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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Compensation for the effects of linear motion in MR imaging 显示文摘 | Korin HW Farzaneh F Wright RC | 1989 | Magn Reson Med1989，12，1： | 2 |
| 3 | A United States compassionate use study of lamivudine treatment in nontrans plantation candidates with decompensated hepatitis B virus- related cirrhosis 显示文摘 | Hann HW Fontana RJ Wright T etal | 2003 | Liver Transpl2003，9，1： | 1 |
| 4 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana ed Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
| 5 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
| 6 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Fontana RJ Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
| 7 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，： | 1 |
| 8 | A multicenter study of lamivudine treatment in 33 patients with hepatitis B after liver transplantation 显示文摘 | Fontana R J Hann HW Wright T | 2001 | Liver Transpl2001，7，6： | 1 |
| 9 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates, with decompensated hepatitis B virus -relatrd cirrhosis 显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
| 10 | A United States compas- sionate use study of lamivudine treatment in nontransplantation candi- dates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Harm HW Fontana R J Wright T | 2003 | Liver Transp12003，9，1： | 1 |
| 11 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，： | 1 |
| 12 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transplantation2003，14，3： | 1 |
| 13 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
| 14 | A multicenter study of lamivudine treatment in 33 patients with hepatitis B after liver transplantation显示文摘 | Fontana RJ Hann HW Wright T | 2001 | Liver Transpl2001，7，6： | 1 |
| 15 | Administration of a highly attenuated, live respiratory syncytial virus vaccine to adults and children 显示文摘 | Wright PF Belshe RB Kim HW | 1982 | Infect Immun1982，37，1： | 1 |
| 16 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | HANN HW FONTANA R J WRIGHT T | 2003 | Liver Transpl2003，9，： | 1 |
| 17 | A United States com-passionate use study of lamivudine treatment in nontransplan-tation candidateswith decompensated hepatitis B virus2relatedcirrhosis 显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，： | 1 |
| 18 | A United States com-passionate use study of lamivudine treatment in nontransplan-tation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
| 19 | A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
| 20 | A United States com-passionate use study of lamivudine treatment in nontrans-plantation candidates with decompensated hepatitis B virus-relatedcirrhosis 显示文摘 | Hann HW Fontana RJ Wright T | 2003 | Liver Transpl2003，9，1： | 1 |
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