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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 3 | Augmentation of a loosened sacral pedicle screw with percutaneous polymethylmethacrylate injection 显示文摘 | Yilmaz C Atalay B Caner H | 2006 | J Spinal Disord Tech2006，5，： | 1 |
| 4 | 显示文摘 | Yilmaz S Dunand D C | 2004 | Composites Science and Fechnology2004，64，： | 1 |
| 5 | Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma显示文摘 | Gorio A Gokmen N Erbayraktar S Yilmaz O Madaschi L Cichehi C | 2002 | PNAS2002，99，4： | 1 |
| 6 | Anterior instrumentation for the treatment of spinal tuberculosis显示文摘 | Yilmaz C Selek HY Gtirkan I etal | 1999 | J Bone Joint Surg Am1999，81，9： | 1 |
| 7 | Comparison of the bond compatibility of titanium and Ni- cr alloy to dental porcelain显示文摘 | Yilmaz H Dincer C | 1999 | J Dent1999，27，3： | 1 |
| 8 | Anterior instrumentation for the treatment of spinal tuberculosis显示文摘 | YiLmaz C Selek H GrKan I | 1999 | J Bone Joint Surg (Am)1999，81，9： | 1 |
| 9 | Anterior instrumentation for the treatment of spinal tuberculosis 显示文摘 | Yilmaz C Selek H Grkan I | 1999 | J Bone Joint Surg (AM)1999，81，： | 1 |
| 10 | Antelor instrumention for the treatment of spinal tuberculosis显示文摘 | Yilmaz C Selek HY Gu Ran I | 1999 | J Bone Joint Surg(Am)1999，81，5： | 1 |
| 11 | Reduced retinal nerve fiber layer thickness and macular volume in pediatric multiple sclerosis显示文摘 | Yilmaz U Gücüyener K Erin DM | | 0，，12： | 1 |
| 12 | The diagnostic and prognostic significance of soluble urokinase plasminogen activator receptor in systemic inflammatory response syndrome显示文摘 | Yilmaz G Koksal 1 Karahan S C | 2011 | Clinical biochemistry2011，44，14： | 1 |
| 13 | Anterior instrumentation for the treatment of spinal tuberculosis显示文摘 | Yilmaz C Selek HY Gürkan I | 1999 | J Bone Joint Surg Am1999，81，9： | 1 |
| 14 | Anteror instrumentation for the treatment of spinal tuberculosis显示文摘 | Yilmaze C Selek HY | 1999 | J Bone Surg(Am)1999，81，9： | 1 |
| 15 | Finite-element analysis of thermal expansion and thermal mismatch stresses in a Cu-60%ZrW2O8 composite显示文摘 | YILMAZ S DUNAND D C | 2004 | Compos Sci Technol2004，64，： | 1 |
| 16 | Comparison of the bond compatibility of titanium and an NiCr alloy to dental porcelain显示文摘 | Yilmaz H Dincer C | 1999 | J Dent1999，27，3： | 1 |
| 17 | Analysis and design of passive band-stop filter-type vibration isolators for low-fre- quency applieations显示文摘 | Yilmaz C Kikuchi N | 2006 | Journal of Sound and Vibra- tion2006，291，： | 1 |
| 18 | Massive subcutaneous emphysema involving the head and neck after laparoscopic Roux- en-Y gastric by-pass: case report 显示文摘 | Kayaalp C Yilmaz S Aydin C | 2010 | Eur J Sci2010，1，2： | 1 |
| 19 | Survival rates and periimplant soft tissue evaluation of extraoral implants over a mean follow-up period of three years 显示文摘 | Karakoca S Aydin C Yilmaz H | 2008 | J Prosthet Dent2008，100，6： | 1 |
| 20 | Spontaneous supratentorial intracerebral hemorrhage:does surgery benefit comatose patients?显示文摘 | Yilmaz C Kabatas S Gulsen S | 2010 | Ann indian Acad Neurol2010，13，3： | 1 |
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