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| 1 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 2 | Graphene-based catalysts for electrochemical carbon dioxide reduction显示文摘Electrochemical carbon dioxide(CO2)reduction is considered to be an efficient strategy to produce usable fuels and overcome the concerns regarding global warming.For this purpose,an efficient,earth abundant,and a low cost catalyst has to be designed.It has been found that graphene-based materials could be promising candidates for CO2 conversion because of their unique physical,mechanical,and electronic properties.In addition,the surface of graphenebased materials can be modified by using different strategies,including doping,defect engineering,producing composite structures,and wrapping shapes.In this review,the fundamentals of electrochemical CO2 reduction and recent progress of graphene-based catalysts are investigated.Furthermore,recent studies on graphene-based materials for CO2 reduction are summarized. | Amirhossein Hasani Mahider Asmare Teklagne Ha Huu Do Sung Hyun Hong Quyet Van Le Sang Hyun Ahn Soo Young Kim | 2020 | Carbon Energy2020，2，2： | 7 |
| 3 | Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle显示文摘The safety of nanomaterials, a crucial consideration for clinical translation, is enhanced by using building blocks that are biologically nontoxic. Here, we used poly(γ-glutamic acid)(γ-PGA) and dopamine as building blocks of polymeric nanomaterials for carrying hydrophobic anticancer drugs. The introduction of phenylalanine onto γ-PGA enabled the resulting amphiphilic derivative of γ-PGA acid to self-assemble in the presence of the anticancer drug paclitaxel(PTX) to form PTX-encapsulated micelles.The surfaces of PTX-loaded micelles were then coated with polymerized dopamine(PDA). The PDAcoated, amphiphilic γ-PGA-based micelles(AM) carrying PTX(PDA/AM/P) exerted near-infraredresponsive photothermal effects. Near-infrared irradiation of cancer cells treated with PDA/AM/P nanoparticles produced a greater anticancer effect than that observed in other treatment groups, indicating a synergistic effect. Intravenous administration of PDA/AM/P completely ablated tumors and prevented their recurrence. Notably, the in vivo safety profile of PDA/AM/P nanoparticles allowed PTX to be delivered at a 3.6-fold higher dose than was possible with PTX solubilized in surfactant, and circumvented the side effects of the surfactant. These results support the multifunctional potential of PDA/AM for the delivery of various hydrophobic drugs and imaging dyes for safe translation of nanomaterials into the clinic. | Dongyoon Kim Quoc-Viet Le Young Bong Kim Yu-Kyoung Oh | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 2 |
| 4 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 5 | Infection complications in febrile chimeric antigen receptor(CAR)-T recipients during the peri-CAR-T cell treatment period examined using metagenomic next-generation sequencing(mNGS)显示文摘Dear Editor,Chimeric antigen receptor-engineered(CAR)-T cell therapy has achieved unprecedented efficacy on refractory/relapsed B-cell malignancies[1].Yet,CAR-T recipients are highly susceptible to infection due to the immunodeficiency caused by B-cell aplasia and the pretreatment with chemotherapy.However,due to the systematic use of empirical broad-spectrum antibiotics and immunosuppressors to control cytokine release syndrome(CRS)reaction,microbiological diagnosis of infection has remained challenging in CAR-T recipients. | Jiali Nie Li Yang Liang Huang Lili Gao Ken He Young Jehane Michael Le Grange Xingcheng Yang Jia Wei Min Xiao Jianfeng Zhou | 2022 | Cancer Communications2022，42，5： | 2 |
| 6 | In vivo efficacy of phage therapy for Mycobacterium avium infection as delivered by a nonvirulent mycobacterium 显示文摘 | Danelishvili L Young LS Bermudez LE | 2006 | Microb Drug Resist2006，12，1： | 1 |
| 7 | Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure显示文摘 | William T. Abraham James B. Young Angel R. León Stuart Adler Alan J. Bank Shelley A. Hall Randy Lieberman L Bing Liem John B. O’Connell John S. Schroeder Kevin R. Wheelan | 2004 | Circulation2004，，18： | 1 |
| 8 | The mRNA bind- ing proteins HuR and tristetraprolin regulate cyclooxygenase 2 ex- pression during colon carcinogenesis 显示文摘 | Young LE Sanduja S Bemis-Standoli K | 2009 | Gastroenterology2009，156，5： | 1 |
| 9 | Surrogate markers of health after titanium dental implant placement显示文摘 | Young C W Lee J S Le H | 2004 | J Oral Maxillofac Surg2004，62，11： | 1 |
| 10 | Fermentation of starch and protein in the colon: implications for genomic instability显示文摘 | LE LEU R K YOUNG G P | 2007 | Cancer Biol Ther2007，6，： | 1 |
| 11 | Efficient microwave-assisted synthesis of 1-(1 H -indol-1-yl)-2-phenyl-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols as antifungal agents显示文摘 | Nicolas Lebouvier Francis Giraud Typhanie Corbin Young Min Na Guillaume Le Baut Pascal Marchand Marc Le Borgne | 2006 | Tetrahedron Letters2006，，36： | 1 |
| 12 | Improvedsurvival of diabetic foot ulcer patients 1995-2008: possi-ble impact of aggressive cardiovascular risk management显示文摘 | Young MJ McCardle JE Randall LE | 2008 | Diabetes Care2008，31，11： | 1 |
| 13 | Production of TNF-alpha,IL-6 and TGF-beta,and expression of receptors for TNF-alpha and IL-6,during murine Mycobacterium avium infection显示文摘 | Champsi J Young LS Bermudez LE | | 0，，04： | 1 |
| 14 | RHS2,A POU domain-containing gene,and its expression in developing and adult rat显示文摘 | Le Moine C Young WS 3rd | 1992 | Proc Natl Acad Sci USA1992，89，8： | 1 |
| 15 | Mutations in the Gene Encoding Filamin A as a Cause for Familial Cardiac Valvular Dystrophy显示文摘 | Florence Kyndt Jean-Pierre Gueffet Vincent Probst Philippe Jaafar Antoine Legendre Fran?oise Le Bouffant Claire Toquet Estelle Roy Lesley McGregor Sally Ann Lynch Ruth Newbury-Ecob Vinh Tran Ian Young Jean-Noel Trochu Hervé Le Marec Jean-Jacques Schott | 2007 | Circulation2007，，1： | 1 |
| 16 | Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture显示文摘 | Young LE Fernandes K McEvoy TG | 2001 | Nat Genet2001，27，： | 1 |
| 17 | Large offspring syndrome in cattle and sheep显示文摘 | Young LE Sinclair KD Wilmut I | 1998 | Rev Reprod1998，3，： | 1 |
| 18 | RHS2,A POU domain-containing gene,and its expression in developing and adult rat显示文摘 | Le Moine C Young WS 3rd | 1992 | Proc Natl Acad Sci USA1992，89，8： | 1 |
| 19 | Improved survival of diabetic foot ulcer patients 1995-2008:possible impact of aggressive cardiovascular risk management显示文摘 | Young M J McCardle JE Randall LE | | 0，，11： | 1 |
| 20 | Faster generation of hiPSCs by coupling high-titer lentivirus and column-based positive selection显示文摘 | Dick E Matsa E Young LE | | 0，，06： | 1 |
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