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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Cell migration at a glance显示文摘 | Vicente-Manzanares M Webb D J Horwitz A R | 2005 | J Cell Sci2005，118，21： | 1 |
| 3 | Long-term evaluation of phosphorus and zinc interactions in corn 显示文摘 | Mallarino A P Webb J R | 1995 | Journal of Production Agriculture1995，8，1： | 1 |
| 4 | Boardinvited review: peptide absorption and utilization: implications for animal nutrition and health 显示文摘 | GILBERT E R WONG E A WEBB K E Jr | 2008 | Journal of Animal Science2008，86，9： | 1 |
| 5 | Kinetic parameters of Aspergillus awamori in submerged cultivations on whole wheat flour under oxygen limiting conditions 显示文摘 | Koutinas A A Wang R Kookos I K Webb C | 2003 | Biochemical Engineering Journal (S1369-703X)2003，16，1： | 1 |
| 6 | Fingerprink blood samples can be used to accurately measure tacrolimus levels by tandem mass spectrometry 显示文摘 | WEBB N J A ROERTS D PREZIOSI R | 2005 | Pediatr Transplantation2005，9，6： | 1 |
| 7 | Heat transfer enhancement:second generation technology显示文摘 | Webb R L Bergles A E | | 0，，06： | 1 |
| 8 | The microRN A expres?sion changes associated with malignancy and SDHB mutation in pheochromocytoma显示文摘 | Patterson E Webb R Weisbrod A | 2012 | Endocr Relat Cancer2012，19，2： | 1 |
| 9 | Heat transfer enhancement: second generation technology显示文摘 | Webb R L Bergles A E | 1983 | Mechanical Engineering1983，105，6： | 1 |
| 10 | Artemisinins target the SERCA of Plasmodium falciparum显示文摘 | Eckstein-Ludwig U Webb R J van Goethem I D A | 2003 | Nature2003，424，： | 1 |
| 11 | Development of a process for the production of nutrient supplements for fermentations based on fungal autolysis 显示文摘 | Koutinas A A Wang R H Webb C | 2005 | Enzyme and Microbial Technology2005，36，1： | 1 |
| 12 | Managing soil organic matterimplications for soil structure on organic farms显示文摘 | SHEPHERD M A HARRISON R WEBB J | 2002 | Soil Use and Management2002，18，： | 1 |
| 13 | Genetic variation in the DNA repair genes is predictive of outcome in Lung cancer显示文摘 | Matakidou A el Galta R Webb EL | 2007 | Hum Mol Genet2007，16，19： | 1 |
| 14 | Board-invited re- vicw:peptide absorptio and utilization:implications for animal nutrition and health 显示文摘 | Gilbert E R Wong E A Webb K E | 2008 | Journal of Animal Sci- ence2008，86，9： | 1 |
| 15 | Nobel citric acid-basedbiodegradable elastomers for tissue engineering显示文摘 | Yang J Webb A R Ameer G A | 2004 | AdvMater2004，16，： | 1 |
| 16 | Cell migration at a glance显示文摘 | Vicente-Manzanares M Webb D J Horwitz A R | 2005 | J Cell Sci2005，118，21： | 1 |
| 17 | Unreferred chronic kidney disease:a longitudinal study显示文摘 | John R Webb M Young A | 2004 | Am J Kidney Dis2004，43，5： | 1 |
| 18 | Activation of NADPH oxidase involves the dissociation of p21^Rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane 显示文摘 | ABO A WEBB M R GROGAN A etal | 1994 | Biochem J1994，，298： | 1 |
| 19 | Interactions between plant circadian clocks and solute transport 显示文摘 | HAYDON M J BELL L J WEBB A A R | 2011 | Journal of Experimental Botany2011，62，7： | 1 |
| 20 | All optical loop mirror switch employing an asymmetric amplifier/attenuator combination 显示文摘 | ONEILL A W WEBB R P | 1990 | Electron Lett1990，26，24： | 1 |
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