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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | 血管周围脂肪组织中的Bmal1通过血管紧张素原转录调控管理静息期血压显示文摘血管周围脂肪组织(perivascular adipose tissue,PVAT)围绕血管,构成了在生理条件下保持血管张力所需的脉管系统的独特的功能整体层。然而,关于PVAT与血压调节之间的关系的资料很少,包括其对昼夜血压变化的潜在作用。 | Chang L Xiong W Zhao X Fan Y Guo Y Garcia-Barrio M Zhang J Jiang Z Lin JD Chen YE 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 23 |
| 3 | The compression of IR spectra by using wavelet neural network显示文摘IR spectra play an important role in determining the structure of compounds qualitatively andquantitatively.In general a great number of data are required to exactly show the features ofthe compounds.Regarding various compounds,there are massive IR spectra.With the basicfeatures of IR spectra being reserved,it is important to compress IR spectra for improving thestorage,index and process of IR spectra.The wavelet neural network(WNN)is a newneural network model based on wavelet analysis.However,its introduction and applica-tion in chemistry have not been reported.In this note,WNN is applied to the compression ofthe IR spectra of polystyrene.The results show that the original spectra can be | Liu, W Li, JP Xiong, JH Pan, ZX Zhang, MS | 1997 | Chinese Science Bulletin1997，42，10： | 8 |
| 4 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 5 | Rapid typing of tandemly repeated hypervariable loci by the polymerase chain react ion: application to the apolipoprotein B 3' hypervariable region显示文摘 | Boerwinkle E Xiong W J Fourest E | 1989 | Proc Natl Acad Sic USA1989，86，1： | 1 |
| 6 | Electroless Ni-P coating of cenospheres using silver nitrate activator 显示文摘 | Zeng A X Xiong W H Xu J | 2005 | Surface&Coatings Technology2005，197，23： | 1 |
| 7 | Ultra-high g deceleration-time measurement for the penetration into steel target显示文摘 | Zhang W D Chen L J Xiong Jijun | 2007 | International Journal of Impact Engineering2007，34，3： | 1 |
| 8 | Heterogeneous expectations and bond markets显示文摘 | Xiong W Yan H J | 2009 | Review of Financial Studies2009，23，4： | 1 |
| 9 | Alkaline syenites in eastern Cathaysia (South China): Link to Permian-Triassic transtension显示文摘 | Wang Q Li J W Jian P Zhao Z H Xiong X L Bao Z W Xu J F Li C F Ma J L | 2005 | Emth Planet Sci Lett2005，230，34： | 1 |
| 10 | Photoinduced dissociation of cyclobutane thymine dimer studied by sem- iclassical dynamics simulation 显示文摘 | DOU Y S XIONG S S WU W F | 2010 | J Photoch Photobio B2010，101，1： | 1 |
| 11 | Whole exon 5 and intron 5 replaced byRHCEin DVa(Hus) 显示文摘 | Shao C Xiong W Wang W | 2004 | J Hum Genet2004，49，2： | 1 |
| 12 | Effects of PC-SPES on proliferation and expression of AR/PSA in androgen-responsive LNCaP cells are independent of estradiol显示文摘 | Hsieh T C Xiong W Traganos F | 2002 | Anticancer Res2002，22，4： | 1 |
| 13 | A macroscopic approach to the lane for- mation phenomenon in pedestrian counterflow 显示文摘 | Xiong T Zhang P Wong S C Shu C W Zhang M | 2011 | Chinese Physical Letters2011，28，10： | 1 |
| 14 | Active energy image plus 2DLPP for gait recognition显示文摘 | Zhang E H Zhao Y W Xiong W | 2010 | Signal Processing2010，90，7： | 1 |
| 15 | Purification and developmental analysis of a metalloendoproteinase from the leaves of Glycine max显示文摘 | GRAHAM J S XIONG J GILLIKIN J W | 1991 | Plant Physiology1991，97，2： | 1 |
| 16 | Existence of positive solutions for the boundary value problem of nonlinear fractional differential equations显示文摘 | Xiong Y Zhong L W Wei D | 2012 | Commun Nonlinear Sci Numer Simulat2012，17，： | 1 |
| 17 | New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancre- atic β-cells : the involvement of the Wnt signaling pathway effector β- catenin显示文摘 | Xiong X Shao W Jin T | 2012 | Islets2012，4，6： | 1 |
| 18 | Multi-source temporal data aggregation in wireless sensor networks显示文摘 | Guo W Xiong N Vasilakos A V | 2011 | Wireless personal communications2011，56，3： | 1 |
| 19 | Anthrax lethal factor inhibition 显示文摘 | Shoop W L Xiong Y Wiltsie J | 2005 | Proc Natl Acad Sci U S A2005，102，22： | 1 |
| 20 | The Chinese Warrants Bubble显示文摘 | Xiong W J Yu | 2011 | A- merican Economic Review2011，101，6： | 1 |
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