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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Early revascularization in acute myocardial infarction complicated by cardiogenic shock显示文摘 | HOCHMAN J S SLEEPER L A WEBB J G | 1999 | N Eng J Med1999，341，： | 1 |
| 3 | Building Corporate Associations:Consumer Attributions for Corporate Socially Responsible Programs 显示文摘 | Ellen P S Webb D J Mohr L A | 2006 | Journal of the Academy of Marketing Science2006，34，2： | 1 |
| 4 | Heat transfer enhancement:second generation technology显示文摘 | Webb R L Bergles A E | | 0，，06： | 1 |
| 5 | Heat transfer enhancement: second generation technology显示文摘 | Webb R L Bergles A E | 1983 | Mechanical Engineering1983，105，6： | 1 |
| 6 | Do consumers expect companies to be socially responsible? The impact of corporate social responsibility on buying behavior显示文摘 | Mohr L A Webb D J Harris K E | 2001 | Journal of Consumer Affairs2001，35，1： | 1 |
| 7 | Attenuation of solar radiation by a water mist from the ultraviolet to the infrared range 显示文摘 | DOMBROVSKY L A SOLOVJOV V P WEBB B W | 2011 | Journal of Quantitative Spectroscopy &Radiative Transfer2011，112，7： | 1 |
| 8 | The Effects of Corporate Social Responsibility and Price on Consumer Responses 显示文摘 | Mohr L A Webb D J | 2005 | Journal of Con- sumer Affairs2005，39，1： | 1 |
| 9 | The effects of corporate social responsibility and price on consumer responses显示文摘 | Mohr L A and Webb D J | 2005 | Journal of Consumer Affairs2005，39，1： | 1 |
| 10 | Arsenic localization, speciation, and with iron on rice (Oryza sativa L) roots having variable Fe coatings显示文摘 | Seyfferth A L Webb S M Andrews J C | 2010 | Environmental Science & Technology2010，44，21： | 1 |
| 11 | The Effects of Corporate Social Re- sponsibility and Price on Consumer Responses 显示文摘 | Mohr L A Webb D J | 2005 | Journal of Consumer Affairs2005，39，1： | 1 |
| 12 | Do Con- sumers Expect Companies to Be Socially Responsi- ble? The Impact of Corporate Social Responsibility on Buying Behavior显示文摘 | MOHR L A WEBB D J HARRIS K E | 2001 | The Journal of Consumer Affairs2001，35，1： | 1 |
| 13 | Nueleotide sequence of human monocyte interleukin 1 precursor cDNA Proc Natl Acad Sci USA显示文摘 | AURON P E WEBB A C ROSENWASSER L J | 2007 | J Immunol2007，178，9： | 1 |
| 14 | Sorbitol translocation in apple显示文摘 | Webb K L Burley J W A | 1962 | Science1962，137，： | 1 |
| 15 | Homologous sequences in the Campoletis sonorensis polydnavirus genome are implicated in replication and nesting of the segment family显示文摘 | CUI L WEBB B A | 1997 | Journal of Virology1997，71，： | 1 |
| 16 | Interactions between plant circadian clocks and solute transport 显示文摘 | HAYDON M J BELL L J WEBB A A R | 2011 | Journal of Experimental Botany2011，62，7： | 1 |
| 17 | Building corporate associa?tions: consumer attributions for corporate socially responsi?ble programs显示文摘 | Ellen P S Webb DJ Mohr L A | 2006 | Journal of the Academy of Marketing Sci?ence2006，34，2： | 1 |
| 18 | Diversity in nucleotide binding site-leucine-rich repeat genes in cereals 显示文摘 | Bai J Pennill L A Ning J Lee S W Ramalingam J Webb C A Zhao B Sun Q Nelson J C Leach J E Hulbert S H | 2002 | Genome Research2002，12，12： | 1 |
| 19 | Relationships between polydnavirus genomes and viral gene expression显示文摘 | CUI L WEBB B A | 1998 | Journal of Insect Physiology1998，44，： | 1 |
| 20 | Land use dynamics and landscape change pattern in a mountain watershed in Nepal显示文摘 | Ambika P Gautam Edward L Webb Ganesh P Shivakoti Michael A Zoebisch | 2003 | Agriculture Ecosystems and Environment2003，，1： | 1 |
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