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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Minimum criteria for immediate provisionalization of single-tooth dental implants in extraction sites:a 1-year retrospective study of 100 consecutive cases显示文摘 | BECKER C M WILSON T J JENSEN O T | 2011 | J Oral Maxillofac Surg2011，69，2： | 1 |
| 3 | Instrumentation and monitoring of an engineered soil cover system for mine waste rock显示文摘 | O'KANE M WILSON G W BARBOUR S L | 1998 | Can Geotech J1998，35，5： | 1 |
| 4 | Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering显示文摘 | BONETTI P O WILSON S H RODRIGUEZ-POR- CEL M | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 5 | Beta (3) integrin expression increases breast carcinoma cell responsiveness to the malignancy enhancing effects of osteopontin显示文摘 | Furger K A Allan A L Wilson S M Hota C Vantyghem S A Postenka C O | 2003 | Mol Cancer Res2003，1，： | 1 |
| 6 | Dolomitization front geometry,fluid flow patterns and the origin of massive dolomite 显示文摘 | Wilson E N Hardie L A Phillips O M | 1990 | America Journal of Science1990，290，5： | 1 |
| 7 | The role of rituximab and chemotherapy in aggressive B-cell lymphoma:a preliminary report of dose-adjusted EPOCH-R显示文摘 | Wilson WH Gutierrez M O′Connor P | 2002 | Semin Oncol2002，29，12： | 1 |
| 8 | The role of rituximab and chemotherapy in aggressive B-cell lymphoma: a preliminary report of dose- adjusted EPOCH - R显示文摘 | Wilson W H Gutierrez M O'Connor P | 2002 | Semin Oncol2002，29，12： | 1 |
| 9 | The effect of photodynamie action on two virulence factors of gram-negative bacteria显示文摘 | K(o)merik N Wilson M Poole S | 2000 | Photochem Photobiol2000，72，5： | 1 |
| 10 | Distribution of phosphorus in soil aggregate fractions and its significance with regard to phosphorus transport in agricultural runo显示文摘 | He Z L Wilson M J Campbell C O | 1995 | Water Air and Soil Pollution1995，83，12： | 1 |
| 11 | Implementation on Landsat Data of a Simple Cloud-mask Algorithm Developed for MODIS Land Bands显示文摘 | Lazaros O Wilson M J Vrnai | 2011 | IEEE Geoscience and Remote Sensing Letters2011，8，4： | 1 |
| 12 | Synthesis,characterization,and applications of en drimer-encapsulated nanoparticles 显示文摘 | Scott r W J Wilson O M CrookS R M | 2005 | Journal of Physical Chemistry B2005，109，2： | 1 |
| 13 | OFDM Channel Estimation by Sigular Value Decomposition 显示文摘 | SANDELL O E M BEEK J V D WILSON S K | 1998 | IEEE Trans Commun1998，46，7： | 1 |
| 14 | Infrared spectrum of SOF2显示文摘 | KENNETH O'LOANE J WILSON K M | 1955 | The Jourual of Chemical Physics1955，23，7： | 1 |
| 15 | Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling显示文摘 | Li YF Cheng YF Huang Y Conti M Wilson SP O'Donnell JM | 2011 | J Neurosci2011，31，1： | 1 |
| 16 | Effects of perches on trabecular bone volume in laying hens显示文摘 | Wilson S B O Hughes M C Appleby | 1993 | Res Vet Sci1993，54，： | 1 |
| 17 | Instrumentation and monitoring of an engineered soil cover system for mine waste rock显示文摘 | Wilson G W Barbour S L | 1998 | Can Geotech J1998，35，5： | 1 |
| 18 | Targeting cultivars onto rice growing environments using AMMI and SREG GGE biplot analyses显示文摘 | Samonte S O P B Wilson L T McClung A M | 2005 | Crop Sci2005，45，： | 1 |
| 19 | Targetingcultivars onto rice growing environments using AMMI andSREG GGE biplot analyses显示文摘 | Samonte S O P Wilson L T Mcclung A M | 2005 | Crop Science2005，45，6： | 1 |
| 20 | Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful dia- betic neuropathy patients 显示文摘 | Hanna M O' Brien C Wilson MC | 2008 | Eur J Pain2008，12，6： | 1 |
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