5： | 2 |
| 14 | Characterization of terpenoids and norisoprenoids from base and retail Qingke Baijiu by GC×GC-TOFMS and multivariate statistical analysis显示文摘Qingke(highland barley)Baijiu is a special Chinese Baijiu which is mainly produced from Qinghai-Tibet Plateau.Since the pine board is used as the bottom of the fermentation pit,we deduced that the terpenoids and norisoprenoids in pine board might be introduced into Qingke Baijiu.Thus,the terpenoids and norisoprenoids in Qingke Baijiu were investigated by headspace solid phase microextraction(HS-SPME)combined with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry(GC×GC-TOFMS).The results showed thatγ-terpinene(0.70-530.72μg/L),α-phellandrene(0.34-256.66μg/L),longicyclene(0-38.55μg/L),α-pinene(1.21-35.54μg/L)and limonene(0.93-23.69μg/L)were the top 5 terpenoids/norisoprenoids in Qingke Baijiu.Pulegone was detected and reported for the first time in Baijiu,and the concentrations in Qingke Baijiu were 0.78μg/L(fresh)and 3.90μg/L(7 years old).According to the principal component analysis(PCA)plot,young,aged,and retail Qingke Baijiu could be differentiated clearly.Fold change(FC)and t-tests analysis indicated thatβ-pinene,γ-terpinene,andα-selinene were the most different terpenoids/norisoprenoids between young and aged Qingke Baijiu,and longifolene was the most different terpenoids/norisoprenoids between base and retail Qingke Baijiu.The terpenoids and norisoprenoids,such as(E)-β-ionone,isoborneol andβ-cyclocitral,could be potential markers indicating the ageing process of Qingke Baijiu. | Xinlei Wang Lin Zhu Xuebo Song Si Jing Fuping Zheng Mingquan Huang Shengbao Feng Luzhong La | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 15 | Spleen-kidney supplementing formula alleviates insulin resistance via regulating AKT/glycogen synthase kinase 3β pathway in rats with type 2 diabetic induced by high-fat diet显示文摘OBJECTIVE: To explore the molecular mechanism underpinning the action by investigating its effect on glycogen content and AKT(also known as protein kinase B)/glycogen synthase kinase 3β(GSK-3β) pathway in the liver of rats with type 2 diabetic induced by high-fat diet.METHODS: The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injection. Diabetic rats were divided into five groups: the model control group, the Metformin group, spleen-kidney supplementing formula groups of low, medium and high doses. Fasting blood glucose(FBG) levels were measured before treatment and every two weeks during treatment.After the treatment, oral glucose tolerance test was performed, and hemoglobin A1c (HbA1c) and C-peptide were measured to assess the formula's effect on glucose metabolism and insulin resistance. The protein expression levels of AKT, GSK-3βand their phosphorylated forms in the liver were also measured to study the formula's role in insulin signaling pathway.RESULTS: Spleen-kidney supplementing formula significantly relieved the symptoms of polydipsia,polyuria and weight loss in type 2 diabetic rats, reduced FBG and HbA1c levels, increased glycogen content, and improved insulin sensitivity. The anti-diabetic effects of spleen-kidney supplementing formula are dose dependent. It also increased the total AKT protein level and the GSK-3β phosphorylation in the liver of type 2 diabetic rats.CONCLUSION: Spleen-kidney supplementing formula has hypoglycemic effect and relieves insulin resistance by enhancing AKT/GSK-3β signaling pathway in the liver of type 2 diabetic rats. | Tian Chunyu Wang Ya La Xiaojin Li Ji'an Zhang Biwei | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 2 |
| 16 | Correlation of DNA methylation patterns to the phenotypic features of Tibetan elite alpinists in extreme hypoxia显示文摘High altitude is an extreme environment that imposes hypoxic pressure on physiological processes,and natives living at high altitudes are more adaptive in certain physiological processes.So far,epigenetic modifications under extreme changes in hypoxic pressures are relatively less understood.Here,we recruit 32 Tibetan elite alpinists(TEAs),who have successfully mounted Everest(8848 m)at least five times.Blood samples and physiological phenotypes of TEAs and 32 matched non-alpinist Tibetan volunteers(non-TEAs)are collected for analysis.Genome-wide DNA methylation analysis identifies 23,202 differentially methylated CpGs(P_(adj)<0.05,|β|>0.1)between the two groups.Some differentially methylated CpGs are in hypoxia-related genes such as PPP1R13L,MAP3K7CL,SEPTI-9,and CUL2.In addition,Gene ontology enrichment analysis reveals several inflammation-related pathways.Phenotypic analysis indicates that 12 phenotypes are significantly different between the two groups.In particular,TEAs exhibit higher blood oxygen saturation levels and lower neutrophil count,platelet count,and heart rate.For DNA methylation association analysis,we find that two CpGs(cg16687447,cg06947206)upstream of PTEN were associated with platelet count.In conclusion,extreme hypoxia exposure leads to epigenetic modifications and phenotypic alterations of TEA,providing us clues for exploring the molecular mechanism underlying changes under extreme hypoxia conditions. | Zhuoma Basang Shixuan Zhang La Yang Deji Quzong Yi Li Yanyun Ma Meng Hao WeiLin Pu Xiaoyu Liu Hongjun Xie Meng Liang Jiucun Wang Qiangba Danzeng | 2021 | Journal of Genetics and Genomics2021，48，10： | 2 |
| 17 | High doseint ravenous methot rexate in multiple sclerosis patient sworsening despite Avonex therapy:final results显示文摘 | Dressman LA Wang D | 2004 | Neurology2004，62，5： | 1 |
| 18 | Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later 显示文摘 | Morrison JA Friedman LA Wang P | 2008 | J Pediatr2008，152，2： | 1 |
| 19 | Metabolic syndrome in child- hood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later显示文摘 | Morrison JA Friedman LA Wang P | 2008 | J Pediatr2008，152，2： | 1 |
| 20 | Identification and analysis of an interleukin 8 - like molecule in rainbow trout Oncorhynchus mykiss 显示文摘 | Laing K J Zou J J Wang T | 2002 | Dev Comp Immunol2002，26，5： | 1 |
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