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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Neuroendocrine cells in human prostate over-express the anti-apoptosis protein survivin显示文摘 | Xing N Qian J Bostwick D | | 0，，： | 2 |
| 4 | The properties of high-resolution range profiles显示文摘 | Xing M D Bao Z Pei B N | 2002 | Optical Engineering2002，41，2： | 2 |
| 5 | Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase显示文摘 | MUSI N FUJII N | 2003 | J biol Chem2003，278，28： | 1 |
| 6 | Transitional cell carcinoma in renal transplant recipients: a single cen- ter experience显示文摘 | LI X B Xing N Z Wang Y | 2008 | Int J Urol2008，15，： | 1 |
| 7 | Microbial community structure of ethanol type fermentation in bio-hydmgen production 显示文摘 | REN N Q XING D F ZHAO L H | 2007 | Environmental Microbiology2007，9，5： | 1 |
| 8 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 9 | Effects ofhigh-pressure processing on the cooking loss and gel strength of chicken breast actomyosin containing sodium alginate显示文摘 | CHEN Xing LI PeOun TADAYUKI N | 2014 | Food and Bioprocess Technology2014，7，12： | 1 |
| 10 | Continuous hydrogenproduction of auto-aggregative Ethanoligenens harbinense YUAN-3 under non-sterile condition显示文摘 | Xing D F Ren N Q Wang A J | 2008 | International Journal ofHydrogen Energy2008，33，5： | 1 |
| 11 | The longitudinal 'trapping' phenomenon in the simultaneous acceleration of intense H ^+ and H - in an RFQ 显示文摘 | Xing Q Z Fu S N Lin Y Z | 2005 | Nuclear Instruments and Methods in Physics Research : Section A2005，538，1： | 1 |
| 12 | Regulation of thioltransferase expression in human lens epithelial cells显示文摘 | RAGBAVACBARI N KRYSAN K XING K | 2001 | Investg Ophthalmol Vis Sci2001，42，5： | 1 |
| 13 | 查看详情显示文摘 | Xu Z Sheng L Xing D Y Prodan E Sheng D N | | 0，，： | 1 |
| 14 | Ethanoligenens harbinense gen nov, sp nov, isolated from molasses wastewater显示文摘 | Xing D Ren N Li Q | 2006 | Int J Syst Evol Microbiol2006，56，： | 1 |
| 15 | Regulation of thioltransferaseexpression in human lens epithelial cells显示文摘 | Ragbavacbari N Krysan K Xing K | 2001 | Invest Ophthalmol Vis Sci2001，42，5： | 1 |
| 16 | The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease显示文摘 | Packer A N Xing Y Harper S Q | 2008 | J Neurosci2008，28，14： | 1 |
| 17 | Adhesion of nanosizednickel catalysts in the nanocatalysis/UF system 显示文摘 | Zhong Z Xing W Jin W Xu N | 2007 | AIChE Journal2007，53，： | 1 |
| 18 | Beneficial effect of preventative intra-aortic balloon pumping in high-risk patients undergoing firsttime coronary artery bypass grafting-a single center experience显示文摘 | Gong QC Xing JL Miao N | | 0，，08： | 1 |
| 19 | Theory of colossal magnetoresistance in R1-xAxMnO3 显示文摘 | Sheng L Xing D Y Sheng D N | 1997 | Phys Rev Lett1997，79，： | 1 |
| 20 | Continuous hydrogen produc- tion of auto-aggregative Ethanoligenens harbinense YUAN-3 under non-sterile condition 显示文摘 | Xing D F Ren N Q Wang A J | 2008 | International Journal of Hydrogen Ener- gy2008，33，5： | 1 |
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