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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 3 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 4 | Plant vintage, technology, and environmental regulation显示文摘 | Wayne B Gray Ronald J Shadbegian | 2003 | Journal of Environmental Economics and Management2003，，3： | 3 |
| 5 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 6 | Theassociation of comorbid depression with mortality in patients withtype 2 diabetes显示文摘 | Katon Wayne J Rutter Carolyn PHD Simon Greg MD | 2005 | Diabetes Care2005，28，11： | 1 |
| 7 | Leader-Member Exchange, Differentiation, and Psychological Contract Fulfillment: A Multilevel Examination 显示文摘 | HENDERSON D J WAYNE S J SHORE L M | 2008 | Journal of Applied Psychology2008，93，6： | 1 |
| 8 | An examination of per- ceived organizational support as a multidimensional construct in the context of an expatriate assign- ment显示文摘 | Kraimer M L Wayne S J | 2004 | Journal of Management2004，30，2： | 1 |
| 9 | A Daytime Complement to the Reverse Absorption Technique for Improved Automated Detection of Volcanic Ash显示文摘 | Michael J P Wayne F F Andrew K H | 2006 | Journal of Atmospheric and Ocean Technology2006，23，11： | 1 |
| 10 | In vivo response of polylactic acid-alginate scaffolds and bone marrow-derived cells for cartilage tissue engineering显示文摘 | Wayne J S McDowell C L Shields K J | 2005 | Tissue Eng2005，11，56： | 1 |
| 11 | 显示文摘 | Jason C Wayne D Mader J T | 1988 | J Bone Joint Surg (Am)1988，70，： | 1 |
| 12 | Iliac vein compression syndrome : a new method of treatment 显示文摘 | Baron HC Shams J Wayne M | 2000 | Am Surg2000，66，： | 1 |
| 13 | Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association显示文摘 | Li W H Wayne A | 2004 | PNAS2004，101，8： | 1 |
| 14 | Commitment and employee behavior:Comparison of affective commitment and continuance commitment with perceived organizational support显示文摘 | Shore L M Wayne S J | 1993 | Journal of Applied Psychology1993，78，5： | 1 |
| 15 | Modified Starch-based Biodegradable Particles 显示文摘 | Wayne J Maddever Graham M Chapman | 1989 | Plastics Engineering1989，45，7： | 1 |
| 16 | Commitment and Employee Behavior:Comparison of Affective Commitment and Continuance Commitment with Perceived Organizational Support 显示文摘 | Shore L M Wayne S J | 1993 | Journal of Applied Psychology1993，78，5： | 1 |
| 17 | The impact of psychological contract breach on work-related outcomes:a meta-analysis显示文摘 | Zhao H Wayne S J Glibkowski B C | 2007 | Personnel Psychology2007，60，3： | 1 |
| 18 | Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 yeas 显示文摘 | BILIMORIA K Y BENTREM D J WAYNE J D | 2009 | Ann Surg2009，249，1： | 1 |
| 19 | The im- pact of psychological contract breach on workrelated out- comes : a meta-analysis 显示文摘 | ZHAO Hao WAYNE S J GLIBKOWSKI C | 2007 | Personnel Psychology2007，60，3： | 1 |
| 20 | Controlled versus conventional drainage effects on water quality显示文摘 | Evans RO Wayne Skaggs R Wendell Gilliam J | 1995 | Journal of Irrigation and Drainage Engineering1995，121，4： | 1 |
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